Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Alexandre P. Meli"'
Autor:
Sharada Swaminathan, Linh Thuy Mai, Alexandre P. Meli, Liseth Carmona-Pérez, Tania Charpentier, Alain Lamarre, Irah L. King, Simona Stäger
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113879- (2024)
Summary: Maintenance of CD4 T cells during chronic infections is vital for limiting pathogen burden and disease recrudescence. Although inhibitory receptor expression by CD4 T cells is commonly associated with immune suppression and exhaustion, such
Externí odkaz:
https://doaj.org/article/2a1bfd25ac784d0a8331dd25d3590fd0
Autor:
Ludivine C. Litzler, Astrid Zahn, Alexandre P. Meli, Steven Hébert, Anne-Marie Patenaude, Stephen P. Methot, Adrien Sprumont, Thérence Bois, Daisuke Kitamura, Santiago Costantino, Irah L. King, Claudia L. Kleinman, Stéphane Richard, Javier M. Di Noia
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Protective antibody responses depend critically on proper B cell development and differentiation at multiple stages. Here the authors show that a protein arginine methyltransferase, Prmt5 uses multiples pathways to prevent death of immature B cells,
Externí odkaz:
https://doaj.org/article/33da862d42ce48bf82823c6742c63b37
Publikováno v:
Annual Review of Immunology. 39:791-817
Programmed cell death (PCD) is a requisite feature of development and homeostasis but can also be indicative of infections, injuries, and pathologies. In concordance with these heterogeneous contexts, an array of disparate effector responses occur do
Publikováno v:
Annual review of immunology. 39
Programmed cell death (PCD) is a requisite feature of development and homeostasis but can also be indicative of infections, injuries, and pathologies. In concordance with these heterogeneous contexts, an array of disparate effector responses occur do
Autor:
Yong Kong, Malay Kumar Basu, Sourav Ghosh, Carla V. Rothlin, Yaqiu Wang, Alexandre P. Meli, Dimitri A. de Kouchkovsky
Naïve T cells are generally considered to be a homogeneous population, but for their unique T cell receptors (TCRs). Naïve T cells are activated within a specific cytokine milieu upon interaction with antigen-presenting cells through cognate TCR::M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cc88646e7192864799437912b8c16d5
https://doi.org/10.1101/2020.08.31.275842
https://doi.org/10.1101/2020.08.31.275842
Autor:
Alexei V. Tumanov, Jörg H. Fritz, Katja Mohrs, Fanny Tzelepis, Alexandre P. Meli, Elizabeth A. Leadbetter, Markus Mohrs, Paula A. Lanthier, J. Downey, Irah L. King, Maziar Divangahi
Publikováno v:
Mucosal immunology
Homeostasis is a fundamental principle of biological systems. A paradigm of immune homeostasis is the remarkably constant number of naive T and B lymphocytes in the body that continuously circulate through the secondary lymphoid organs to maximize im
Autor:
Hua Gu, Alexandre P. Meli, Xin Li, Liying Gong, Weili Sun, Irah L. King, Yong-Rui Zou, Danielle Karo-Atar
Publikováno v:
The Journal of Experimental Medicine
Antigen uptake and presentation by naive and germinal center (GC) B cells are different, with the former expressing even low-affinity BCRs efficiently capture and present sufficient antigen to T cells, whereas the latter do so more efficiently after
Autor:
Xin Li, Mariko Witalis, Joanne Leung, Sahar Bagherzadeh Yazdchi, Irah L. King, Hua Gu, Randy L. Johnson, Stephen L. Nutt, Vincent Panneton, Jinsam Chang, Joanna Li, Alexandre P. Meli, Woong-Kyung Suh, Dae-Sik Lim
The protein kinase Mst1 is a key component of the evolutionarily conserved Hippo pathway that regulates cell survival, proliferation, differentiation, and migration. In humans, Mst1 deficiency causes primary immunodeficiency. Patients with MST1-null
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43640ad5a3e2d3cff8a40d4839118519
https://europepmc.org/articles/PMC6310088/
https://europepmc.org/articles/PMC6310088/
Autor:
Michael Elliot, Mifong Tam, Ghislaine Fontes, Mary M. Stevenson, Alexandre P. Meli, Stuart G. Tangye, André Ballesteros-Tato, Scott A Leddon, Irah L. King, Danielle T. Avery, Deborah J. Fowell, James H. Miller
Publikováno v:
Immunity. 45:831-846
T follicular helper (Tfh) cells are a CD4+ T cell subset critical for long-lived humoral immunity. We hypothesized that integrins play a decisive role in Tfh cell biology. Here we show that Tfh cells expressed a highly active form of leukocyte functi
Autor:
Adrien Sprumont, Ludivine C. Litzler, Santiago Costantino, Therence Bois, Anne-Marie Patenaude, Claudia L. Kleinman, Alexandre P. Meli, Irah L. King, Javier M. Di Noia, Astrid Zahn, Daisuke Kitamura, Steven Hébert, Stephen P. Methot, Stéphane Richard
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Mechanisms regulating B cell development, activation, education in the germinal center (GC) and differentiation, underpin the humoral immune response. Protein arginine methyltransferase 5 (Prmt5), which catalyzes most symmetric dimethyl arginine prot