Zobrazeno 1 - 3
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pro vyhledávání: '"Alexandre P. Alloy"'
Autor:
C. Michel Zwaan, Andrea Califano, Soheil Meshinchi, Adolfo A. Ferrando, Monique L. den Boer, Jovana Pavisic, Tanja A. Gruber, Alexandre P. Alloy, Rhonda E. Ries, James R. Downing
Publikováno v:
Cancer Research. 81:1-1
Despite recent advances, overall survival for children with acute myeloid leukemia (AML) remains relatively low at 70 to 80%. Further refinement of risk stratification is paramount to guiding optimal therapy selection and improving outcomes. In this
Autor:
Olumide Kayode, Alexandra Hockla, Alexandre P. Alloy, Ruiying Wang, Evette S. Radisky, Alexei S. Soares
Publikováno v:
Journal of Biological Chemistry. 290:21523-21535
Human mesotrypsin is highly homologous to other mammalian trypsins, and yet it is functionally unique in possessing resistance to inhibition by canonical serine protease inhibitors and in cleaving these inhibitors as preferred substrates. Arg-193 and
Publikováno v:
Protein Science. 21:1103-1112
Mesotrypsin displays unusual resistance to inhibition by polypeptide trypsin inhibitors and cleaves some such inhibitors as substrates, despite a high degree of conservation with other mammalian trypsins. Substitution of Arg for the generally conserv