Výsledky vyhledávání - "Alexandre Novoa"

Akademický článek

DNA display of glycoconjugates to emulate oligomeric interactions of glycans

Autor: Alexandre Novoa, Nicolas Winssinger

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 11, Iss 1, Pp 707-719 (2015)

Glycans (carbohydrate portion of glycoproteins and glycolipids) frequently exert their function through oligomeric interactions involving multiple carbohydrate units. In efforts to recapitulate the diverse spatial arrangements of the carbohydrate uni

Externí odkaz: https://doaj.org/article/38e8060034dd4703b21863f31eb32d91

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Dynamic Cooperative Glycan Assembly Blocks the Binding of Bacterial Lectins to Epithelial Cells

Autor: Takuya Machida, Julie Claudinon, Thorsten Eierhoff, Shuangshuang Zheng, Winfried Römer, Emilie Gillon, Alexandre Novoa, Anne Imberty, Nicolas Winssinger

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2017, 56 (24), pp.6762-6766. ⟨10.1002/anie.201700813⟩
Angewandte Chemie: International Edition, Vol. 56, No 24 (2017) pp. 6762-6766

International audience; Pathogens frequently rely on lectins for adhesion and cellular entry into the host. Since these interactions typically result from multimeric binding of lectins to cell surface glycans, novel therapeutic strategies are being d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8fd9f2bd50c08c40d22e54b2fd0749
https://doi.org/10.1002/ange.201700813

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DNA display of glycoconjugates to emulate oligomeric interactions of glycans

Autor: Nicolas Winssinger, Alexandre Novoa

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 11, Iss 1, Pp 707-719 (2015)
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry, Vol. 11 (2015) pp. 707-719

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ee6dc7ae922105bcd754135134620c
https://doaj.org/article/38e8060034dd4703b21863f31eb32d91

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In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated Dmt1-DALDA Analogues

Autor: Patrycja Kleczkowska, Dirk Tourwé, Csaba Tömböly, Lipkowski Andrzej W, Steven Ballet, Carsten Uhd Nielsen, Anna Lesniak, Birger Brodin, Cecilia Betti, Nga N. Chung, Hans Christian Cederberg Helms, Peter W. Schiller, Alexandre Novoa

Publikováno v: ACS Medicinal Chemistry Letters. 5:352-357

In this study the μ opioid receptor (MOR) ligands DALDA (Tyr-d-Arg-Phe-Lys-NH2) and Dmt1-DALDA (Dmt-d-Arg-Phe-Lys-NH2, Dmt = 2',6'-dimethyltyrosine) were glycosylated at the N- or C-terminus. Subsequently, the modified peptides were subjected to in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca826047dd050f8e86be1bbb635ad440
https://doi.org/10.1021/ml4004765

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PNA-encoded synthesis (PES) of a 10 000-member hetero-glycoconjugate library and microarray analysis of diverse lectins

Autor: Nicolas Winssinger, Takuya Machida, Anne Imberty, Alexandre Novoa, Sofia Barluenga

Publikováno v: Chembiochem : a European journal of chemical biology
ChemBioChem, Vol. 15, No 14 (2014) pp. 2058-2065
ChemBioChem
ChemBioChem, Wiley-VCH Verlag, 2014, pp.2058-2065

Identification of selective and synthetically tractable ligands to glycan-binding proteins is important in glycoscience. Carbohydrate arrays have had a tremendous impact on profiling glycan-binding proteins and as analytical tools. We report a highly

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ChemInform Abstract: DNA Display of Glycoconjugates to Emulate Oligomeric Interactions of Glycans

Autor: Alexandre Novoa, Nicolas Winssinger

Publikováno v: ChemInform. 47

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30ef3eddf5a07dbb2dacf04b5b77770a
https://doi.org/10.1002/chin.201612279

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Variation of the Net Charge, Lipophilicity, and Side Chain Flexibility in Dmt1-DALDA: Effect on Opioid Activity and Biodistribution

Autor: Sofie Stalmans, Steven Ballet, Carole Lemieux, Dirk Tourwé, Nathalie Bracke, Mariana Spetea, Mark E. Cooper, Peter W. Schiller, Bart De Spiegeleer, Evelien Wynendaele, Sylvia Van Dorpe, Johannes Zuegg, Cecilia Betti, Alexandre Novoa, Nga N. Chung

Publikováno v: Journal of Medicinal Chemistry. 55:9549-9561

The influence of the side chain charges of the second and fourth amino acid residues in the peptidic mu opioid lead agonist Dmt-D-Arg-Phe-Lys-NH2. ([Dmt(1)-DALDA) was examined. Additionally, to increase the overall lipophilicity of [Dmt(1)]-DALDA and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f81ee53381e5e00aee9c3099f9d38e
https://doi.org/10.1021/jm3008079

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Efficient access to disubstituted exo-glycals. Application to the preparation of C-glycosyl compounds

Autor: Yves Chapleur, Nadia Pellegrini-Moïse, Sandrine Lamandé-Langle, Alexandre Novoa

Publikováno v: Tetrahedron Letters. 50:6484-6487

Efficient methods of preparation of disubstituted exo-glycals by palladium cross-coupling reaction on the readily available dibromo exo-glycal and methoxycarbonyl exo-glycal have been developed. Hydrogenation of these new monosubstituted and disubsti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12220d3c82cf470603eee1def31d522e
https://doi.org/10.1016/j.tetlet.2009.09.019

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