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pro vyhledávání: '"Alexandre N. Rcom-H'cheo-Gauthier"'
Autor:
Alexandre N. Rcom-H’cheo-Gauthier, Samantha L. Osborne, Adrian C.B. Meedneniya, Dean Louis Pountney
Publikováno v:
Frontiers in Neuroscience, Vol 10 (2016)
Aggregation of the pre-synaptic protein, α-synuclein (α-syn), is the key aetiological factor in Parkinson’s disease (PD) and other alpha-synucleinopathies, such as multiple system atrophy and Dementia with Lewy bodies. Various triggers for pathol
Externí odkaz:
https://doaj.org/article/351dd0240ea3480c9c5cbe71f340332a
Autor:
Fleur A. McLeary, Alexandre N. Rcom-H’cheo-Gauthier, Michael Goulding, Rowan A. W. Radford, Yuho Okita, Peter Faller, Roger S. Chung, Dean L. Pountney
Publikováno v:
Cells, Vol 8, Iss 2, p 179 (2019)
The formation of cytotoxic intracellular protein aggregates is a pathological signature of multiple neurodegenerative diseases. The principle aggregating protein in Parkinson’s disease (PD) and atypical Parkinson’s diseases is α-synuclein (α-sy
Externí odkaz:
https://doaj.org/article/dad6a48b4e864abcb81692917788df72
Autor:
Tien K. Khoo, Alexandre N. Rcom-H'cheo-Gauthier, Michael Goulding, Jessica Kinder, Dean Louis Pountney, Roger S. Chung, Fleur A. McLeary, George D. Mellick
Publikováno v:
Neurotoxicity Research. 33:229-238
Intracellular aggregates of α-synuclein are the pathological hallmark of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), being linked to neurotoxicity. Multiple triggers of α-synuclein aggregation have been implicated, including rai
Autor:
Peter Faller, Michael Goulding, Yuho Okita, Alexandre N. Rcom-H'cheo-Gauthier, Roger S. Chung, Dean Louis Pountney
Publikováno v:
Frontiers in Neuroscience
Metallothioneins (MTs) are proteins that function by metal exchange to regulate the bioavailability of metals, such as zinc and copper. Copper functions in the brain to regulate mitochondria, neurotransmitter production, and cell signaling. Inappropr
Publikováno v:
Journal of neurochemistry. 141(2)
Many neurodegenerative diseases are characterized by the formation of microscopically visible intracellular protein aggregates. α-Synuclein is the key aggregating protein in Parkinson's disease which is characterized by neuronal cytoplasmic Lewy bod
Autor:
Roger S. Chung, Dean Louis Pountney, Yuho Okita, Rowan A. W. Radford, Alexandre N. Rcom-H'cheo-Gauthier, Peter Faller, Fleur A. McLeary, Michael Goulding
Publikováno v:
Cells
Cells, Vol 8, Iss 2, p 179 (2019)
Cells, Vol 8, Iss 2, p 179 (2019)
The formation of cytotoxic intracellular protein aggregates is a pathological signature of multiple neurodegenerative diseases. The principle aggregating protein in Parkinson’s disease (PD) and atypical Parkinson’s diseases is α-synuclein (α-sy
Autor:
Dean Louis Pountney, Alexandre N. Rcom-H'cheo-Gauthier, Adrian Cuda Banda Meedeniya, Amelia Davis
Publikováno v:
Molecular and cellular neurosciences. 77
α-Synuclein (α-syn) aggregates (Lewy bodies) in Dementia with Lewy Bodies (DLB) may be associated with disturbed calcium homeostasis and oxidative stress. We investigated the interplay between α-syn aggregation, expression of the calbindin-D28k (C
Autor:
W-P Gai, Stuart Dean Sharry, Alexandre N. Rcom-H'cheo-Gauthier, M.B. Wong, Adrian Cuda Banda Meedeniya, Dean Louis Pountney, Jenna Weetman
Publikováno v:
Neuroscience letters. 544
Parkinson's disease (PD) is a neurodegenerative disease resulting from progressive loss of dopaminergic nigrostriatal neurons. α-Synuclein protein conformational changes, resulting in cytotoxic/aggregated proteins, have been linked to PD pathogenesi