Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Alexandre McKeon"'
Autor:
Sushil Kumar, Claudia Mickael, Rahul Kumar, Ram Raj Prasad, Nzali V. Campbell, Hui Zhang, Min Li, B. Alexandre McKeon, Thaddeus E. Allen, Brian B. Graham, Yen-Rei A. Yu, Kurt R. Stenmark
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionHypoxia is a common pathological driver contributing to various forms of pulmonary vascular diseases leading to pulmonary hypertension (PH). Pulmonary interstitial macrophages (IMs) play pivotal roles in immune and vascular dysfunction, l
Externí odkaz:
https://doaj.org/article/ff6beb390653433dbe01318df19ac657
Autor:
Min Li, Suzette Riddle, Sushil Kumar, Joanna Poczobutt, B. Alexandre McKeon, Maria G. Frid, Maureen Ostaff, Julie A. Reisz, Travis Nemkov, Mehdi A. Fini, Aya Laux, Cheng-Jun Hu, Karim C. El Kasmi, Angelo D’Alessandro, R. Dale Brown, Hui Zhang, Kurt R. Stenmark
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The recruitment and subsequent polarization of inflammatory monocytes/macrophages in the perivascular regions of pulmonary arteries is a key feature of pulmonary hypertension (PH). However, the mechanisms driving macrophage polarization within the ad
Externí odkaz:
https://doaj.org/article/d01f4ee601ff4f7385290e36923e48f6
Autor:
Rahul Kumar, Claudia Mickael, Biruk Kassa, Liya Gebreab, Jeffrey C. Robinson, Daniel E. Koyanagi, Linda Sanders, Lea Barthel, Christina Meadows, Daniel Fox, David Irwin, Min Li, B. Alexandre McKeon, Suzette Riddle, R. Dale Brown, Leslie E. Morgan, Christopher M. Evans, Daniel Hernandez-Saavedra, Angela Bandeira, James P. Maloney, Todd M. Bull, William J. Janssen, Kurt R. Stenmark, Rubin M. Tuder, Brian B. Graham
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Thrombospondin-1 (TSP-1) activates latent TGF-β in the extracellular matrix. Here the authors show that inappropriate activation of latent TGF-β in murine, bovine and human lung by monocyte-produced TSP-1 causes pulmonary hypertension, and that int
Externí odkaz:
https://doaj.org/article/12cae9f76300462c9772bdd1e67bd44a
Autor:
Hui Zhang, Evgenia Gerasimovskaya, Mary K. McCarthy, Nicholas A. May, Ram Raj Prasad, Suzette Riddle, B Alexandre McKeon, Sushil Kumar, Min Li, Cheng-Jun Hu, Maria G Frid, Thomas E. Morrison, Kurt R Stenmark
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6eab7a321570e36edc4f43bbf10771bc
https://doi.org/10.1165/rcmb.2022-0373oc
https://doi.org/10.1165/rcmb.2022-0373oc
Autor:
Christopher J. Rhodes, Min Li, Aneta Gandjeva, B. Alexandre McKeon, Rui-Sheng Wang, Joshua M. Thurman, Jane A. Leopold, Hui Zhang, Rubin M. Tuder, V. Michael Holers, Sushil Kumar, Jennifer Laskowsky, Timothy M. Sullivan, Mehdi A. Fini, Samantha Hu, Bradley A. Maron, Pavandeep Ghataorhe, Maria G. Frid, Martin R. Wilkins, Kurt R. Stenmark
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
Rationale: Pulmonary hypertension (PH) is a life-threatening cardiopulmonary disorder in which inflammation and immunity have emerged as critical early pathogenic elements. Although proinflammatory processes in PH and pulmonary arterial hypertension
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae262e1e465000c232d4aacd14e460c6
http://europepmc.org/articles/PMC6961733
http://europepmc.org/articles/PMC6961733
Autor:
Maria G. Frid, Kurt R. Stenmark, Aya Laux, Karim C. El Kasmi, Sushil Kumar, Suzette R. Riddle, Joanna M. Poczobutt, Julie A. Reisz, B. Alexandre McKeon, R. Dale Brown, Maureen J. Ostaff, Min Li, Mehdi A. Fini, Angelo D'Alessandro, Travis Nemkov, Hui Zhang, Cheng-Jun Hu
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
The recruitment and subsequent polarization of inflammatory monocytes/macrophages in the perivascular regions of pulmonary arteries is a key feature of pulmonary hypertension (PH). However, the mechanisms driving macrophage polarization within the ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::966286f45b365e8bfccc582a2d524c9c
https://pubmed.ncbi.nlm.nih.gov/33868271
https://pubmed.ncbi.nlm.nih.gov/33868271
Autor:
Sushil Kumar, Amanda Flockton, Angela Caánovas, Karim C. El Kasmi, Soni Savai Pullamsetti, Natalie J. Serkova, Maria G. Frid, Qinghong Zhang, B. Alexandre McKeon, Juan F. Medrano, Lydie Plecitá-Hlavatá, Mehdi A. Fini, Hongbing Liu, Dijana Iloska, Radu Moldovan, Suzette R. Riddle, Kurt R. Stenmark, Kirk C. Hansen, Min Li, Angelo D'Alessandro, Hui Zhang, Petr Ježek, Hong Li, Milton G Thomas
Publikováno v:
Circulation, vol 134, iss 15
Background: Changes in metabolism have been suggested to contribute to the aberrant phenotype of vascular wall cells, including fibroblasts, in pulmonary hypertension (PH). Here, we test the hypothesis that metabolic reprogramming to aerobic glycolys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb75822ed5c242ea1bdbbc02c3b1b8f
https://doi.org/10.1161/circulationaha.116.023171
https://doi.org/10.1161/circulationaha.116.023171
Autor:
Daren Wang, Nicholas W. Morrell, Sushil Kumar, Kurt R. Stenmark, Cheng-Jun Hu, Min Li, Angelo D'Alessandro, Jan Tauber, Suzette R. Riddle, Karim C. El Kasmi, Hui Zhang, Maria G. Frid, Paola Caruso, B. Alexandre McKeon, Lydie Plecitá-Hlavatá, Amanda Flockton, Petr Ježek, Julie A. Reisz
Background: An emerging metabolic theory of pulmonary hypertension (PH) suggests that cellular and mitochondrial metabolic dysfunction underlies the pathology of this disease. We and others have previously demonstrated the existence of hyperprolifera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0899fd963b9c1d4ccdb3c5478e9eaaa8
Autor:
Daniel Hernandez-Saavedra, Rubin M. Tuder, R. Dale Brown, James P. Maloney, Angela Bandeira, Suzette R. Riddle, B. Alexandre McKeon, Lea Barthel, Christina Meadows, Jeffrey C. Robinson, Brian B. Graham, Rajesh Kumar, Todd M. Bull, Liya Gebreab, Linda Sanders, Kurt R. Stenmark, Claudia Mickael, Daniel L. Fox, Leslie E. Morgan, Daniel E. Koyanagi, David Irwin, Biruk Kassa, Christopher M. Evans, William J. Janssen, Min Li
Publikováno v:
Nature communications, vol 8, iss 1
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications
Pulmonary arterial hypertension (PAH) is an obstructive disease of the precapillary pulmonary arteries. Schistosomiasis-associated PAH shares altered vascular TGF-β signalling with idiopathic, heritable and autoimmune-associated etiologies; moreover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768240ee00e1b51d2a84960a799e215b
https://escholarship.org/uc/item/1108505b
https://escholarship.org/uc/item/1108505b
Autor:
Hui Zhang, Kurt R. Stenmark, Min Li, Carmen C. Sucharov, Michael E. Yeager, Werner Seeger, Maria G. Frid, Sivareddy Velegala, Daren Wang, Nicholas W. Morrell, Mehdi A. Fini, Soni Savai Pullamsetti, Timothy A. McKinsey, B. Alexandre McKeon, Amanda Flockton
Publikováno v:
Circulation Research. 114:67-78
Rationale : Pulmonary hypertensive remodeling is characterized by excessive proliferation, migration, and proinflammatory activation of adventitial fibroblasts. In culture, fibroblasts maintain a similar activated phenotype. The mechanisms responsibl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b6a845af68827acf81113847d1a10d
https://doi.org/10.1161/circresaha.114.301633
https://doi.org/10.1161/circresaha.114.301633