Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Alexandre Mayran"'
Autor:
Ines Desanlis, Yacine Kherdjemil, Alexandre Mayran, Yasser Bouklouch, Claudia Gentile, Rushikesh Sheth, Rolf Zeller, Jacques Drouin, Marie Kmita
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Pioneer factors direct cell fate through switching inaccessible chromatin to an accessible state at specific target enhancers. Here the authors show that HOX13 transcription factors have a pioneer activity which is required for the proper implementat
Externí odkaz:
https://doaj.org/article/f7f1aa4b6fd944ee94c69c85f704d178
Autor:
Konstantin Khetchoumian, Aurélio Balsalobre, Alexandre Mayran, Helen Christian, Valérie Chénard, Julie St-Pierre, Jacques Drouin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Pituitary POMC secreting cells achieve high hormone expression levels after birth but the mechanism for this regulation is unclear. Here, the authors show that this process is driven cell autonomously by the differentiation factor Tpit that activates
Externí odkaz:
https://doaj.org/article/2ded1151fab64ba68a4d5db6a8ce4a72
Autor:
Alexandre Mayran, Kevin Sochodolsky, Konstantin Khetchoumian, Juliette Harris, Yves Gauthier, Amandine Bemmo, Aurelio Balsalobre, Jacques Drouin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Pioneer transcription factor Pax7 specifies melanotrope cells, which then allows for the binding of Tpit transcription factor. Here, authors find that while binding of heterochromatin targeting by Pax7 is independent of Tpit, Pax7-dependent chromatin
Externí odkaz:
https://doaj.org/article/3b2a61a2cc2044b9be570ebc3124d40d
Publikováno v:
DNA and Cell Biology
The current pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected most of the world in a profound way. As an indirect consequence, the general public has been put into direct contact with the research process, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fce980af11beb424f8599e40202d7b6
https://doi.org/10.1089/dna.2021.0514
https://doi.org/10.1089/dna.2021.0514
The Polycomb Repressive Complexes (PRC) are key players in the regulation of tissue-specific gene expression through their ability to epigenetically silence developmental genes. They are subdivided into two multicomponent complexes, PRC1 and PRC2, fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb9f269f4b40ba6a223de349e14646f7
https://doi.org/10.1101/2021.10.28.466236
https://doi.org/10.1101/2021.10.28.466236
Autor:
Helen C. Christian, Alexandre Mayran, Konstantin Khetchoumian, Jacques Drouin, Aurelio Balsalobre, Julie St-Pierre, Valérie Chénard
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
Translation is a basic cellular process and its capacity is adapted to cell function. In particular, secretory cells achieve high protein synthesis levels without triggering the protein stress response. It is unknown how and when translation capacity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25237f9ae564c351ac182e8d3df7d077
https://doaj.org/article/2ded1151fab64ba68a4d5db6a8ce4a72
https://doaj.org/article/2ded1151fab64ba68a4d5db6a8ce4a72
Autor:
Alexandre Mayran, Jacques Drouin, James G. Omichinski, Arthur Gouhier, Aurelio Balsalobre, Audrey Pelletier
Publikováno v:
Nucleic Acids Research
The pioneer transcription factor Pax7 contains two DNA binding domains (DBD), a paired and a homeo domain. Previous work on Pax7 and the related Pax3 had shown that each DBD can bind a cognate DNA sequence, thus defining two targets of binding and po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac79fa7bde2b356806831dd3866df3bc
https://doi.org/10.1101/2020.10.09.332015
https://doi.org/10.1101/2020.10.09.332015
The Polycomb group (PcG) proteins are key players in the regulation of tissue-specific gene expression through their known ability to epigenetically silence developmental genes. The PcG proteins form two multicomponent complexes, Polycomb Repressive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78a0625bdbce1c68df30e07b984f5d22
https://doi.org/10.1101/2020.09.21.306688
https://doi.org/10.1101/2020.09.21.306688
Autor:
Marie Kmita, Claudia Gentile, Jacques Drouin, Yacine Kherdjemil, Ines Desanlis, Rolf Zeller, Alexandre Mayran, Yasser Bouklouch, Rushikesh Sheth
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Hox genes encode transcription factors (TFs) that establish morphological diversity in the developing embryo. The similar DNA-binding motifs of the various HOX TFs contrast with the wide-range of HOX-dependent genetic programs. The influence of the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6260b5150d970f048da4634bdf7b1ffd
http://europepmc.org/articles/PMC7237422
http://europepmc.org/articles/PMC7237422
Autor:
Huashan Peng, Carl Ernst, Blandine Ponroy Bally, Jacques Drouin, Emma V. Jones, Selin Jessa, Alexandre Mayran, Keith K. Murai, W. Todd Farmer, Arnold Hayer, J. Benjamin Kacerovsky, Julie L. Lefebvre
Publikováno v:
Hum Mol Genet
Down syndrome (DS), caused by the triplication of human chromosome 21, leads to significant alterations in brain development and is a major genetic cause of intellectual disability. While much is known about changes to neurons in DS, the effects of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a00e1878a8aa86986c0cd505c8c012
https://europepmc.org/articles/PMC7104679/
https://europepmc.org/articles/PMC7104679/