Reversible Photocontrol of Dopaminergic Transmission in Wild-Type Animals

Autor: Carlo Matera, Pablo Calvé, Verònica Casadó-Anguera, Rosalba Sortino, Alexandre M. J. Gomila, Estefanía Moreno, Thomas Gener, Cristina Delgado-Sallent, Pau Nebot, Davide Costazza, Sara Conde-Berriozabal, Mercè Masana, Jordi Hernando, Vicent Casadó, M. Victoria Puig, Pau Gorostiza

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 17, p 10114 (2022)

Understanding the dopaminergic system is a priority in neurobiology and neuropharmacology. Dopamine receptors are involved in the modulation of fundamental physiological functions, and dysregulation of dopaminergic transmission is associated with maj

Externí odkaz: https://doaj.org/article/e2bdf135b54a428ab7ab2892ef4d150b

Subunit-specific photocontrol of glycine receptors by azobenzene-nitrazepam photoswitcher

Autor: Piotr Bregestovski, Daniel Wutz, Mercedes Alfonso-Prieto, Alexandre M. J. Gomila, Elena Petukhova, Daria Ponomareva, Alba Nin-Hill, Elvira Mukhametova, Galyna Maleeva, Burkhard König, Pau Gorostiza, Karin Rustler

Publikováno v: Juelich Shared Electronic Resources
Recolector de Ciencia Abierta, RECOLECTA
PubMed Central
Diposit Digital de la Universitat de Barcelona
ZENODO
UnpayWall
ORCID
Microsoft Academic Graph
eNeuro
eNeuro 8(1), ENEURO.0294-20.2020 (2021). doi:10.1523/ENEURO.0294-20.2020
Dipòsit Digital de la UB
Universidad de Barcelona

Visual Abstract
Photopharmacology is a unique approach that through a combination of photochemistry methods and advanced life science techniques allows the study and control of specific biological processes, ranging from intracellular pathways t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85157fce2e1f37520dd1f809189e5c0b
http://europepmc.org/articles/PMC7877471

Optical Control of GABA

Autor: Karin, Rustler, Galyna, Maleeva, Alexandre M J, Gomila, Pau, Gorostiza, Piotr, Bregestovski, Burkhard, König

Publikováno v: Chemistry (Weinheim an Der Bergstrasse, Germany)

Optogenetic and photopharmacological tools to manipulate neuronal inhibition have limited efficacy and reversibility. We report the design, synthesis, and biological evaluation of Fulgazepam, a fulgimide derivative of benzodiazepine that behaves as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cd1c05a23ac3bcb5a0d37725a40453ab
https://pubmed.ncbi.nlm.nih.gov/32307732

Photocontrol of endogenous glycine receptors in vivo

Autor: Elvira Mukhametova, Alexandre M. J. Gomila, Karin Rustler, Piotr Bregestovski, Pau Gorostiza, Frank Peiretti, Miquel Bosch, Carme Rovira, Burkhard König, Alba Nin-Hill, Galyna Maleeva, Antoni Bautista-Barrufet, Xavier Rovira, Daniel Wutz, Marat A. Mukhamedyarov, Mercedes Alfonso-Prieto

Glycine receptors (GlyRs) are indispensable to maintain excitatory/inhibitory balance in neuronal circuits controlling reflex and rhythmic motor behaviors. Here we have developed Glyght, the first GlyR ligand controlled with light. It is selective ov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24cd45c9903cfa5a1aa7547cd47b9398

Control of Cardiac Function in vivo with a Light-Regulated Drug

Autor: Carlo Matera, Alexandre M. J. Gomila, Ulrike Holzgrabe, Enrique Claro, Eduard Guasch, Fabio Riefolo, Pau Gorostiza, Michael Decker, Aida Garrido-Charles, Montserrat Batlle, Roser Masgrau, Luca Agnetta

Remote control of physiological functions with light offers the promise of unveiling their complex spatiotemporal dynamics in vivo, and enabling highly focalized therapeutic interventions with reduced systemic toxicity. Optogenetic methods have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5187e88e61803e404ffc09684150966
https://doi.org/10.26434/chemrxiv.7472174.v1