Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Alexandre L N Silva"'
1
Akademický článek
Guanylate-binding protein 5 licenses caspase-11 for Gasdermin-D mediated host resistance to Brucella abortus infection.
Autor: Daiane M Cerqueira, Marco Túlio R Gomes, Alexandre L N Silva, Marcella Rungue, Natan R G Assis, Erika S Guimarães, Suellen B Morais, Petr Broz, Dario S Zamboni, Sergio C Oliveira
Publikováno v: PLoS Pathogens, Vol 14, Iss 12, p e1007519 (2018)
Innate immune response against Brucella abortus involves activation of Toll-like receptors (TLRs) and NOD-like receptors (NLRs). Among the NLRs involved in the recognition of B. abortus are NLRP3 and AIM2. Here, we demonstrate that B. abortus trigger
Externí odkaz: https://doaj.org/article/a8310491074f45678e18d0d2ff7ae6b3
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2
Akademický článek
A parent-of-origin effect determines the susceptibility of a non-informative F1 population to Trypanosoma cruzi infection in vivo.
Autor: Grace K Silva, Larissa D Cunha, Catarina V Horta, Alexandre L N Silva, Fredy R S Gutierrez, João S Silva, Dario S Zamboni
Publikováno v: PLoS ONE, Vol 8, Iss 2, p e56347 (2013)
The development of Chagas disease is determined by a complex interaction between the genetic traits of both the protozoan parasite, T. cruzi, and the infected host. This process is regulated by multiple genes that control different aspects of the hos
Externí odkaz: https://doaj.org/article/98d52c80967f410e8bfba9469cad2f63
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3
The role of annexin A1 in the modulation of the NLRP3 inflammasome
Autor: Renan V. H. de Carvalho, Toniana G. Carvalho, Izabela Galvão, Lirlândia P. Sousa, Juliana P. Vago, Fabiola M. Ribeiro, Maísa Mota Antunes, Gustavo B. Menezes, Alexandre L. N. Silva, Dario S. Zamboni, Mauro M. Teixeira
Publikováno v: Immunology
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Annexins are well‐known Ca(2+ )phospholipid‐binding proteins, which have a wide variety of cellular functions. The role of annexin A1 (AnxA1) in the innate immune system has focused mainly on the anti‐inflammatory and proresolving properties th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::587ac26718f24d6cea62b46fff6c50ce
https://europepmc.org/articles/PMC7160667/
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4
AIM2 Engages Active but Unprocessed Caspase-1 to Induce Noncanonical Activation of the NLRP3 Inflammasome
Autor: Leonardo L. Santos, Richard A. Flavell, Larissa D. Cunha, Gustavo Fernando da Silva Quirino, Dario S. Zamboni, Danielle P. A. Mascarenhas, Juliana M. Ribeiro, Alexandre L. N. Silva
Publikováno v: Cell Reports, Vol 20, Iss 4, Pp 794-805 (2017)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Summary Inflammasomes are multimeric protein complexes that initiate inflammatory cascades. Their activation is a hallmark of many infectious or inflammatory diseases. Their composition and activity are specified by proinflammatory stimuli. For examp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e331321794ab179f9c597961da82fb3
http://www.sciencedirect.com/science/article/pii/S2211124717309348
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6
Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition
Autor: Marisa Dilucca, Tamara S Rodrigues, Renan V. H. de Carvalho, Djalma S. Lima-Junior, Angela K. Cruz, Dario S. Zamboni, Ricardo de Godoi Mattos Ferreira, Fausto Almeida, Alexandre L. N. Silva, Fabiani Gai Frantz, Catarina V. Horta, Marcos Michel de Souza, Patrick F. da Silva, Lucas B. Lorenzon, Lilian Motta Cantanhêde, Marcus Vinicius Gomes da Silva
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Leishmania RNA virus (LRV) is an important virulence factor associated with the development of mucocutaneous Leishmaniasis, a severe form of the disease. LRV-mediated disease exacerbation relies on TLR3 activation, but downstream mechanisms remain la
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::766b0d7ae6f6b589a2908e669ce093f3
https://doi.org/10.1038/s41467-019-13356-2
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7
Macrophage priming is dispensable for NLRP3 inflammasome activation and restriction of Leishmania amazonensis replication
Autor: Dario S. Zamboni, Renan V. H. de Carvalho, Keyla Santos Guedes de Sá, Warrison A. Andrade, Leonardo L. Santos, Alexandre L. N. Silva
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
The NLRP3 inflammasome is activated in response to multiple stimuli and triggers activation of caspase-1 (CASP1), IL-1β production, and inflammation. NLRP3 activation requires two signals. The first leads to transcriptional regulation of specific ge
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::826fbd21c66e122500e8c87219be3f83
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8
Guanylate-binding protein 5 licenses caspase-11 for Gasdermin-D mediated host resistance to Brucella abortus infection
Autor: Suellen B. Morais, Sergio C. Oliveira, Alexandre L. N. Silva, Dario S. Zamboni, Erika S. Guimarães, Daiane M. Cerqueira, Marcella Rungue, Marco Túlio R. Gomes, Natan R. G. Assis, Petr Broz
Publikováno v: PLoS pathogens, vol. 14, no. 12, pp. e1007519
PLoS Pathogens
PLoS Pathogens, Vol 14, Iss 12, p e1007519 (2018)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Innate immune response against Brucella abortus involves activation of Toll-like receptors (TLRs) and NOD-like receptors (NLRs). Among the NLRs involved in the recognition of B. abortus are NLRP3 and AIM2. Here, we demonstrate that B. abortus trigger
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0197a0ac44e4e23ce944e84e28c6680e
https://serval.unil.ch/resource/serval:BIB_657DFCFBDA80.P001/REF.pdf
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9
Caspase-1 but Not Caspase-11 Is Required for NLRC4-Mediated Pyroptosis and Restriction of Infection by Flagellated Legionella Species in Mouse Macrophages and In Vivo
Autor: Larissa D. Cunha, Daiane M. Cerqueira, Alexandre L. N. Silva, Dario S. Zamboni, Marcelo S. F. Pereira
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Gram-negative bacteria from the Legionella genus are intracellular pathogens that cause a severe form of pneumonia called Legionnaires’ disease. The bacteria replicate intracellularly in macrophages, and the restriction of bacterial replication by
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a3d3be56d408073290cb233ac509c6b
https://pubmed.ncbi.nlm.nih.gov/26232428
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10
Inflammasome-derived IL-1'beta' production induces nitric oxide-mediated resistance to Leishmania
Autor: Dario S. Zamboni, Fredy R. S. Gutierrez, João Santana da Silva, Maria Bellio, Marcelo T. Bozza, Djalma S. Lima-Junior, Vanessa Carregaro, Richard A. Flavell, Larissa D. Cunha, Alexandre L. N. Silva, Tiago W. P. Mineo, Diego L. Costa, Karina R. Bortoluci
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Parasites of the Leishmania genus are the causative agents of leishmaniasis in humans, a disease that affects more than 12 million people worldwide. These parasites replicate intracellularly in macrophages, and the primary mechanisms underlying host
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b035468ed988d0f150e067ae64ec67c
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