Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Alexandre K. Rouquette-Jazdanian"'
Autor:
Alexandre K Rouquette-Jazdanian, Robert L Kortum, Wenmei Li, Robert K Merrill, Phan H Nguyen, Lawrence E Samelson, Connie L Sommers
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131823 (2015)
Linker for Activation of T cells (LAT) is an adapter protein that is essential for T cell function. Knock-in mice with a LAT mutation impairing calcium flux develop a fatal CD4+ lymphoproliferative disease. miR-155 is a microRNA that is correlated wi
Externí odkaz:
https://doaj.org/article/03cf505e37834812bd4cc6d93e2df137
Autor:
Connie L Sommers, Alexandre K Rouquette-Jazdanian, Ana I Robles, Robert L Kortum, Robert K Merrill, Wenmei Li, Nandan Nath, Elizabeth Wohlfert, Katherine M Sixt, Yasmine Belkaid, Lawrence E Samelson
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66709 (2013)
Helper T cells from a mutant mouse model, LAT Y136F, hyper-proliferate and cause a severe lymphoproliferative disease that kills the mice by six months of age. LAT Y136F mice carry a tyrosine to phenylalanine mutation in the Linker for Activation of
Externí odkaz:
https://doaj.org/article/b7f3e2322d024f03b46f3a24eadde5b5
Publikováno v:
Trends in Immunology. 34:259-268
Extracellular signal-regulated kinase (ERK) activation is important for both thymocyte development and T cell function. Classically, signal transduction from the T cell antigen receptor (TCR) to ERK is thought to be regulated by signaling from Ras gu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09687f593ea05c52c0d1026091ad095d
https://doi.org/10.1016/j.it.2013.02.004
https://doi.org/10.1016/j.it.2013.02.004
Autor:
Michihiko Miyaji, Alexandre K. Rouquette-Jazdanian, Evan Markegard, John M. Pinski, Connie L. Sommers, Amelia K. Wesselink, Lawrence E. Samelson, Clayton P. Alexander, Jeroen P. Roose, Nandan N. Nath, Wenmei Li, Peter M. Blumberg, Robert L. Kortum, Robert K. Merrill, Noemi Kedei
Publikováno v:
The Journal of Immunology. 190:147-158
Mice expressing a germline mutation in the phospholipase C-γ1–binding site of linker for activation of T cells (LAT) show progressive lymphoproliferation and ultimately die at 4–6 mo age. The hyperactivated T cells in these mice show defective T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3235114a40d040b26ce738e722887fa
https://doi.org/10.4049/jimmunol.1201458
https://doi.org/10.4049/jimmunol.1201458
Autor:
Robert L. Kortum, Lawrence E. Samelson, Deborah K. Morrison, Connie L. Sommers, Alexandre K. Rouquette-Jazdanian
Publikováno v:
Molecular Cell. 48:298-312
In T cells the adapter Bam32 is coupled to Erk activation downstream of the TCR by an unknown mechanism. We characterized in Jurkat cells and primary T lymphocytes, a pathway dependent on Bam32-PLC-γ1-Pak1 complexes, in which Pak1 kinase activates R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1bd257fc1d0e80e115aac960e0544e
https://doi.org/10.1016/j.molcel.2012.08.011
https://doi.org/10.1016/j.molcel.2012.08.011
Autor:
Robert L. Kortum, Wenmei Li, Phan H. Nguyen, Alexandre K. Rouquette-Jazdanian, Connie L. Sommers, Robert K. Merrill, Lawrence E. Samelson
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 6, p e0131823 (2015)
PLoS ONE, Vol 10, Iss 6, p e0131823 (2015)
Linker for Activation of T cells (LAT) is an adapter protein that is essential for T cell function. Knock-in mice with a LAT mutation impairing calcium flux develop a fatal CD4+ lymphoproliferative disease. miR-155 is a microRNA that is correlated wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b423a797b0a36af7147e7d32a9a667
https://pubmed.ncbi.nlm.nih.gov/26121028
https://pubmed.ncbi.nlm.nih.gov/26121028
Autor:
Laurence Lamy, Patricia Lagadec, Claude Aussel, Claudette Pelassy, Alexandre K. Rouquette-Jazdanian, Arnaud Foussat, Jean-Philippe Breittmayer
Publikováno v:
The Journal of Immunology. 175:5637-5648
The inhibition of human CD4+ T lymphocyte activation and proliferation by cholera toxin B-subunit (CTB) is a well-established phenomenon; nevertheless, the exact mechanism remained unclear. In the present study, we propose an explanation for the rCTB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee40ec6e72e51b47ca5805de0b65fc9e
https://doi.org/10.4049/jimmunol.175.9.5637
https://doi.org/10.4049/jimmunol.175.9.5637
Autor:
Alexandre K. ROUQUETTE-JAZDANIAN, Claudette PELASSY, Jean-Philippe BREITTMAYER, Jean-Louis COUSIN, Claude AUSSEL
Publikováno v:
Biochemical Journal. 363:645-655
Cell membranes contain sphingolipids and cholesterol, which cluster together in distinct domains called rafts. The outer-membrane leaflet of these peculiar membrane domains contains glycosylphosphatidylinositol-anchored proteins, while the inner leaf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a084c3c8814cdf757abcca10435b390e
https://doi.org/10.1042/bj3630645
https://doi.org/10.1042/bj3630645
Autor:
Ana I. Robles, Robert L. Kortum, Elizabeth A. Wohlfert, Connie L. Sommers, Nandan N. Nath, Robert K. Merrill, Wenmei Li, Lawrence E. Samelson, Yasmine Belkaid, Alexandre K. Rouquette-Jazdanian, Katherine Sixt
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 6, p e66709 (2013)
PLoS ONE, Vol 8, Iss 6, p e66709 (2013)
Helper T cells from a mutant mouse model, LAT Y136F, hyper-proliferate and cause a severe lymphoproliferative disease that kills the mice by six months of age. LAT Y136F mice carry a tyrosine to phenylalanine mutation in the Linker for Activation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e023454743c2a05afee99e835c2f25b8
http://europepmc.org/articles/PMC3692518
http://europepmc.org/articles/PMC3692518
Autor:
Monique Pourtein, Alain Bernard, Isabelle Alberti, Ghislaine Bernard, Claudette Pelassy, Alexandre K. Rouquette-Jazdanian, Claude Aussel
Publikováno v:
The FASEB Journal. 16:1946-1948
CD99, a unique integral membrane protein present on the surface of all human T cells, has previously been shown to regulate cell function and fate. In peripheral T cells, it triggers immediate activation of alpha4b1 integrin and cell arrest on inflam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c295748fbccce0bd134d47b7aad93fa8
https://doi.org/10.1096/fj.02-0049fje
https://doi.org/10.1096/fj.02-0049fje