Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Alexandre Janer"'
Autor:
Alexandre Janer, Julien Prudent, Vincent Paupe, Somayyeh Fahiminiya, Jacek Majewski, Nicolas Sgarioto, Christine Des Rosiers, Anik Forest, Zhen‐Yuan Lin, Anne‐Claude Gingras, Grant Mitchell, Heidi M McBride, Eric A Shoubridge
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 9, Pp 1019-1038 (2016)
Abstract Mitochondria form a dynamic network that responds to physiological signals and metabolic stresses by altering the balance between fusion and fission. Mitochondrial fusion is orchestrated by conserved GTPases MFN1/2 and OPA1, a process coordi
Externí odkaz:
https://doaj.org/article/22810f2315b34bb8997e0edcfcab588d
Autor:
Virginie Petel Légaré, Christian J. Rampal, Tyler J. N. Gurberg, Mari J. Aaltonen, Alexandre Janer, Lorne Zinman, Eric A. Shoubridge, Gary A. B. Armstrong
Publikováno v:
Developmental Neurobiology. 83:54-69
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52db07b39db37b6a634829f52ddbfdec
https://doi.org/10.1002/dneu.22909
https://doi.org/10.1002/dneu.22909
Autor:
Hui Zhong, Alexandre Janer, Oleh Khalimonchuk, Hana Antonicka, Eric A. Shoubridge, Antoni Barrientos
The human mitochondrial ribosome contains three [2Fe-2S] clusters whose assembly pathway, role, and implications for mitochondrial and metabolic diseases are unknown. Here, structure-function correlation studies show that the clusters play a structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07282801425e200aa3524a4a930fd31
https://doi.org/10.1101/2023.05.27.542581
https://doi.org/10.1101/2023.05.27.542581
Autor:
Alexandre Janer, Jordan L. Morris, Michiel Krols, Hana Antonicka, Mari J. Aaltonen, Zhen-Yuan Lin, Anne-Claude Gingras, Julien Prudent, Eric A. Shoubridge
SUMMARYMitochondria interact with the endoplasmic reticulum (ER) at structurally and functionally specialized membrane contact sites known as mitochondria-ER contact sites (MERCs). MERCs are crucial for a myriad of physiological functions including l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b55a63d56edb1c56765c922acd394791
https://doi.org/10.1101/2022.11.14.516495
https://doi.org/10.1101/2022.11.14.516495
Mutations in SLC25A46, coding for an outer mitochondrial membrane protein, underlie a wide spectrum of neurodegenerative diseases associated with alterations in mitochondrial morphology, but the precise role of the protein remains unknown. We establi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca0b51e9769e47ddfcf3df82f3e1277e
https://doi.org/10.1101/2022.09.16.508286
https://doi.org/10.1101/2022.09.16.508286
Autor:
Virginie Petel Légaré, Christian J. Rampal, Mari J. Aaltonen, Alexandre Janer, Lorne Zinman, Eric A. Shoubridge, Gary A.B. Armstrong
Mutations in CHCHD10 and CHCHD2, coding for two paralogous mitochondrial proteins, have been identified in amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTD), and Parkinson’s disease (PD). Here we investigated the biologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11dd79a414f75a3b76d7983333a19d6f
https://doi.org/10.1101/2022.05.02.488746
https://doi.org/10.1101/2022.05.02.488746
Publikováno v:
Life Science Alliance. 6:e202301914
Mutations inSLC25A46underlie a wide spectrum of neurodegenerative diseases associated with alterations in mitochondrial morphology. We established an SLC25A46 knock-out cell line in human fibroblasts and studied the pathogenicity of three variants (p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bec0f2fa580db3df2b6825563e7361a3
https://doi.org/10.26508/lsa.202301914
https://doi.org/10.26508/lsa.202301914
Autor:
François Ancien, Nicolas Sgarioto, Roxanne Larivière, Bernard Brais, Martje G Pauly, David-Alexandre Trégouët, Eric A. Shoubridge, Ganapathi Varma Saripella, Natalie Deininger, Marie Coutelier, Dimitri Gilis, Maxime Jacoupy, Léna Guillot-Noel, Khalid H El Hachimi, Alexandra Durr, Alexis Brice, Flore Renaud, Sabrina Sayah, G. Stevanin, Alexandre Janer, Perrine Charles, Marianne Rooman, Nicolas Auger, C. Helmchen, Isabelle Le Ber, Tobias B. Haack, Fabrizio Pucci, Rémi Valter, Astrid Nümann
Publikováno v:
Brain : a journal of neurology. 145(4)
With more than 40 causative genes identified so far, autosomal dominant cerebellar ataxias exhibit a remarkable genetic heterogeneity. Yet, half the patients are lacking a molecular diagnosis. In a large family with nine sampled affected members, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d45e8d52db810db9d681eb08300544
https://pubmed.ncbi.nlm.nih.gov/34788392
https://pubmed.ncbi.nlm.nih.gov/34788392
Autor:
Woranontee Weraarpachai, Anne-Claude Gingras, Eric A. Shoubridge, Alexandre Janer, Hana Antonicka, Zhen-Yuan Lin
Publikováno v:
Cell metabolism. 32(3)
SummaryWe used BioID, a proximity-dependent biotinylation assay, to interrogate 100 mitochondrial baits from all mitochondrial sub-compartments to create a high resolution human mitochondrial proximity interaction network. We identified 1465 proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbb79d6494f3ede5840174f791963839
https://pubmed.ncbi.nlm.nih.gov/32877691
https://pubmed.ncbi.nlm.nih.gov/32877691