International research to address the challenges of metastatic breast cancer: the AURORA Program (BIG 14-01)

Autor: Carmela Caballero, Alexandre Irrthum, Theodora Goulioti, David Cameron, Larry Norton, Martine Piccart

Publikováno v: npj Breast Cancer, Vol 9, Iss 1, Pp 1-5 (2023)

Despite recent advances in breast cancer research, we still know little about the mechanisms that lead to metastatic breast cancer (MBC). However, treatment options for patients have increased based on results of recent randomized clinical trials in

Externí odkaz: https://doaj.org/article/436a2c1778be464e9164bd48409f3557

Myelin-derived lipids modulate macrophage activity by liver X receptor activation.

Autor: Jeroen F J Bogie, Silke Timmermans, Vân Anh Huynh-Thu, Alexandre Irrthum, Hubert J M Smeets, Jan-Åke Gustafsson, Knut R Steffensen, Monique Mulder, Piet Stinissen, Niels Hellings, Jerome J A Hendriks

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e44998 (2012)

Multiple sclerosis is a chronic, inflammatory, demyelinating disease of the central nervous system in which macrophages and microglia play a central role. Foamy macrophages and microglia, containing degenerated myelin, are abundantly found in active

Externí odkaz: https://doaj.org/article/5aafb65e5a5b4dbea6049ae2cc79c7b5

Inferring regulatory networks from expression data using tree-based methods.

Autor: Vân Anh Huynh-Thu, Alexandre Irrthum, Louis Wehenkel, Pierre Geurts

Publikováno v: PLoS ONE, Vol 5, Iss 9, p e12776 (2010)

One of the pressing open problems of computational systems biology is the elucidation of the topology of genetic regulatory networks (GRNs) using high throughput genomic data, in particular microarray gene expression data. The Dialogue for Reverse En

Externí odkaz: https://doaj.org/article/13e2336da0c54cd497a5c68406a2a9ae

Supplementary methods, tables and figures. from Genomic and Transcriptomic Analyses of Breast Cancer Primaries and Matched Metastases in AURORA, the Breast International Group (BIG) Molecular Screening Initiative

Autor: Martine J. Piccart, David Venet, Matteo Benelli, Lucy R. Yates, Florentine S. Hilbers, Carmela Caballero, Andrea Vingiani, Mariana Brandão, Maite Lasa Montoya, Nadia Harbeck, David A. Cameron, Susan Knox, Sherene Loi, Philippe L. Bedard, Oskar Th Johannsson, Nancy E. Davidson, Gabriele Zoppoli, Barbro Linderholm, Sibylle Loibl, Ethel Seyll, Marta Paoli, Ásgerdur Sverrisdóttir, Richard Greil, Silvia Khodaverdi, Martina Degiorgis, Karolina Fs Larsson, Andrea Bonetti, Peter Hall, Angel Guerrero-Zotano, Hans Wildiers, Andrea Gombos, Beatriz Rojas, Dario Romagnoli, Sandrine Marreaud, Caroline Duhem, Joan Albanell, Fatima Cardoso, Marija Balic, Marco Colleoni, Jorge S. Reis-Filho, Judith M. Bliss, Giuseppe Curigliano, Elsemieke D. Scheepers, Giuseppe Viale, Evandro de Azambuja, Eva M. Ciruelos, Angelo Di Leo, Justin Ndozeng, Mark E. Robson, Einav Nili Gal-Yam, Christos Sotiriou, Debora Fumagalli, Alexandre Irrthum, Mafalda Oliveira, Philippe Aftimos

File with the supplementary material & methods, supplementary tables and supplementary figure.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a107466be99e0e8d07f33aa5227fcd
https://doi.org/10.1158/2159-8290.22540795.v1

Genomic and Transcriptomic Analyses of Breast Cancer Primaries and Matched Metastases in AURORA, the Breast International Group (BIG) Molecular Screening Initiative

Autor: Andrea Gombos, Marija Balic, Debora Fumagalli, Einav Nili Gal-Yam, Barbro Linderholm, Peter Hall, Sibylle Loibl, Mariana Brandão, Evandro de Azambuja, Christos Sotiriou, Carmela Caballero, Matteo Benelli, Alexandre Irrthum, Justin Ndozeng, Ásgerdur Sverrisdóttir, Sandrine Marreaud, Dario Romagnoli, Hans Wildiers, C. Duhem, Giuseppe Viale, Giuseppe Curigliano, Jorge S. Reis-Filho, Elsemieke D. Scheepers, Ethel Seyll, Richard Greil, Mark E. Robson, Angel Guerrero-Zotano, Beatriz Rojas, Eva M. Ciruelos, Gabriele Zoppoli, Mafalda Oliveira, Angelo Di Leo, Judith M Bliss, Joan Albanell, Oskar Th Johannsson, Philippe Aftimos, Sherene Loi, David Venet, David Cameron, Karolina Larsson, Nancy E. Davidson, Susan J. Knox, M.A. Colleoni, Nadia Harbeck, Silvia Khodaverdi, Maite Lasa Montoya, Andrea Bonetti, Florentine Hilbers, Martina Degiorgis, Fatima Cardoso, Marta Paoli, Philippe L. Bedard, Andrea Vingiani, Lucy R. Yates, Martine Piccart

Publikováno v: Scientia
Aftimos, P, Oliveira, M, Irrthum, A, Fumagalli, D, Sotiriou, C, Nili Gal-yam, E, Robson, M E, Ndozeng, J, Di Leo, A, Ciruelos, E M, De Azambuja, E, Viale, G, Scheepers, E D, Curigliano, G, Bliss, J M, Reis-filho, J S, Colleoni, M, Balic, M, Cardoso, F, Albanell, J, Duhem, C, Marreaud, S, Romagnoli, D, Rojas, B, Gombos, A, Wildiers, H, Guerrero-zotano, A, Hall, P, Bonetti, A, Larsson, K F, Degiorgis, M, Khodaverdi, S, Greil, R, Sverrisdottir, A, Paoli, M, Seyll, E, Loibl, S, Linderholm, B, Zoppoli, G, Davidson, N E, Johannsson, O T, Bedard, P L, Loi, S, Knox, S, Cameron, D A, Harbeck, N, Lasa Montoya, M, Brandão, M, Vingiani, A, Caballero, C, Hilbers, F S, Yates, L R, Benelli, M, Venet, D & Piccart, M J 2021, ' Genomic and transcriptomic analyses of breast cancer primaries and matched metastases in AURORA, the Breast International Group (BIG) molecular screening initiative ', Cancer Discovery, pp. candisc.1647.2020 . https://doi.org/10.1158/2159-8290.CD-20-1647
Cancer discovery

AURORA aims to study the processes of relapse in metastatic breast cancer (MBC) by performing multi-omics profiling on paired primary tumors and early-course metastases. Among 381 patients (primary tumor and metastasis pairs: 252 TGS, 152 RNA-Seq, 67

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::821e944dbf0a95538110529d32f6e06d
https://pubmed.ncbi.nlm.nih.gov/34183353