Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Alexandre Guilhem"'
1
Akademický článek
Pro-angiogenic changes of T-helper lymphocytes in hereditary hemorrhagic telangiectasia
Autor: Alexandre Guilhem, Marion Ciudad, Marie-Hélène Aubriot-Lorton, Hélène Greigert, Claudie Cladière, Vanessa Leguy-Seguin, Sylvain Audia, Maxime Samson, Bernard Bonnotte
Publikováno v: Frontiers in Immunology, Vol 14 (2023)
Hereditary hemorrhagic telangiectasia (HHT) is a rare inherited disease due to heterozygous loss-of-function mutations on the BMP9/10 pathway (ENG, ACVRL1 or MADH4 mainly). HHT endothelial cells are prone to lose their quiescence, leading to progress
Externí odkaz: https://doaj.org/article/8fc7267375d643fe8500fdc415098eb6
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2
Akademický článek
Altered expressions of CXCR4 and CD26 on T-helper lymphocytes in hereditary hemorrhagic telangiectasia
Autor: Alexandre Guilhem, Pierre Portalès, Sophie Dupuis-Girod, Sophie Rivière, Thierry Vincent
Publikováno v: Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-11 (2021)
Abstract Background Hereditary hemorrhagic telangiectasia (HHT) is a rare genetic disease characterized by a deregulated neo-angiogenesis. Besides a mainly vascular phenotype (muco-cutaneous telangiectases, arteriovenous malformations), a specific ri
Externí odkaz: https://doaj.org/article/413a70abe0224e6bbb2717f2df9c1e48
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3
Akademický článek
The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome
Autor: Mathieu Blot, Jean-Baptiste Bour, Jean Pierre Quenot, Abderrahmane Bourredjem, Maxime Nguyen, Julien Guy, Serge Monier, Marjolaine Georges, Audrey Large, Auguste Dargent, Alexandre Guilhem, Suzanne Mouries-Martin, Jeremy Barben, Belaid Bouhemad, Pierre-Emmanuel Charles, Pascal Chavanet, Christine Binquet, Lionel Piroth, for the LYMPHONIE study group
Publikováno v: Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-14 (2020)
Abstract Background Although immune modulation is a promising therapeutic avenue in coronavirus disease 2019 (COVID-19), the most relevant targets remain to be found. COVID-19 has peculiar characteristics and outcomes, suggesting a unique immunopatho
Externí odkaz: https://doaj.org/article/c3eeda29cace4aca802f2b4fe851cbe9
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5
Akademický článek
Intra-venous bevacizumab in hereditary hemorrhagic telangiectasia (HHT): A retrospective study of 46 patients.
Autor: Alexandre Guilhem, Anne-Emmanuelle Fargeton, Anne-Claire Simon, Pierre Duffau, Jean-Robert Harle, Christian Lavigne, Marie-France Carette, Olivier Bletry, Pierre Kaminsky, Vanessa Leguy, Nathalie Lerolle, Dominique Roux, Marc Lambert, Thierry Chinet, Delphine Bonnet, Sophie Dupuis-Girod, Sophie Rivière
Publikováno v: PLoS ONE, Vol 12, Iss 11, p e0188943 (2017)
Bevacizumab, an anti-VEGF monoclonal antibody, has recently emerged as a new option for severe forms of hereditary hemorrhagic telangiectasia (HHT). Its utilization in this orphan disease has rapidly spread despite the lack of randomized trials and i
Externí odkaz: https://doaj.org/article/acf4a8c5dee84f868f1a92cce5b9d24f
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6
Akademický článek
Efficacy and safety of dapsone as second line therapy for adult immune thrombocytopenia: A retrospective study of 42 patients.
Autor: Clémentine Estève, Maxime Samson, Alexandre Guilhem, Barbara Nicolas, Vanessa Leguy-Seguin, Sabine Berthier, Bernard Bonnotte, Sylvain Audia
Publikováno v: PLoS ONE, Vol 12, Iss 10, p e0187296 (2017)
Dapsone is recommended as a second line therapy in immune thrombocytopenia (ITP), but is underused because of its potential side effects. The medical charts of 42 ITP patients treated with dapsone (100 mg/day) were retrospectively reviewed in order t
Externí odkaz: https://doaj.org/article/5f624b92aced47b498411f46ba3327f1
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7
The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome
Autor: Lionel Piroth, Jean-Baptiste Bour, Julien Guy, P. Chavanet, Audrey Large, Auguste Dargent, Belaid Bouhemad, Jean Pierre Quenot, Jeremy Barben, Pierre-Emmanuel Charles, Maxime Nguyen, Christine Binquet, Mathieu Blot, Serge Monier, Abderrahmane Bourredjem, Alexandre Guilhem, Marjolaine Georges, Suzanne Mouries-Martin
Publikováno v: Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-14 (2020)
Journal of Translational Medicine
Background Although immune modulation is a promising therapeutic avenue in coronavirus disease 2019 (COVID-19), the most relevant targets remain to be found. COVID-19 has peculiar characteristics and outcomes, suggesting a unique immunopathogenesis.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a460b443c99135a4c9acb18c656e1a
https://doaj.org/article/c3eeda29cace4aca802f2b4fe851cbe9
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8
T-cell immune response predicts the risk of critical SARS-Cov2 infection in hospitalized COVID-19 patients
Autor: Maxime Samson, Barbara Nicolas, Marion Ciudad, Hélène Greigert, Alexandre Guilhem, Claudie Cladiere, Cécile Straub, Mathieu Blot, Lionel Piroth, Thomas Rogier, Hervé Devilliers, Patrick Manckoundia, Thibault Ghesquiere, Stéphanie Francois, Daniela Lakomy, Sylvain Audia, Bernard Bonnotte
Publikováno v: European journal of internal medicine. 102
This study aimed to identify markers of disease worsening in patients hospitalized for SARS-Cov2 infection.Patients hospitalized for severe recent-onset (1 week) SARS-Cov2 infection were prospectively included. The percentage of T-cell subsets and pl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3182c27c423c14216669028e66b432b7
https://pubmed.ncbi.nlm.nih.gov/35690570
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9
Seven cases of hereditary haemorrhagic telangiectasia-like hepatic vascular abnormalities associated withEPHB4pathogenic variants
Autor: Alexandre Guilhem, Sophie Dupuis-Girod, Olivier Espitia, Sophie Rivière, Julie Seguier, Mallorie Kerjouan, Christian Lavigne, Hélène Maillard, Pascal Magro, Laurent Alric, Dan Lipsker, Antoine Parrot, Vanessa Leguy, Claire Vanlemmens, Laurent Guibaud, Miikka Vikkula, Melanie Eyries, Pierre-Jean Valette, Sophie Giraud
Publikováno v: Journal of Medical Genetics. :jmg-2022
BackgroundEPHB4loss of function is associated with type 2 capillary malformation–arteriovenous malformation syndrome, an autosomal dominant vascular disorder. The phenotype partially overlaps with hereditary haemorrhagic telangiectasia (HHT) due to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7842476c989505af42e2da4b7f0a4f8
https://doi.org/10.1136/jmg-2022-109107
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10
Altered Expressions of CXCR4 and CD26 On T-Helper Lymphocytes in Hereditary Hemorrhagic Telangiectasia
Autor: Pierre Portales, Sophie Dupuis-Girod, Sophie Rivière, Thierry Vincent, Alexandre Guilhem
Publikováno v: Orphanet Journal of Rare Diseases
Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-11 (2021)
Orphanet Journal of Rare Diseases, BioMed Central, 2021, 16 (1), pp.511. ⟨10.1186/s13023-021-02139-y⟩
Background Hereditary hemorrhagic telangiectasia (HHT) is a rare genetic disease characterized by a deregulated neo-angiogenesis. Besides a mainly vascular phenotype (muco-cutaneous telangiectases, arteriovenous malformations), a specific risk of inf
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f4adec1d0936251e1f9beaac2c7f4a
https://doi.org/10.21203/rs.3.rs-727935/v1
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