Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Alexandre Grigoryan"'
Autor:
Prachi Anand, Alexandre Grigoryan, Mohammed H Bhuiyan, Beatrix Ueberheide, Victoria Russell, Jose Quinoñez, Patrick Moy, Brian T Chait, Sébastien F Poget, Mandë Holford
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94122 (2014)
Disulfide-rich peptide toxins found in the secretions of venomous organisms such as snakes, spiders, scorpions, leeches, and marine snails are highly efficient and effective tools for novel therapeutic drug development. Venom peptide toxins have been
Externí odkaz:
https://doaj.org/article/8f2dd5afe5164683ad9e7ebcf980ca22
Publikováno v:
Tetrahedron Lett
α-Hydroxytropolones (αHTs) have a wealth of biological activity owing to their ability to serve as metalbinding fragments for many therapeutically valuable dinuclear metalloenzymes. They also have the potential to exist in as many as 4 protonation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::324b58ba2f50b5f246ed24c769221647
https://pubmed.ncbi.nlm.nih.gov/32855576
https://pubmed.ncbi.nlm.nih.gov/32855576
Publikováno v:
Tetrahedron Letters. 60:1643-1645
α-Hydroxytropolones (αHTs) have a wealth of biological activity owing to their ability to serve as metal-binding fragments for many therapeutically valuable dinuclear metalloenzymes. They also have the potential to exist in as many as 4 protonation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ec2487ba05ef1e329a37a990cb12fed
https://doi.org/10.1016/j.tetlet.2019.05.034
https://doi.org/10.1016/j.tetlet.2019.05.034
Autor:
R. Mark L. Buller, Nathan L. Ponzar, Juan A. Villa, Lisa Wilson, R. Matt Liley, John E. Sagartz, Elena Lomonosova, Ryan P. Murelli, Kelly R. Long, John E. Tavis, John Bial, Qilan Li, Alexandre Grigoryan, Stephen R. Rapp, Erin Touchette
Chronic hepatitis B virus infection cannot be cured by current therapies, so new treatments are urgently needed. We recently identified novel inhibitors of the hepatitis B virus ribonuclease H that suppress viral replication in cell culture. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b46be5b091682b241b92f80dc87b2c5
https://europepmc.org/articles/PMC5743599/
https://europepmc.org/articles/PMC5743599/
Autor:
Anthony Zunica, John E. Tavis, Maureen J. Donlin, Alex J. Berkowitz, Ashlyn Lipnicky, Aswin K. Garimallaprabhakaran, Marvin J. Meyers, Ryan P. Murelli, Alexandre Grigoryan
Publikováno v:
Antimicrobial Agents and Chemotherapy. 61
Cryptococcus neoformans is a pathogen that is common in immunosuppressed patients. It can be treated with amphotericin B and fluconazole, but the mortality rate remains 15 to 30%. Thus, novel and more effective anticryptococcal therapies are needed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b013399b41c2e0e01e6962d4d3535c
https://doi.org/10.1128/aac.02574-16
https://doi.org/10.1128/aac.02574-16
Autor:
Alexandre Grigoryan, Sébastien F. Poget, Mohammed H. Bhuiyan, Prachi Anand, Jianqin Zhuang, Mandë Holford
Publikováno v:
Biophysical Journal. (3):607a
Peptide toxins display great specificity in both targeting and function, and are a viable resource for enriching the available arsenal of pharmaceutical compounds. For example Ziconotide (Prialt), a peptide toxin derived from cone snails (conotoxin),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff2fe3b0a74d591fcef27dca5cf44bc