Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Alexandre Gouzy"'
Autor:
Alexandre Gouzy
Publikováno v:
mSystems, Vol 8, Iss 5 (2023)
ABSTRACT The interaction between Mycobacterium tuberculosis, the agent of tuberculosis (TB), and its host cell, the macrophage, is multifaceted, dynamic, and involves multiple molecular partners. A better understanding of this interaction could help
Externí odkaz:
https://doaj.org/article/6887af3d11ab4f598c2ecc0c8e36c2fa
Autor:
Kaj M. Kreutzfeldt, Robert S. Jansen, Travis E. Hartman, Alexandre Gouzy, Ruojun Wang, Inna V. Krieger, Matthew D. Zimmerman, Martin Gengenbacher, Jansy P. Sarathy, Min Xie, Véronique Dartois, James C. Sacchettini, Kyu Y. Rhee, Dirk Schnappinger, Sabine Ehrt
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Drug tolerance complicates the treatment of tuberculosis. Here, Kreutzfeldt et al. show that the protein CinA mediates drug tolerance in Mycobacterium tuberculosis by cleaving NAD-drug adducts, suggesting CinA as a potential target to shorten tubercu
Externí odkaz:
https://doaj.org/article/0ffbbce15de04ec482009cd19552b697
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Synthesis and cleavage of the cell wall polymer peptidoglycan (PG) are carefully orchestrated processes and are essential for the growth and survival of bacteria. Yet, the function and importance of many enzymes that act on PG in Mycobacteri
Externí odkaz:
https://doaj.org/article/4f7672fe65a14e9593cd7c78b4d8f63f
Autor:
Alexandre Gouzy, Gérald Larrouy-Maumus, Daria Bottai, Florence Levillain, Alexia Dumas, Joshua B Wallach, Irène Caire-Brandli, Chantal de Chastellier, Ting-Di Wu, Renaud Poincloux, Roland Brosch, Jean-Luc Guerquin-Kern, Dirk Schnappinger, Luiz Pedro Sório de Carvalho, Yannick Poquet, Olivier Neyrolles
Publikováno v:
PLoS Pathogens, Vol 10, Iss 2, p e1003928 (2014)
Mycobacterium tuberculosis is an intracellular pathogen. Within macrophages, M. tuberculosis thrives in a specialized membrane-bound vacuole, the phagosome, whose pH is slightly acidic, and where access to nutrients is limited. Understanding how the
Externí odkaz:
https://doaj.org/article/ab8fb567ac654e6b8e1dc58688fb2b26
Pyrazinamide (PZA) is a pivotal antibiotic for the chemotherapy of tuberculosis (TB), a disease caused by the bacterium Mycobacterium tuberculosis (Mtb). PZA is notorious for its poor in vitro activity which complicates phenotypic PZA-susceptibility
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::068c8813fd5992e057230e98ca4c4a01
https://doi.org/10.1101/2022.05.22.492909
https://doi.org/10.1101/2022.05.22.492909
Autor:
Kohta Saito, Christopher D. Brown, Ellen Kaplan, Elaina Weber, Xiuju Jiang, Nico Cicchetti, Alexandre Gouzy, Carl Nathan, Thulasi Warrier, Ben Gold, Jianjie Mi, Saurabh Mishra, Julia Roberts
Publikováno v:
Science Translational Medicine. 13
Mycobacterium tuberculosis that sustains moderate oxidative damage survives undetected on solid media, but growth delay restores replicative ability.
Publikováno v:
Proc Natl Acad Sci U S A
Acidic pH arrests the growth of Mycobacterium tuberculosis in vitro (pH < 5.8) and is thought to significantly contribute to the ability of macrophages to control M. tuberculosis replication. However, this pathogen has been shown to survive and even
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c174372b3b0cac14ab0f07dfa792eb02
https://europepmc.org/articles/PMC8364206/
https://europepmc.org/articles/PMC8364206/
Publikováno v:
Nature Reviews Microbiology. 12:729-737
Several major pathogens, including Mycobacterium tuberculosis, parasitize host cells and exploit host-derived nutrients to sustain their own metabolism. Although the carbon sources that are used by M. tuberculosis have been extensively studied, the m
Publikováno v:
Future Microbiology. 9:631-637
ABSTRACT: Mycobacterium tuberculosis, the agent of TB, is a facultative intracellular bacterial pathogen that replicates inside host macrophages and other phagocytes within a membrane-bound vacuole or phagosome. How M. tuberculosis captures and explo
Publikováno v:
médecine/sciences. 30:242-244