Fragment-oriented synthesis: β-elaboration of cyclic amine fragments using enecarbamates as platform intermediates

Autor: Adam Nelson, Emily L Faulkner, Alexandre F. Trindade, Andrew G. Leach, Stephen P. Marsden

Publikováno v: Trindade, A F, Faulkner, E L, Leach, A G, Nelson, A & Marsden, S P 2020, ' Fragment-oriented synthesis: β-elaboration of cyclic amine fragments using enecarbamates as platform intermediates ', Chemical communications (Cambridge, England) . https://doi.org/10.1039/d0cc03934a

A strategy for the β-sp3 functionalisation of cyclic amines is described. Regioselective conversion of protected amines to enecarbamates is achieved through electrochemical oxidation; these intermediates can be derivatised by functionalised alkyl ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad2bef2bcb79e8570af07185529ce9a
https://doi.org/10.1039/d0cc03934a

Creating Diversity from Biomass: A Tandem Bio/Metal‐Catalysis towards Chemoselective Synthesis of Densely Substituted Furans

Autor: Alexandre F. Trindade, Svilen P. Simeonov, Giovanni Poli, João M. J. M. Ravasco, Filipa Siopa, Carlos M. Monteiro, Julie Oble, Carlos A. M. Afonso

Publikováno v: ChemSusChem
ChemSusChem, ChemPubSoc Europe/Wiley, 2019, 12 (20), pp.4629--4635. ⟨10.1002/cssc.201902051⟩

A new chemoselective (enzymatic desymmetrization/Ru-catalyzed C-H activation) sequence to obtain differently substituted furans from the largely available 2,5-furandicarboxylic acid (FDCA) was developed. Series of di- and trisubstituted furans were p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed2925e9ad3fb2accd52838c8eed04d
https://doi.org/10.1002/cssc.201902051

Bioconjugation with Maleimides: A Useful Tool for Chemical Biology

Autor: João M. J. M. Ravasco, Pedro M. P. Gois, Hélio Faustino, Alexandre F. Trindade

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 25(1)

Maleimide chemistry stands out in the bioconjugation toolbox by virtue of its synthetic accessibility, excellent reactivity, and practicability. The second-generation of clinically approved antibody-drug conjugates (ADC) and much of the current ADC p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38897eb26994fdd87dce48f549e782b5
https://pubmed.ncbi.nlm.nih.gov/30095185

Comprehensive Organic Chemistry Experiments for the Laboratory Classroom

Autor: Carlos A M Afonso, Nuno R Candeias, Dulce Pereira Simão, Alexandre F Trindade, Jaime A S Coelho, Bin Tan, Robert Franzén

This expansive and practical textbook contains organic chemistry experiments for teaching in the laboratory at the undergraduate level covering a range of functional group transformations and key organic reactions.The editorial team have collected co

3.1.7. Preparation of a Sulfathiazole Prodrug via N-acylation with Succinic Anhydride

Autor: Pedro M. P. Gois, Francisca Lopes, Alexandre F. Trindade

Publikováno v: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom ISBN: 9781849739634

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ca8efbe42424d5c6b1babe902341ad2
https://doi.org/10.1039/9781849739634-00151