AChR β-Subunit mRNAs Are Stabilized by HuR in a Mouse Model of Congenital Myasthenic Syndrome With Acetylcholinesterase Deficiency

Autor: Perrine Delers, Claire Legay, Alexandre Dobbertin, Guy Bélanger, Fannie Semprez, Aymeric Ravel-Chapuis, Nouha Soyed, Julie Areias, Jennifer Karmouch, Bernard J. Jasmin

Publikováno v: Frontiers in Molecular Neuroscience, Vol 13 (2020)
Frontiers in Molecular Neuroscience

Collagen Q (COLQ) is a specific collagen that anchors acetylcholinesterase (AChE) in the synaptic cleft of the neuromuscular junction. So far, no mutation has been identified in the ACHE human gene but over 50 different mutations in the COLQ gene are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5283314b7605a362cfd96c11aa55b0c

Contributions of selective knockout studies to understanding cholinesterase disposition and function

Autor: Oksana Lockridge, Shelley Camp, Véronique Bernard, Palmer Taylor, Antonella De Jaco, Ellen G. Duysen, Limin Zhang, Emmanuelle Girard, Alexandre Dobbertin, Eric Krejci

Publikováno v: Chemico-Biological Interactions
Chemico-Biological Interactions, Elsevier, 2010, 187 (1-3), pp.72-77. ⟨10.1016/j.cbi.2010.02.008⟩

International audience; The complete knockout of the acetylcholinesterase gene (AChE) in the mouse yielded a surprising phenotype that could not have been predicted from deletion of the cholinesterase genes in Drosophila, that of a living, but functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::865f641f1adaf8a10ddc7237b1979ebc
https://doi.org/10.1016/j.cbi.2010.02.008

MuSK frizzled-like domain is critical for mammalian neuromuscular junction formation and maintenance

Autor: Julien Messéant, Marin Manuel, Daniel Zytnicki, Alexandre Dobbertin, Laurent Schaeffer, Claire Legay, Alain Schmitt, Perrine Delers, Emmanuelle Girard, Francesca Mangione, Laure Strochlic, Dominique Le Denmat, Jordi Molgó

Publikováno v: Journal of Neuroscience
Journal of Neuroscience, Society for Neuroscience, 2015, 35 (12), pp.4926-41. ⟨10.1523/JNEUROSCI.3381-14.2015⟩
Journal of Neuroscience, 2015, 35 (12), pp.4926-41. ⟨10.1523/JNEUROSCI.3381-14.2015⟩
Journal of Neuroscience, Society for Neuroscience, 2015, 35 (12), pp.4926-41. 〈10.1523/JNEUROSCI.3381-14.2015〉

The muscle-specific kinase MuSK is one of the key molecules orchestrating neuromuscular junction (NMJ) formation. MuSK interacts with the Wnt morphogens, through its Frizzled-like domain (cysteine-rich domain [CRD]). Dysfunction of MuSK CRD in patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8930ffe5b501706527a9cfede5e2d3
https://hal.archives-ouvertes.fr/hal-01165625

Activation of ionotropic glutamate receptors reduces the production of transforming growth factor-ß2 by developing neurons

Autor: Jacques Glowinski, Annie Gervais, Alexandre Dobbertin, Michel Mallat

Publikováno v: European Journal of Neuroscience. 12:4589-4593

Neuronal cultures derived from developing rat cerebral cortex were used to investigate the influence of glutamate receptors on the neuronal production of transforming growth factor-beta2 (TGFbeta2), a multifunctional cytokine that modulates neuronal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2af13f80001108d348ab7ec0a2f0dbbd
https://doi.org/10.1046/j.0953-816x.2000.01354.x

Identification of CSF-1 as a brain macrophage migratory activity produced by astrocytes

Autor: Michel Mallat, Charles-Félix Calvo, Jacques Glowinski, Michèle Gelman, Alexandre Dobbertin

Publikováno v: Glia. 24:180-186

Intraparenchymal migration of macrophages occurs in the CNS during development or as a consequence of tissue injuries. In the present study, we have shown, by using an in vitro chemotaxis assay, that cultured rat astrocytes obtained from the developi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5911a09e4937a20d18bd30119cce9b
https://doi.org/10.1002/(sici)1098-1136(199810)24:2<180::aid-glia3>3.0.co