Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Alexandre Chigaev"'
Autor:
Julia C. Gutjahr, Elisabeth Bayer, Xiaobing Yu, Julia M. Laufer, Jan P. Höpner, Suzana Tesanovic, Andrea Härzschel, Georg Auer, Tanja Rieß, Astrid Salmhofer, Eva Szenes, Theresa Haslauer, Valerie Durand-Onayli, Andrea Ramspacher, Sandra P. Pennisi, Marc Artinger, Nadja Zaborsky, Alexandre Chigaev, Fritz Aberger, Daniel Neureiter, Lisa Pleyer, Daniel F. Legler, Veronique Orian-Rousseau, Richard Greil, Tanja N. Hartmann
Publikováno v:
Haematologica, Vol 106, Iss 8 (2020)
Adhesive properties of leukemia cells shape the degree of organ infiltration and the extent of leukocytosis. CD44 and the integrin VLA-4, a CD49d/CD29 heterodimer, are important factors of progenitor cell adhesion in bone marrow (BM). Here, we report
Externí odkaz:
https://doaj.org/article/9bf54160724d40848f05cabcbde9c7ee
Publikováno v:
Semin Cancer Biol
While current treatment regimens for acute leukemia can dramatically improve patient survival, there remains room for improvement. Due to its roles in cell differentiation, cell survival, and apoptotic signaling, modulation of the cyclic AMP (cAMP) p
Autor:
Barbara De Moerloose, Serge Van Calenbergh, Wojciech Ornatowski, Steven Goossens, Sofie Peirs, Alexandre Chigaev, Wouter Van Loocke, Charles G. Mullighan, Pieter Van Vlierberghe, Christian K. Nickl, Takeshi Takarada, Mignon L. Loh, Eliseo F. Castillo, Laurence C. Cheung, Dominique Perez, Béatrice Lintermans, Yukio Yoneda, Frederik W. van Delft, Richard B. Lock, Stuart S. Winter, Juliette Roels, Stephen P. Hunger, Lisa Demoen, Lindy Reunes, Ksenia Matlawska-Wasowska, Larry A. Sklar, Monique Nysus, Rishi S. Kotecha, Tim Lammens, Huining Kang, Dieter Deforce, Tim Pieters, Nitesh D. Sharma, Filip Van Nieuwerburgh, Martijn D. P. Risseeuw, Seth D. Merkley, Filip Matthijssens
Publikováno v:
J Clin Invest
JOURNAL OF CLINICAL INVESTIGATION
JOURNAL OF CLINICAL INVESTIGATION
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with inferior outcome compared with that of B cell ALL. Here, we show that Runt-related transcription factor 2 (RUNX2) was upregulated in high-risk T-ALL with KMT2A r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7320b73d3d90f1b61255b31a6ace270f
https://europepmc.org/articles/PMC7954605/
https://europepmc.org/articles/PMC7954605/
Autor:
Marc Artinger, Véronique Orian-Rousseau, Lisa Pleyer, Fritz Aberger, Suzana Tesanovic, Elisabeth Bayer, Daniel Neureiter, Andrea Härzschel, Valerie Durand-Onayli, Tanja Rieß, Jan Philip Höpner, Alexandre Chigaev, Georg Auer, Julia Christine Gutjahr, Nadja Zaborsky, Richard Greil, Daniel F. Legler, Julia M. Laufer, Sandra Pennisi, Astrid Salmhofer, Xiaobing Yu, Andrea Ramspacher, Tanja Nicole Hartmann, Theresa Haslauer, Eva Szenes
Publikováno v:
Haematologica, 106 (8), 2102-2113
Haematologica
Haematologica
Adhesive properties of leukemia cells shape the degree of organ infiltration and the extent of leukocytosis. CD44 and the integrin VLA-4, a CD49d/CD29 heterodimer, are important factors of progenitor cell adhesion in bone marrow (BM). Here, we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7bde17c88e6e52bc9f73a02d5ff2aa8
https://publikationen.bibliothek.kit.edu/1000127084
https://publikationen.bibliothek.kit.edu/1000127084
Autor:
Tanja Nicole Hartmann, Ayed O. Ayed, Alexandre Chigaev, Valter Gattei, Gabriele Pozzato, Antonella Zucchetto, Enrico Santinelli, Jan A. Burger, Julia Christine Gutjahr, Massimiliano Postorino, Elisabeth Bayer, Erika Tissino, Riccardo Bomben, Giovanni Del Poeta, Michele Dal Bo, Adrian Wiestner, Elisa Ten Hacken, Dania Benedetti, Pietro Bulian, Inhye E. Ahn, Larry A. Sklar, Andrea Härzschel, Alessandra Ferrajoli, Francesca Rossi, Kari G. Chaffee, Annalisa Chiarenza, Francesco Zaja, Tait D. Shanafelt, Sarah E. M. Herman
Publikováno v:
The Journal of Experimental Medicine
Tissino et al. demonstrate that in chronic lymphocytic leukemia, the VLA-4 (CD49d/CD29) integrin remains activable by B cell receptor stimulation also upon in vitro and in vivo ibrutinib exposure. Clinically, ibrutinib-treated CD49d-positive CLL pati
Publikováno v:
Pharmacol Ther
Clioquinol, one of the first mass-produced drugs, was considered safe and efficacious for many years. It was used as an antifungal and an antiprotozoal drug until it was linked to an outbreak of subacute myelo-optic neuropathy (SMON), a debilitating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b03edcb31559402a6925d701aff89a09
https://europepmc.org/articles/PMC6571072/
https://europepmc.org/articles/PMC6571072/
Autor:
Alexandre Chigaev, Ksenia Matlawska-Wasowska, Stuart S. Winter, Annette M. Evangelisti, Mark B. Carter, Larry A. Sklar, Matthew Garcia, Yelena Smagley, Dominique Perez
Publikováno v:
Oncotarget
// Dominique R. Perez 1,2,3 , Yelena Smagley 1,2 , Matthew Garcia 1,2 , Mark B. Carter 1,2 , Annette Evangelisti 1,2,3 , Ksenia Matlawska-Wasowska 1,4 , Stuart S. Winter 1,4 , Larry A. Sklar 1,2,3 and Alexandre Chigaev 1,2,3 1 University of New Mexic
Publikováno v:
Methods in Molecular Biology ISBN: 9781493988754
The integrin heterodimer CD49d/CD29 (a.k.a. Very Late Antigen-4, VLA-4) mediates cell-cell and cell-matrix interaction through the binding of its ligands VCAM-1 and fibronectin. VLA-4 can be present on the cell surface at different conformation state
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31163b580752e223ab4d0c6ab7399b91
https://doi.org/10.1007/978-1-4939-8876-1_8
https://doi.org/10.1007/978-1-4939-8876-1_8
Autor:
Pischeli Justine, Erika Tissino, Jan Philip Höpner, Alexandre Chigaev, Alexander Egle, Sandra Pennisi, Valter Gattei, Julia Christine Gutjahr, Christine Dierks, Nadja Zaborsky, Richard Greil, Marie Follo, Eva Szenes, Andrea Härzschel, Antonella Zucchetto, Sarah Decker, Tanja Nicole Hartmann
Publikováno v:
Blood. 134:1730-1730
Introduction. Ibrutinib, a small molecule inhibitor of Bruton's tyrosine kinase (BTK), has proven to be an efficient treatment for chronic lymphocytic leukemia (CLL). A distinct characteristic of ibrutinib therapy is transient lymphocytosis. Recently
Autor:
Annalisa Chiarenza, Pietro Bulian, Tanja Nicole Hartmann, Larry A. Sklar, Valter Gattei, Erika Tissino, Francesca Rossi, Antonella Nicolò, Hassan Jumaa, Alexandre Chigaev, Francesco Zaja, Riccardo Bomben, Gabriela Forestieri, Giovanni D'Arena, Moumita Datta, Giovanni Del Poeta, Tamara Bittolo, Antonella Zucchetto, Enrico Santinelli, Palash Chandra Maity, Gabriele Pozzato, Andrea Härzschel, Davide Rossi, Dania Benedetti, Francesco Di Raimondo
Publikováno v:
Blood. 134:849-849
Introduction. In chronic lymphocytic leukemia (CLL), CD49d, the alpha chain of the heterodimer CD49d/CD29 (VLA-4), is a strong negative prognosticator, and a key player of CLL microenvironmental interactions. The adhesive properties of VLA-4 can be r