Zobrazeno 1 - 10
of 218
pro vyhledávání: '"Alexandre Carpentier"'
Autor:
Víctor A. Arrieta, Andrew Gould, Kwang-Soo Kim, Karl J. Habashy, Crismita Dmello, Gustavo I. Vázquez-Cervantes, Irina Palacín-Aliana, Graysen McManus, Christina Amidei, Cristal Gomez, Silpol Dhiantravan, Li Chen, Daniel Y. Zhang, Ruth Saganty, Meghan E. Cholak, Surya Pandey, Matthew McCord, Kathleen McCortney, Brandyn Castro, Rachel Ward, Miguel Muzzio, Guillaume Bouchoux, Carole Desseaux, Michael Canney, Alexandre Carpentier, Bin Zhang, Jason M. Miska, Maciej S. Lesniak, Craig M. Horbinski, Rimas V. Lukas, Roger Stupp, Catalina Lee-Chang, Adam M. Sonabend
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Given the marginal penetration of most drugs across the blood-brain barrier, the efficacy of various agents remains limited for glioblastoma (GBM). Here we employ low-intensity pulsed ultrasound (LIPU) and intravenously administered microbub
Externí odkaz:
https://doaj.org/article/79679c002d644430b29884550815aa26
Autor:
Pierre Bourdaud, Nathalie Niquil, Emma Araignous, Henrique Cabral, Alexandre Carpentier, Hilaire Drouineau, Jérémy Lobry, Laure Pecquerie, Blanche Saint-Béat, Géraldine Lassalle, Marie Vagner
Publikováno v:
Frontiers in Ecology and Evolution, Vol 12 (2024)
Numerous threats affect aquatic ecosystems at different biological organizational levels from individuals to ecosystems. Stresses occurring on the metabolism and physiological functions of individuals can have repercussions on the individual behavior
Externí odkaz:
https://doaj.org/article/2cf245998cfc4f38b11ecd6f0215d75d
Autor:
Anne-Sophie Montero, Ilyes Aliouat, Matthieu Ribon, Michael Canney, Lauriane Goldwirt, Samia Mourah, Félix Berriat, Christian S. Lobsiger, Pierre-François Pradat, François Salachas, Gaëlle Bruneteau, Alexandre Carpentier, Séverine Boillée
Publikováno v:
EBioMedicine, Vol 106, Iss , Pp 105235- (2024)
Summary: Background: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by a progressive loss of motor neurons. The limited efficacy of recent therapies in clinical development may be linked to lack of drug penetra
Externí odkaz:
https://doaj.org/article/829c21513bc04088ba5edb899d13fb89
Autor:
Alexandre Carpentier, Roger Stupp, Adam M. Sonabend, Henry Dufour, Olivier Chinot, Bertrand Mathon, François Ducray, Jacques Guyotat, Nathalie Baize, Philippe Menei, John de Groot, Jeffrey S. Weinberg, Benjamin P. Liu, Eric Guemas, Carole Desseaux, Charlotte Schmitt, Guillaume Bouchoux, Michael Canney, Ahmed Idbaih
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Here, the results of a phase 1/2 single-arm trial (NCT03744026) assessing the safety and efficacy of blood-brain barrier (BBB) disruption with an implantable ultrasound system in recurrent glioblastoma patients receiving carboplatin are repo
Externí odkaz:
https://doaj.org/article/e712a20f4c934b6c8309df6f0e891005
Autor:
Anne Lizé, Nils Teichert, Jean-Marc Roussel, Anthony Acou, Eric Feunteun, Alexandre Carpentier
Publikováno v:
Frontiers in Ecology and Evolution, Vol 11 (2023)
Competition arises when species share a limited resource, but this can be avoided through niche partitioning. Despite the large body of literature on diadromous fishes, very few studies have focused on niche partitioning when competing for resources.
Externí odkaz:
https://doaj.org/article/53a40084330c4d77a9dc5133af5977d7
Autor:
Sébastien GALLET, Manuel SALGUEIRO-SIMON, Anthony STURBOIS, Guillaume GÉLINAUD, Marion BOURRHIS, Xavier DAUVERGNE, Alexandre CARPENTIER, Julien PÉTILLON, Célia DÈBRE
Publikováno v:
Sciences, Eaux & Territoires, Iss 41 (2023)
Le programme de recherche sur la pertinence environnementale de la restauration des petits marais et prés salés (PEPPS, 2018-2021) est issu des échanges et réflexions de chercheurs des universités de Rennes 1, de Bretagne Occidentale et de Breta
Externí odkaz:
https://doaj.org/article/3e5557fadab84f9ebaa4130fde0641e8
Autor:
Stéphane Epelbaum, Ninon Burgos, Michael Canney, Dawn Matthews, Marion Houot, Mathieu D. Santin, Carole Desseaux, Guillaume Bouchoux, Sebastian Stroer, Cyril Martin, Marie-Odile Habert, Marcel Levy, Aicha Bah, Karine Martin, Benoît Delatour, Maximilien Riche, Bruno Dubois, Lisa Belin, Alexandre Carpentier
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-13 (2022)
Abstract Background Temporary disruption of the blood-brain barrier (BBB) using pulsed ultrasound leads to the clearance of both amyloid and tau from the brain, increased neurogenesis, and mitigation of cognitive decline in pre-clinical models of Alz
Externí odkaz:
https://doaj.org/article/29d7dca3f8e04379b08a640dfa589efc
Autor:
Amandine Géraudie, Maximilien Riche, Thaïs Lestra, Alexandre Trotier, Léo Dupuis, Bertrand Mathon, Alexandre Carpentier, Benoît Delatour
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12411 (2023)
Alzheimer’s disease (AD) is the leading cause of dementia. No treatments have led to clinically meaningful impacts. A major obstacle for peripherally administered therapeutics targeting the central nervous system is related to the blood–brain bar
Externí odkaz:
https://doaj.org/article/69bbfd7ab4294946b4d89af7e6e7a541
Efficacy and Safety of Low-Intensity Pulsed Ultrasound-Induced Blood–Retinal Barrier Opening in Mice
Autor:
Alexandre Bourdin, Manon Ortoli, Remi Karadayi, Lauriane Przegralek, Florian Sennlaub, Bahram Bodaghi, Xavier Guillonneau, Alexandre Carpentier, Sara Touhami
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1896 (2023)
Systemic drugs can treat various retinal pathologies such as retinal cancers; however, their ocular diffusion may be limited by the blood–retina barrier (BRB). Sonication corresponds to the use of ultrasound (US) to increase the permeability of cel
Externí odkaz:
https://doaj.org/article/a98f9fdf1c9949729a1c8b827ac1e1ea
Autor:
Mohammed H. Ahmed, Isaias Hernández-Verdin, Emie Quissac, Nolwenn Lemaire, Coralie Guerin, Lea Guyonnet, Noël Zahr, Laura Mouton, Mathieu Santin, Alexandra Petiet, Charlotte Schmitt, Guillaume Bouchoux, Michael Canney, Marc Sanson, Maïté Verreault, Alexandre Carpentier, Ahmed Idbaih
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 455 (2023)
Therapeutic antibodies targeting immune checkpoints have shown limited efficacy in clinical trials in glioblastoma (GBM) patients. Ultrasound-mediated blood–brain barrier opening (UMBO) using low-intensity pulsed ultrasound improved drug delivery t
Externí odkaz:
https://doaj.org/article/6214fb5f9f334bc28d5749b082bc56c0