Esterification of p-Coumaric Acid Improves the Control over Melanoma Cell Growth

Autor: Joana I. Carmo-Martins, Michelangelo B. Gonzatti, Marina T. Varela, Maria Eduarda P. Sousa, Lucas V. S. Costa, Elaine Guadelupe Rodrigues, João Paulo S. Fernandes, Alexandre C. Keller

Publikováno v: Biomedicines, Vol 11, Iss 1, p 196 (2023)

Previous studies reported that p-coumaric acid modulates melanoma growth. Because the esterification of p-coumaric acid (p-CA) enhanced its activity as an antimelanogenic agent, we aimed to determine the antitumor potential of two derivatives, the et

Externí odkaz: https://doaj.org/article/e9357751776e48a8a18f0a72fc4cdde7

Invariant Natural Killer T cells resilience to paradoxical sleep deprivation-associated stress

Autor: Alexandre S. Basso, Beatriz M. Freire, Edgar Ruz Fernandes, Michelangelo Bauwelz Gonzatti, Alexandre C. Keller, Maria Eduarda Perrud Sousa, Monica L. Andersen, Daniela Santoro Rosa, Marcia G. Guereschi

Publikováno v: Brain, Behavior, and Immunity. 90:208-215

Although several studies demonstrate that stressful situations, such as sleep disturbances, negatively impact the innate and adaptive arms of the immune system, their influence on invariant Natural Killer T (iNKT) cells remains unclear. iNKT cells ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d31ec40c1466fe23a57efe2c3ba5c7
https://doi.org/10.1016/j.bbi.2020.08.018

Invariant Natural Killer T Cells as Key Players in Host Resistance against Paracoccidioides brasiliensis

Autor: Flávio V. Loures, Alessandra S. Schanoski, Joes Nogueira-Neto, Bruno C. Vivanco, Tania Alves da Costa, Vera Lúcia Garcia Calich, Alexandre C. Keller, David A. G. Andrade, Daniela Santoro Rosa, Michelangelo Bauwelz Gonzatti, Patricia Xander

Publikováno v: Journal of Immunology Research, Vol 2021 (2021)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Invariant Natural Killer T (iNKT) cells are key players in the immunity to several pathogens; however, their involvement in the resistance to Paracoccidioides brasiliensis infection remains unknown. Using splenocytes from CD1d (CD1d-/-) and iNKT-defi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1543368f8cbcce7e3c796c80ddf15e2

Sleep Disturbance During Infection Compromises Tfh Differentiation: Impact on Host Immunity

Autor: Daniela Santoro Rosa, Alexandre C. Keller, Juliana de Souza Apostólico, Marcelo Pires Amaral, Fernando Bandeira Sulczewski, Edgar Ruz Fernandes, Silvia Beatriz Boscardin, Marcela Luize Barbosa, Monica L. Andersen

Publikováno v: SSRN Electronic Journal.

Although the influence of sleep quality on the immune system is well documented, the mechanisms behind its impact on natural host immunity remain unclear. To evaluate the impact of sleep quality on host immunity against a life-threatening parasitic i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::523f4a0fc4737b15694ccb84c7de4eca
https://doi.org/10.2139/ssrn.3651512

Induction of heme oxygenase-1 can halt and even reverse renal tubule-interstitial fibrosis.

Autor: Matheus Correa-Costa, Patricia Semedo, Ana Paula F S Monteiro, Reinaldo C Silva, Rafael L Pereira, Giselle M Gonçalves, Georgia Daniela Marcusso Marques, Marcos A Cenedeze, Ana C G Faleiros, Alexandre C Keller, Maria H M Shimizu, Antônio C Seguro, Marlene A Reis, Alvaro Pacheco-Silva, Niels O S Câmara

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e14298 (2010)

The tubule-interstitial fibrosis is the hallmark of progressive renal disease and is strongly associated with inflammation of this compartment. Heme-oxygenase-1 (HO-1) is a cytoprotective molecule that has been shown to be beneficial in various model

Externí odkaz: https://doaj.org/article/8c64beab33424f85a8a87f14fb5ef35e