Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Alexandre Budu"'
Autor:
Vera S. C. Maia, Rodrigo Berzaghi, Denise C. Arruda, Fabrício C. Machado, Leticia L. Loureiro, Pollyana M. S. Melo, Alice S. Morais, Alexandre Budu, Luiz R. Travassos
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Malignant melanoma is the main cause of death in patients with skin cancer. Overexpression of Proteolipid protein 2 (PLP2) increased tumor metastasis and the knockdown of PLP2 inhibited the growth and metastasis of melanoma cells. In the pre
Externí odkaz:
https://doaj.org/article/2eba05a1f58f4d17ba9257b2a26b3996
Autor:
Gabriel Rufino Estrela, Raisa Brito Santos, Alexandre Budu, Adriano Cleis de Arruda, Jonatan Barrera-Chimal, Ronaldo Carvalho Araújo
Publikováno v:
Biomedicines, Vol 11, Iss 8, p 2194 (2023)
Background: Chronic kidney disease (CKD) is a multifactorial, world public health problem that often develops as a consequence of acute kidney injury (AKI) and inflammation. Strategies are constantly sought to avoid and mitigate the irreversibility o
Externí odkaz:
https://doaj.org/article/a78e2a2826e24ff2bd86642872f54fe0
Autor:
Sarah El Chamy Maluf, Marcelo Yudi Icimoto, Pollyana Maria Saud Melo, Alexandre Budu, Rita Coimbra, Marcos Leoni Gazarini, Adriana Karaoglanovic Carmona
Publikováno v:
Malaria Journal, Vol 19, Iss 1, Pp 1-10 (2020)
Abstract Background The intra-erythrocytic development of the malaria parasite Plasmodium falciparum depends on the uptake of a number of essential nutrients from the host cell and blood plasma. It is widely recognized that the parasite imports low m
Externí odkaz:
https://doaj.org/article/87efd33c13dc411baf4741971195b93b
Autor:
Poliana E Correia, Clarissa B Gomes, Vinicius A Bandeira, Thais Marten, Gabriella R Natividade, Paula Merello, Erica Tozawa, Carlos T S Cerski, Alexandre Budu, Ronaldo Araújo, Bruno D Arbo, Maria Flávia M Ribeiro, Carlos C Barros, Fernando Gerchman
Publikováno v:
PLoS ONE, Vol 17, Iss 5, p e0267845 (2022)
The kallikrein-kinin system has been implicated in body weight and glucose homeostasis. Their major effectors act by binding to the kinin B2 and B1 receptors. It was assessed the role of the kinin B1 receptor in weight and glucose homeostasis in B1 r
Externí odkaz:
https://doaj.org/article/202937ed49de4fcdad48df0c84de2f20
Autor:
Carolina C. Hoff, Mauro F. Azevedo, Adriana B. Thurler, Sarah El Chamy Maluf, Pollyana M. S. Melo, Maday Alonso del Rivero, Jorge González-Bacerio, Adriana K. Carmona, Alexandre Budu, Marcos L. Gazarini
Publikováno v:
Pathogens, Vol 10, Iss 11, p 1452 (2021)
Plasmodium falciparum, the most virulent of the human malaria parasite, is responsible for high mortality rates worldwide. We studied the M1 alanyl-aminopeptidase of this protozoan (PfA-M1), which is involved in the final stages of hemoglobin cleavag
Externí odkaz:
https://doaj.org/article/a0d20a6310e044c2a2d8837dadf331db
Autor:
Gabriel Rufino Estrela, Leandro Ceotto Freitas-Lima, Alexandre Budu, Adriano Cleis de Arruda, Mauro Sergio Perilhão, Ricardo Ambrósio Fock, Jonatan Barrera-Chimal, Ronaldo Carvalho Araújo
Publikováno v:
Biomedicines, Vol 9, Iss 7, p 769 (2021)
Anemia is a common feature of chronic kidney disease (CKD). It is a process related to erythropoietin deficiency, shortened erythrocyte survival, uremic erythropoiesis inhibitors, and disordered iron homeostasis. Animal models of CKD-induced anemia a
Externí odkaz:
https://doaj.org/article/0f5da22b70094abcb1ef1fb492d0ed82
Autor:
Paula Andréa Malveira Cavalcante, Natalia Alenina, Alexandre Budu, Leandro Ceotto Freitas-Lima, Thaís Alves-Silva, Juan Sebastian Henao Agudelo, Fatimunnisa Qadri, Niels Olsen Saraiva Camara, Michael Bader, Ronaldo Carvalho Araújo
Publikováno v:
Mediators of Inflammation, Vol 2019 (2019)
Macrophages contribute to a continuous increase in blood pressure and kidney damage in hypertension, but their polarization status and the underlying mechanisms have not been clarified. This study revealed an important role for M2 macrophages and the
Externí odkaz:
https://doaj.org/article/ae7f7cf7ad154c8db14e626b663c5b94
Autor:
Leandro Ceotto Freitas-Lima, Alexandre Budu, Adriano Cleis Arruda, Mauro Sérgio Perilhão, Jonatan Barrera-Chimal, Ronaldo Carvalho Araujo, Gabriel Rufino Estrela
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7416 (2020)
Cisplatin is a chemotherapy drug widely used in the treatment of solid tumors. However, nephrotoxicity has been reported in about one-third of patients undergoing cisplatin therapy. Proximal tubules are the main target of cisplatin toxicity and cellu
Externí odkaz:
https://doaj.org/article/bdc018d8796b42278a2aae4172714f5d
Autor:
Gabriel Rufino Estrela, Adriano Cleis Arruda, Heron Fernandes Vieira Torquato, Leandro Ceotto Freitas-Lima, Mauro Sérgio Perilhão, Frederick Wasinski, Alexandre Budu, Ricardo Ambrósio Fock, Edgar Julian Paredes-Gamero, Ronaldo Carvalho Araujo
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 14, p 5050 (2020)
Hypercholesterolemia, also called high cholesterol, is a form of hyperlipidemia, which may be a consequence of diet, obesity or diabetes. In addition, increased levels of low-density lipoprotein (LDL) and reduced levels of high-density lipoprotein (H
Externí odkaz:
https://doaj.org/article/1f244ff38cc44829833d5057ecaf9217
Autor:
Adriano Cleis Arruda, Mauro Sérgio Perilhão, Warley Almeida Santos, Marcos Fernandes Gregnani, Alexandre Budu, José Cesar Rosa Neto, Gabriel Rufino Estrela, Ronaldo Carvalho Araujo
Publikováno v:
Molecules, Vol 25, Iss 2, p 392 (2020)
Metformin is the first-line drug for type 2 diabetes mellitus control. It is established that this drug traffics through OCT-2 and MATE-1 transporters in kidney tubular cells and is excreted in its unaltered form in the urine. Hereby, we provide evid
Externí odkaz:
https://doaj.org/article/26acfe0eb242492ea9d17ba97418b757