Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Alexandre Bonet"'
Autor:
Irene Pachón Angona, Helene Martin, Solene Daniel, Ignacio Moraleda, Alexandre Bonet, Artur Wnorowski, Maciej Maj, Krzysztof Jozwiak, Isabel Iriepa, Bernard Refouvelet, José Marco-Contelles, Lhassane Ismaili
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 20, p 7652 (2020)
We report herein the design, synthesis, biological evaluation, and molecular modelling of new inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), able to block Ca+2 channels also showing antioxidant and neuroprotective activi
Externí odkaz:
https://doaj.org/article/5b73fff50c8c4937a77a76dd85a55f53
Autor:
Irene Pachòn Angona, Solene Daniel, Helene Martin, Alexandre Bonet, Artur Wnorowski, Maciej Maj, Krzysztof Jóźwiak, Tiago Barros Silva, Bernard Refouvelet, Fernanda Borges, José Marco-Contelles, Lhassane Ismaili
Publikováno v:
Molecules, Vol 25, Iss 6, p 1329 (2020)
We report herein the design, synthesis and biological evaluation of new antioxidant and neuroprotective multitarget directed ligands (MTDLs) able to block Ca2+ channels. New dialkyl 2,6-dimethyl-4-(4-(prop-2-yn-1-yloxy)phenyl)-1,4-dihydropyridine-3,5
Externí odkaz:
https://doaj.org/article/5b1ff1d189734033aeb82bc9f2efc13b
Autor:
Youssef Dgachi, Oscar M. Bautista-Aguilera, Mohamed Benchekroun, Hélène Martin, Alexandre Bonet, Damijan Knez, Justyna Godyń, Barbara Malawska, Stanislav Gobec, Mourad Chioua, Jana Janockova, Ondrej Soukup, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili
Publikováno v:
Molecules, Vol 21, Iss 5, p 634 (2016)
We report herein the straightforward two-step synthesis and biological assessment of novel racemic benzochromenopyrimidinones as non-hepatotoxic, acetylcholinesterase inhibitors with antioxidative properties. Among them, compound 3Bb displayed a mixe
Externí odkaz:
https://doaj.org/article/275dbed00fe84937878fb5586f6d45ed
Autor:
Houssem Boulebd, Lhassane Ismaili, Manuela Bartolini, Abdelmalek Bouraiou, Vincenza Andrisano, Helene Martin, Alexandre Bonet, Ignacio Moraleda, Isabel Iriepa, Mourad Chioua, Ali Belfaitah, José Marco-Contelles
Publikováno v:
Molecules, Vol 21, Iss 4, p 400 (2016)
Herein we describe the synthesis and in vitro biological evaluation of thirteen new, racemic, diversely functionalized imidazo pyranotacrines as non-hepatotoxic, multipotent tacrine analogues. Among these compounds, 1-(5-amino-2-methyl-4-(1-methyl-1H
Externí odkaz:
https://doaj.org/article/6e6592f9708c4f318ef1cdeb88c16b34
Autor:
Artur Wnorowski, Fernanda Borges, Hélène Martin, José Marco-Contelles, Bernard Refouvelet, Maciej Maj, Tiago H. Silva, Solene Daniel, Lhassane Ismaili, Irene Pachón Angona, Krzysztof Jóźwiak, Alexandre Bonet
Publikováno v:
Molecules, Vol 25, Iss 6, p 1329 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Molecules
Digital.CSIC. Repositorio Institucional del CSIC
instname
Molecules
We report herein the design, synthesis and biological evaluation of new antioxidant and neuroprotective multitarget directed ligands (MTDLs) able to block Ca2+ channels. New dialkyl 2,6-dimethyl-4-(4-(prop-2-yn-1-yloxy)phenyl)-1,4-dihydropyridine-3,5
Autor:
Jose Louis Marco Contelles, Hélène Martin, Ali Belfaitah, Lhassane Ismaili, Mourad Chioua, Alexandre Bonet, Houssem Boulebd
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Aim: Due to the multifactorial nature of Alzheimer's disease, there is an urgent search for new more efficient, multitarget-directed drugs. Results: This paper describes the synthesis, antioxidant and in vitro biological evaluation of ten (benz)imida
Autor:
Isabel Iriepa, Youssef Dgachi, Fakher Chabchoub, Lhassane Ismaili, José Marco-Contelles, Mourad Chioua, Alexandre Bonet, Hélène Martin, Ignacio Moraleda
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Aim: Due to the complex nature of Alzheimer's disease, there is a renewed search for multitarget directed drugs. Results: This paper describes the synthesis and in vitro biological evaluation of six racemic 13-aryl-2,3,4,13-tetrahydro-1H,12H-benzo[6,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bdad678fa89f0e96cb9508bbfd94901
http://hdl.handle.net/10261/153671
http://hdl.handle.net/10261/153671
Autor:
Lhassane Ismaili, Ondrej Soukup, Fakher Chabchoub, Jana Janockova, Ignacio Moraleda, Hélène Martin, Cristina García-Iriepa, José Marco-Contelles, Isabel Iriepa, Barbara Malawska, Alexandre Bonet, Youssef Dgachi, Lysiane Richert, Dawid Panek, Olga Sokolov, Justyna Godyń, Vincent Luzet
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Herein we report an efficient two step synthesis and biological assessment of 12 racemic tetrahydropyranodiquinolin-8-amines derivatives as antioxidant, cholinesterase inhibitors and non-hepatotoxic agents. Based on the results of the primary screeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f074fac087af99ac630e3b71eb837d
https://ruj.uj.edu.pl/xmlui/handle/item/118897
https://ruj.uj.edu.pl/xmlui/handle/item/118897
Autor:
Alexandre Bonet, Damijan Knez, Oscar M. Bautista-Aguilera, Fakher Chabchoub, Barbara Malawska, Jana Janockova, Hélène Martin, Stanislav Gobec, Ondrej Soukup, Mohamed Benchekroun, Mourad Chioua, Youssef Dgachi, Justyna Godyń, Lhassane Ismaili, José Marco-Contelles
Publikováno v:
Molecules; Volume 21; Issue 5; Pages: 634
Molecules, vol. 21, no. 5, 634, 2016.
Digital.CSIC. Repositorio Institucional del CSIC
instname
Molecules, Vol 21, Iss 5, p 634 (2016)
Molecules
Molecules, vol. 21, no. 5, 634, 2016.
Digital.CSIC. Repositorio Institucional del CSIC
instname
Molecules, Vol 21, Iss 5, p 634 (2016)
Molecules
We report herein the straightforward two-step synthesis and biological assessment of novel racemic benzochromenopyrimidinones as non-hepatotoxic, acetylcholinesterase inhibitors with antioxidative properties. Among them, compound 3Bb displayed a mixe
Autor:
Lhassane Ismaili, Isabel Iriepa, Alexandre Bonet, Mourad Chioua, Manuela Bartolini, Houssem Boulebd, Ignacio Moraleda, Abdelmalek Bouraiou, Hélène Martin, José Marco-Contelles, Vincenza Andrisano, Ali Belfaitah
Publikováno v:
Molecules; Volume 21; Issue 4; Pages: 400
Molecules, Vol 21, Iss 4, p 400 (2016)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Molecules
Molecules, Vol 21, Iss 4, p 400 (2016)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Molecules
Herein we describe the synthesis and in vitro biological evaluation of thirteen new, racemic, diversely functionalized imidazo pyranotacrines as non-hepatotoxic, multipotent tacrine analogues. Among these compounds, 1-(5-amino-2-methyl-4-(1-methyl-1H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec3be0dd9203912c48896205e5018ad
http://hdl.handle.net/11585/550121
http://hdl.handle.net/11585/550121