Glutamine repeat variants in human RUNX2 associated with decreased femoral neck BMD, broadband ultrasound attenuation and target gene transactivation.

Autor: Nigel A Morrison, Alexandre A Stephens, Motomi Osato, Patsie Polly, Timothy C Tan, Namiko Yamashita, James D Doecke, Julie Pasco, Nicolette Fozzard, Graeme Jones, Stuart H Ralston, Philip N Sambrook, Richard L Prince, Geoff C Nicholson

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e42617 (2012)

RUNX2 is an essential transcription factor required for skeletal development and cartilage formation. Haploinsufficiency of RUNX2 leads to cleidocranial displaysia (CCD) a skeletal disorder characterised by gross dysgenesis of bones particularly thos

Externí odkaz: https://doaj.org/article/c0fe9df534154f1ca0d77b42ac84330d

Patterns of emergency department use in rural and metropolitan New South Wales by socioeconomic status: A population‐based study

Autor: Alexandre S Stephens, Michael M Dinh, Leigh Kinsman

Publikováno v: Emergency Medicine Australasia. 35:489-495

To investigate the patterns of ED use in metropolitan and rural New South Wales (NSW) by socioeconomic status (SES).We undertook a retrospective, population-based study of de-identified data from the NSW Emergency Department Data Collection (EDDC). T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a50d5cff5235b2c9edeefa5ab194254
https://doi.org/10.1111/1742-6723.14155

Patterns of emergency department use in rural and metropolitan New South Wales from 2012 to 2018

Autor: Alexandre S. Stephens, Julaine Allan, Andrew Bailey, Michael M Dinh, Leigh Kinsman, Alice Munro, John Wiggers, Alycia Jacob, Richard Cheney, Barbara Taylor, David Lyle, Tony Lower, Lauren Weller

Publikováno v: Australian Journal of Rural Health. 28:490-499

Objective To explore the patterns of and investigate the factors associated with rises in emergency department presentations in rural and metropolitan New South Wales from 2012 to 2018. Design A retrospective descriptive study of de-identified data f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266aa25ed8543e921999b43747f9668b
https://doi.org/10.1111/ajr.12668

'The ethics approval took 20 months on a trial which was meant to help terminally ill cancer patients. In the end we had to send the funding back':a survey of views on human research ethics reviews

Autor: Adrian G. Barnett, Simon Kolstoe, Iain Chalmers, Anna Mae Scott, Justin Clark, Alexandre S. Stephens, Paul Glasziou

Publikováno v: Scott, A M, Chalmers, I, Barnett, A, Stephens, A, Kolstoe, S E, Clark, J & Glasziou, P 2021, ' 'The ethics approval took 20 months on a trial which was meant to help terminally ill cancer patients. In the end we had to send the funding back' : a survey of views on human research ethics reviews ', Journal of Medical Ethics . https://doi.org/10.1136/medethics-2020-106785

BackgroundWe conducted a survey to identify what types of health/medical research could be exempt from research ethics reviews in Australia.MethodsWe surveyed Australian health/medical researchers and Human Research Ethics Committee (HREC) members. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ebb21c45b157eb3181d88827146107
https://researchportal.port.ac.uk/portal/en/publications/the-ethics-approval-took-20-months-on-a-trial-which-was-meant-to-help-terminally-ill-cancer-patients-in-the-end-we-had-to-send-the-funding-back(460cc22b-6600-449b-8d7b-9d69e41835b4).html

Polyalanine repeat polymorphism in RUNX2 is associated with site-specific fracture in post-menopausal females.

Autor: Nigel A Morrison, Alexandre S Stephens, Motomi Osato, Julie A Pasco, Nicolette Fozzard, Gary S Stein, Patsie Polly, Lyn R Griffiths, Geoff C Nicholson

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e72740 (2013)

Runt related transcription factor 2 (RUNX2) is a key regulator of osteoblast differentiation. Several variations within the RUNX2 gene have been found to be associated with significant changes in BMD, which is a major risk factor for fracture. In thi

Externí odkaz: https://doaj.org/article/4cb7fb85c59c4c0095fcf9eb7971b812