Zobrazeno 1 - 10
of 327
pro vyhledávání: '"Alexandre, Prat"'
Autor:
Sienna S. Drake, Aliyah Zaman, Christine Gianfelice, Elizabeth M.-L. Hua, Kali Heale, Elia Afanasiev, Wendy Klement, Jo Anne Stratton, Alexandre Prat, Stephanie Zandee, Alyson E. Fournier
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-18 (2024)
Abstract Background The role of senescence in disease contexts is complex, however there is considerable evidence that depletion of senescent cells improves outcomes in a variety of contexts particularly related to aging, cognition, and neurodegenera
Externí odkaz:
https://doaj.org/article/07e09c6af8784c0bbef1de4e6dc3cbe6
Autor:
Samantha F. Kornfeld, Sarah E. Cummings, Rebecca Yaworski, Yves De Repentigny, Sabrina Gagnon, Stephanie Zandee, Samaneh Fathi, Alexandre Prat, Rashmi Kothary
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-19 (2024)
Abstract Strategies for treating progressive multiple sclerosis (MS) remain limited. Here, we found that miR-145-5p is overabundant uniquely in chronic lesion tissues from secondary progressive MS patients. We induced both acute and chronic demyelina
Externí odkaz:
https://doaj.org/article/44c7ebcf25614e2aabf92ea59d7493d9
Autor:
Jiwon Oh, Nathalie Arbour, Fabrizio Giuliani, Melanie Guenette, Shannon Kolind, Larry Lynd, Ruth Ann Marrie, Luanne M. Metz, Alexandre Prat, Alice Schabas, Penelope Smyth, Roger Tam, Anthony Traboulsee, Voon Wee Yong, Scott B. Patten
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 17 (2024)
Background: Disease progression is observed across the spectrum of people with multiple sclerosis (MS) and identification of effective treatment strategies to halt progression remains one of the greatest unmet clinical needs. Objectives: The Canadian
Externí odkaz:
https://doaj.org/article/20a19b62873a48c5bfdb5748cc4d63f4
Autor:
Elsa Brunet-Ratnasingham, Sacha Morin, Haley E. Randolph, Marjorie Labrecque, Justin Bélair, Raphaël Lima-Barbosa, Amélie Pagliuzza, Lorie Marchitto, Michael Hultström, Julia Niessl, Rose Cloutier, Alina M. Sreng Flores, Nathalie Brassard, Mehdi Benlarbi, Jérémie Prévost, Shilei Ding, Sai Priya Anand, Gérémy Sannier, Amanda Marks, Dick Wågsäter, Eric Bareke, Hugo Zeberg, Miklos Lipcsey, Robert Frithiof, Anders Larsson, Sirui Zhou, Tomoko Nakanishi, David Morrison, Dani Vezina, Catherine Bourassa, Gabrielle Gendron-Lepage, Halima Medjahed, Floriane Point, Jonathan Richard, Catherine Larochelle, Alexandre Prat, Janet L. Cunningham, Nathalie Arbour, Madeleine Durand, J. Brent Richards, Kevin Moon, Nicolas Chomont, Andrés Finzi, Martine Tétreault, Luis Barreiro, Guy Wolf, Daniel E. Kaufmann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Plasma RNAemia, delayed antibody responses and inflammation predict COVID-19 outcomes, but the mechanisms underlying these immunovirological patterns are poorly understood. We profile 782 longitudinal plasma samples from 318 hospitalized pat
Externí odkaz:
https://doaj.org/article/59f2aa4758444b718331711ce163fcf7
Autor:
Nevin John, Steve Vucic, Riadh Gouider, Tomas Kalincik, Guillermo Izquierdo, Alexandre Prat, Marc Girard, Pierre Duquette, Pierre Grammond, Serkan Ozakbas, Jeannette Lechner-Scott, Cavit Boz, Julie Prevost, Recai Turkoglu, Vincent Van Pesch, Cristina Ramo-Tello, Mark Slee, Raed Alroughani, Vahid Shaygannejad, Daniele Spitaleri, José Luis Sánchez-Menoyo, Suzanne Hodgkinson, Rana Karabudak, Tim Spelman, Helmut Butzkueven, Noriko Isobe, Paul G Sanfilippo, Michael Barnett, Orla Gray, Maria José Sá, Allan Kermode, Guy Laureys, Richard Macdonell, Anneke Van Der Walt, Ayse Altintas, Mario Habek, Pamela McCombe, Seyed Mohammad Baghbanian, Yi Chao Foong, Riki Matsumoto, Abdullah Al-Asmi, Bruce Taylor, Samia J Khoury, Todd Hardy, Katherine Buzzard, Marzena Fabis-Pedrini, Louise Rath, Olga Skibina, Jiwon Oh, William M Carroll, Katrin Gross-Paju, Jan Schepel, Sara Eichau, Elisabetta Cartechini, Aysun Soysal, Davide Maimone, Anoushka Lal, Masoud Etemadifar, Oliver Gerlach, Saloua Mrabet, Emanuele D'Amico, Yolanda Blanco, Matteo Foschi, Melissa Cambron, Andrea Surcinelli, David Levitz, Liesbeth Van Hijfte, Mehmet Fatih Yetkin, Simón Cárdenas-Robledo, Emmanuelle Lapointe, Abdorreza Naser Moghadasi, Gregor Brecl Jakob, Talal Al-Harbi
Publikováno v:
BMJ Neurology Open, Vol 6, Iss Suppl 1 (2024)
Externí odkaz:
https://doaj.org/article/fc8e0655ceeb42e4b6966e9c79930d0b
Autor:
Edward De Brouwer, Thijs Becker, Lorin Werthen-Brabants, Pieter Dewulf, Dimitrios Iliadis, Cathérine Dekeyser, Guy Laureys, Bart Van Wijmeersch, Veronica Popescu, Tom Dhaene, Dirk Deschrijver, Willem Waegeman, Bernard De Baets, Michiel Stock, Dana Horakova, Francesco Patti, Guillermo Izquierdo, Sara Eichau, Marc Girard, Alexandre Prat, Alessandra Lugaresi, Pierre Grammond, Tomas Kalincik, Raed Alroughani, Francois Grand'Maison, Olga Skibina, Murat Terzi, Jeannette Lechner-Scott, Oliver Gerlach, Samia J Khoury, Elisabetta Cartechini, Vincent Van Pesch, Maria José Sà, Bianca Weinstock-Guttman, Yolanda Blanco, Radek Ampapa, Daniele Spitaleri, Claudio Solaro, Davide Maimone, Aysun Soysal, Gerardo Iuliano, Riadh Gouider, Tamara Castillo-Triviño, José Luis Sánchez-Menoyo, Anneke van der Walt, Jiwon Oh, Eduardo Aguera-Morales, Ayse Altintas, Abdullah Al-Asmi, Koen de Gans, Yara Fragoso, Tunde Csepany, Suzanne Hodgkinson, Norma Deri, Talal Al-Harbi, Bruce Taylor, Orla Gray, Patrice Lalive, Csilla Rozsa, Chris McGuigan, Allan Kermode, Angel Pérez Sempere, Simu Mihaela, Magdolna Simo, Todd Hardy, Danny Decoo, Stella Hughes, Nikolaos Grigoriadis, Attila Sas, Norbert Vella, Yves Moreau, Liesbet Peeters
Publikováno v:
PLOS Digital Health, Vol 3, Iss 7, p e0000533 (2024)
BackgroundDisability progression is a key milestone in the disease evolution of people with multiple sclerosis (PwMS). Prediction models of the probability of disability progression have not yet reached the level of trust needed to be adopted in the
Externí odkaz:
https://doaj.org/article/c8086e53dc844308be0ea446e3a32319
Autor:
Amel Zertal, Kanza Alami Marrouni, Nathalie Arbour, Didier Jutras-Aswad, Marie-Pascale Pomey, Isabelle Rouleau, Alexandre Prat, Catherine Larochelle, Pierre Beaulieu, Laury Chamelian, Marie-Pierre Sylvestre, Danielle Morin, Jean-Sylvain Ouellette, Nathalie Fréjeau, Pierre Duquette
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
BackgroundMultiple sclerosis (MS) is an inflammatory and degenerative disease of the central nervous system. More than 90,000 Canadians are affected; a cure is yet to be found. Available treatments to manage the disease course are only partially effe
Externí odkaz:
https://doaj.org/article/c556e8cf34584805a9ee8cb8883f7369
Autor:
Florian Pernin, Qiao-Ling Cui, Abdulshakour Mohammadnia, Milton G. F. Fernandes, Jeffery A. Hall, Myriam Srour, Roy W. R. Dudley, Stephanie E. J. Zandee, Wendy Klement, Alexandre Prat, Hannah E. Salapa, Michael C. Levin, G. R. Wayne Moore, Timothy E. Kennedy, Christine Vande Velde, Jack P. Antel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Oligodendrocyte (OL) injury and subsequent loss is a pathologic hallmark of multiple sclerosis (MS). Stress granules (SGs) are membrane-less organelles containing mRNAs stalled in translation and considered as participants of the cellular re
Externí odkaz:
https://doaj.org/article/7ecd4f332096485d86164c4aeb9e24fc
Autor:
Priya Jhelum, Stephanie Zandee, Fari Ryan, Juan G. Zarruk, Bernhard Michalke, Vivek Venkataramani, Laura Curran, Wendy Klement, Alexandre Prat, Samuel David
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-22 (2023)
Abstract Ferroptosis is a form of lipid peroxidation-mediated cell death and damage triggered by excess iron and insufficiency in the glutathione antioxidant pathway. Oxidative stress is thought to play a crucial role in progressive forms of multiple
Externí odkaz:
https://doaj.org/article/18aee7bd8ba0455cb2561b0275634eaa
Autor:
Milton Guilherme Forestieri Fernandes, Abdulshakour Mohammadnia, Florian Pernin, Laura Eleonora Schmitz-Gielsdorf, Caroline Hodgins, Qiao-Ling Cui, Moein Yaqubi, Manon Blain, Jeffery Hall, Roy Dudley, Myriam Srour, Stephanie E. J. Zandee, Wendy Klement, Alexandre Prat, Jo Anne Stratton, Moses Rodriguez, Tanja Kuhlmann, Wayne Moore, Timothy E. Kennedy, Jack P. Antel
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-16 (2023)
Abstract Oligodendrocyte (OL) injury and loss are central features of evolving lesions in multiple sclerosis. Potential causative mechanisms of OL loss include metabolic stress within the lesion microenvironment. Here we use the injury response of pr
Externí odkaz:
https://doaj.org/article/0b83309164e245e4aea64f44e59886dc