Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Alexandre, Pawlik"'
Autor:
Camille Sous, Wafa Frigui, Alexandre Pawlik, Fadel Sayes, Laurence Ma, Thomas Cokelaer, Roland Brosch
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 6 (2024)
ABSTRACT Four species of non-tuberculous mycobacteria (NTM) rated as biosafety level 1 or 2 (BSL-1/BSL-2) organisms and showing higher genomic similarity with Mycobacterium tuberculosis (Mtb) than previous comparator species Mycobacterium kansasii an
Externí odkaz:
https://doaj.org/article/ba98bcfd71dc497e9da14c0fddcb9a9d
Autor:
Alexandra Maure, Emeline Lawarée, Francesco Fiorentino, Alexandre Pawlik, Saideep Gona, Alexandre Giraud-Gatineau, Matthew J G Eldridge, Anne Danckaert, David Hardy, Wafa Frigui, Camille Keck, Claude Gutierrez, Olivier Neyrolles, Nathalie Aulner, Antonello Mai, Mélanie Hamon, Luis B Barreiro, Priscille Brodin, Roland Brosch, Dante Rotili, Ludovic Tailleux
Publikováno v:
PLoS Biology, Vol 22, Iss 4, p e3002259 (2024)
Antituberculosis drugs, mostly developed over 60 years ago, combined with a poorly effective vaccine, have failed to eradicate tuberculosis. More worryingly, multiresistant strains of Mycobacterium tuberculosis (MTB) are constantly emerging. Innovati
Externí odkaz:
https://doaj.org/article/e2eedf80218b48f79d34efc207ddd2fb
Autor:
Jodie Lopez, François Anna, Pierre Authié, Alexandre Pawlik, Min-Wen Ku, Catherine Blanc, Philippe Souque, Fanny Moncoq, Amandine Noirat, David Hardy, Wladimir Sougakoff, Roland Brosch, Françoise Guinet, Pierre Charneau, Laleh Majlessi
Publikováno v:
Cell Reports, Vol 40, Iss 4, Pp 111142- (2022)
Summary: Lentiviral vectors (LVs) are highly efficient at inducing CD8+ T cell responses. However, LV-encoded antigens are processed inside the cytosol of antigen-presenting cells, which does not directly communicate with the endosomal major histocom
Externí odkaz:
https://doaj.org/article/464bede2d4844e65b8993381d9865e5e
Autor:
Daria Bottai, Wafa Frigui, Fadel Sayes, Mariagrazia Di Luca, Dalila Spadoni, Alexandre Pawlik, Marina Zoppo, Mickael Orgeur, Varun Khanna, David Hardy, Sophie Mangenot, Valerie Barbe, Claudine Medigue, Laurence Ma, Christiane Bouchier, Arianna Tavanti, Gerald Larrouy-Maumus, Roland Brosch
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Mycobacterium tuberculosis (Mtb) modern strains emerged from a common progenitor after the loss of Mtb-specific deletion 1 region (TbD1). Here, the authors show that deletion of TbD1 correlates with enhanced Mtb virulence in animal models, mirroring
Externí odkaz:
https://doaj.org/article/dfe06d57f9b145fda733b5868dbc18ce
Autor:
Thomas Laval, Laura Pedró-Cos, Wladimir Malaga, Laure Guenin-Macé, Alexandre Pawlik, Véronique Mayau, Hanane Yahia-Cherbal, Océane Delos, Wafa Frigui, Justine Bertrand-Michel, Christophe Guilhot, Caroline Demangel
Publikováno v:
eLife, Vol 10 (2021)
Successful control of Mycobacterium tuberculosis (Mtb) infection by macrophages relies on immunometabolic reprogramming, where the role of fatty acids (FAs) remains poorly understood. Recent studies unraveled Mtb’s capacity to acquire saturated and
Externí odkaz:
https://doaj.org/article/6c326e6d166f4e94a777416a85426868
Autor:
François Anna, Jodie Lopez, Fanny Moncoq, Catherine Blanc, Pierre Authié, Amandine Noirat, Ingrid Fert, Philippe Souque, Fabien Nevo, Alexandre Pawlik, David Hardy, Sophie Goyard, Denis Hudrisier, Roland Brosch, Françoise Guinet, Olivier Neyrolles, Pierre Charneau, Laleh Majlessi
Publikováno v:
Mucosal Immunology
Mucosal Immunology, 2022, 15 (6), pp.1389-1404. ⟨10.1038/s41385-022-00566-z⟩
Mucosal Immunology, 2022, 15 (6), pp.1389-1404. ⟨10.1038/s41385-022-00566-z⟩
International audience; Abstract Most viral vectors, including the potently immunogenic lentiviral vectors (LVs), only poorly direct antigens to the MHC-II endosomal pathway and elicit CD4 + T cells. We developed a new generation of LVs encoding anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b652041ced51b00d963f1d56cb1756f7
https://doi.org/10.1038/s41385-022-00566-z
https://doi.org/10.1038/s41385-022-00566-z
Autor:
Matthias I. Gröschel, Fadel Sayes, Sung Jae Shin, Wafa Frigui, Alexandre Pawlik, Mickael Orgeur, Robin Canetti, Nadine Honoré, Roxane Simeone, Tjip S. van der Werf, Wilbert Bitter, Sang-Nae Cho, Laleh Majlessi, Roland Brosch
Publikováno v:
Cell Reports, Vol 18, Iss 11, Pp 2752-2765 (2017)
Recent insights into the mechanisms by which Mycobacterium tuberculosis, the etiologic agent of human tuberculosis, is recognized by cytosolic nucleotide sensors have opened new avenues for rational vaccine design. The only licensed anti-tuberculosis
Externí odkaz:
https://doaj.org/article/f660fea52b284bd7b246a1bd2718692d
Autor:
Violaine Dubois, Alexandre Pawlik, Anouchka Bories, Vincent Le Moigne, Odile Sismeiro, Rachel Legendre, Hugo Varet, María Del Pilar Rodríguez-Ordóñez, Jean-Louis Gaillard, Jean-Yves Coppée, Roland Brosch, Jean-Louis Herrmann, Fabienne Girard-Misguich
Publikováno v:
PLoS Pathogens, Vol 15, Iss 11, p e1008069 (2019)
Free-living amoebae are thought to represent an environmental niche in which amoeba-resistant bacteria may evolve towards pathogenicity. To get more insights into factors playing a role for adaptation to intracellular life, we characterized the trans
Externí odkaz:
https://doaj.org/article/86993c1613b349b08595a5ccf2baa572
Autor:
Vincent Le Moigne, Audrey Bernut, Mélanie Cortès, Albertus Viljoen, Christian Dupont, Alexandre Pawlik, Jean-Louis Gaillard, Fabienne Misguich, Frédéric Crémazy, Laurent Kremer, Jean-Louis Herrmann
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Mycobacterium abscessus, a pathogen responsible for severe lung infections in cystic fibrosis patients, exhibits either smooth (S) or rough (R) morphotypes. The S-to-R transition correlates with inhibition of the synthesis and/or transport of glycope
Externí odkaz:
https://doaj.org/article/37c589bad729462bb2429f19f7fe7a9e
Autor:
Fadel Sayes, Alexandre Pawlik, Wafa Frigui, Matthias I Gröschel, Samuel Crommelynck, Catherine Fayolle, Felipe Cia, Gregory J Bancroft, Daria Bottai, Claude Leclerc, Roland Brosch, Laleh Majlessi
Publikováno v:
PLoS Pathogens, Vol 12, Iss 7, p e1005770 (2016)
Mycobacterium tuberculosis (Mtb), possesses at least three type VII secretion systems, ESX-1, -3 and -5 that are actively involved in pathogenesis and host-pathogen interaction. We recently showed that an attenuated Mtb vaccine candidate (Mtb Δppe25
Externí odkaz:
https://doaj.org/article/d8ad9bcf1937474182e449b1af1359d0