Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Alexandre, Orthwein"'
Autor:
Talin Ebrahimian, France Dierick, Vincent Ta, Maria Kotsiopriftis, Jonathan O’Connor Miranda, Koren K. Mann, Alexandre Orthwein, Stephanie Lehoux
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Antigen-naive IgM-producing B cells are atheroprotective, whereas mature B cells producing class-switched antibodies promote atherosclerosis. Activation-induced cytidine deaminase (AID), which mediates class switch recombination (CSR), would
Externí odkaz:
https://doaj.org/article/46c5d8ed292f491ba4c713375be2a4b3
Autor:
Katie Fooks, Gabriela Galicia-Vazquez, Victor Gife, Alejandro Schcolnik-Cabrera, Zaynab Nouhi, William W. L. Poon, Vincent Luo, Ryan N. Rys, Raquel Aloyz, Alexandre Orthwein, Nathalie A. Johnson, Laura Hulea, Francois E. Mercier
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-19 (2022)
Abstract Background Acute myeloid leukemia (AML) is an aggressive hematological cancer resulting from uncontrolled proliferation of differentiation-blocked myeloid cells. Seventy percent of AML patients are currently not cured with available treatmen
Externí odkaz:
https://doaj.org/article/e6bb8583447d4acda27cf156d9e76eb8
Autor:
Estelle Simo Cheyou, Jacopo Boni, Jonathan Boulais, Edgar Pinedo-Carpio, Abba Malina, Dana Sherill-Rofe, Vincent M Luo, Christophe Goncalves, Halil Bagci, Alexandra Maters, Raquel Cuella-Martin, Yuval Tabach, Sonia Del Rincon, Jean-Francois Côté, Barbara Rivera, Alexandre Orthwein
Publikováno v:
PLoS Genetics, Vol 18, Iss 11, p e1010495 (2022)
Homologous recombination (HR) plays an essential role in the maintenance of genome stability by promoting the repair of cytotoxic DNA double strand breaks (DSBs). More recently, the HR pathway has emerged as a core component of the response to replic
Externí odkaz:
https://doaj.org/article/4cdde5847f534e37a95404622965275b
Autor:
Thibaut S. Matis, Nadia Zayed, Bouchra Labraki, Manon de Ladurantaye, Théophane A. Matis, José Camacho Valenzuela, Nancy Hamel, Adrienne Atayan, Barbara Rivera, Yuval Tabach, Patricia N. Tonin, Alexandre Orthwein, Anne-Marie Mes-Masson, Zaki El Haffaf, William D. Foulkes, Paz Polak
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-7 (2021)
Abstract It was hypothesized that variants in underexplored homologous recombination repair (HR) genes could explain unsolved multiple-case breast cancer (BC) families. We investigated HR deficiency (HRD)-associated mutational signatures and second h
Externí odkaz:
https://doaj.org/article/cbb6acef8a0543f6b4e46805a7d21ec0
Autor:
Charles Vadnais, Riyan Chen, Jennifer Fraszczak, Zhenbao Yu, Jonathan Boulais, Jordan Pinder, Daria Frank, Cyrus Khandanpour, Josée Hébert, Graham Dellaire, Jean-François Côté, Stéphane Richard, Alexandre Orthwein, Elliot Drobetsky, Tarik Möröy
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The transcription factor GFI1 mediates the DNA damage response (DDR) of T cells through a yet unknown mechanism. Here the authors show that GFI1 can adopt non-transcriptional roles during DDR, enabling PRMT1 to bind and methylate the DNA repair prote
Externí odkaz:
https://doaj.org/article/84219a0ff4704d3586e8769eac7e762a
Autor:
William D. Foulkes, Alexandre Orthwein, Patricia N. Tonin, Christopher J. Lord, Mohammad R. Akbari, Steven A. Narod, Reiner Siebert, Susanne Bens, Jacek Majewski, Anne-Marie Mes-Masson, Jacques L. Michaud, Guy A. Rouleau, Diane Provencher, Albert M. Berghuis, Francois Rousseau, George Zogopoulos, Alexandre Dionne-Laporte, Fadi F. Hamdan, Sylvie Giroux, Olga Aleynikova, Rabea Wagener, Nancy Hamel, Valerie Hastings, Eva Tomiak, Damien Grapton, David L. Burk, Suzanna L. Arcand, Somayyeh Fahiminiya, Javad Nadaf, Jessica Frankum, Massimo Di Iorio, Barbara Rivera
'Supplementary Table S2- Somatic mutations identified in the tumors from individuals III.6; III.7 and III.8 in family 1 and individual III.1 in family 2 among 193 DNA repair genes.'
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369000d8c9d62bb2c1e36e02e21dc78f
https://doi.org/10.1158/0008-5472.22414869.v1
https://doi.org/10.1158/0008-5472.22414869.v1
Autor:
William D. Foulkes, Alexandre Orthwein, Patricia N. Tonin, Christopher J. Lord, Mohammad R. Akbari, Steven A. Narod, Reiner Siebert, Susanne Bens, Jacek Majewski, Anne-Marie Mes-Masson, Jacques L. Michaud, Guy A. Rouleau, Diane Provencher, Albert M. Berghuis, Francois Rousseau, George Zogopoulos, Alexandre Dionne-Laporte, Fadi F. Hamdan, Sylvie Giroux, Olga Aleynikova, Rabea Wagener, Nancy Hamel, Valerie Hastings, Eva Tomiak, Damien Grapton, David L. Burk, Suzanna L. Arcand, Somayyeh Fahiminiya, Javad Nadaf, Jessica Frankum, Massimo Di Iorio, Barbara Rivera
This file includes supplementary Figure S1, Supplementary Figure S2 and Supplementary Figure S3. It also includes Supplementary Table S1 - RAD51D c.620C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71788fdaf41387d0575150ff4e63b88d
https://doi.org/10.1158/0008-5472.22414863.v1
https://doi.org/10.1158/0008-5472.22414863.v1
Autor:
William D. Foulkes, Alexandre Orthwein, Patricia N. Tonin, Christopher J. Lord, Mohammad R. Akbari, Steven A. Narod, Reiner Siebert, Susanne Bens, Jacek Majewski, Anne-Marie Mes-Masson, Jacques L. Michaud, Guy A. Rouleau, Diane Provencher, Albert M. Berghuis, Francois Rousseau, George Zogopoulos, Alexandre Dionne-Laporte, Fadi F. Hamdan, Sylvie Giroux, Olga Aleynikova, Rabea Wagener, Nancy Hamel, Valerie Hastings, Eva Tomiak, Damien Grapton, David L. Burk, Suzanna L. Arcand, Somayyeh Fahiminiya, Javad Nadaf, Jessica Frankum, Massimo Di Iorio, Barbara Rivera
'Supplementary Table3 -Presence of allelic imbalanced alleles in RAD51D and TP53 somatic mutations in RAD51D c.620C>T;p.S207L HGSC carriers.'
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e0bafeeb6dd8be89a2dc3acd1a2ee99
https://doi.org/10.1158/0008-5472.22414866
https://doi.org/10.1158/0008-5472.22414866
Autor:
William D. Foulkes, Alexandre Orthwein, Patricia N. Tonin, Christopher J. Lord, Mohammad R. Akbari, Steven A. Narod, Reiner Siebert, Susanne Bens, Jacek Majewski, Anne-Marie Mes-Masson, Jacques L. Michaud, Guy A. Rouleau, Diane Provencher, Albert M. Berghuis, Francois Rousseau, George Zogopoulos, Alexandre Dionne-Laporte, Fadi F. Hamdan, Sylvie Giroux, Olga Aleynikova, Rabea Wagener, Nancy Hamel, Valerie Hastings, Eva Tomiak, Damien Grapton, David L. Burk, Suzanna L. Arcand, Somayyeh Fahiminiya, Javad Nadaf, Jessica Frankum, Massimo Di Iorio, Barbara Rivera
RAD51D is a key player in DNA repair by homologous recombination (HR), and RAD51D truncating variant carriers have an increased risk for ovarian cancer. However, the contribution of nontruncating RAD51D variants to cancer predisposition remains uncer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7c1fda50beb24af86d523282dd71f2c
https://doi.org/10.1158/0008-5472.c.6509097.v1
https://doi.org/10.1158/0008-5472.c.6509097.v1
Autor:
Steven Findlay, Remya Nair, Ronald A Merrill, Zafir Kaiser, Alexandre Cajelot, Zahra Aryanpour, John Heath, Catherine St-Louis, David Papadopoli, Ivan Topisirovic, Julie St-Pierre, Michael Sebag, Aparna H Kesarwala, Laura Hulea, Eric B Taylor, Mala Shanmugam, Alexandre Orthwein
Publikováno v:
Blood Advances.
Multiple myeloma (MM) is a hematological malignancy that emerges from antibody-producing plasma B cells. Proteasome inhibitors, including the FDA-approved bortezomib (BTZ) and carfilzomib (CFZ), are frequently used for the treatment of MM patients. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92ee2781719047fd98f2fe44115ad74b
https://doi.org/10.1182/bloodadvances.2022008345
https://doi.org/10.1182/bloodadvances.2022008345