Binding of RNA by the Nucleoproteins of Influenza Viruses A and B

Autor: Alice Labaronne, Christopher Swale, Alexandre Monod, Guy Schoehn, Thibaut Crépin, Rob W. H. Ruigrok

Publikováno v: Viruses, Vol 8, Iss 9, p 247 (2016)

This paper describes a biochemical study for making complexes between the nucleoprotein of influenza viruses A and B (A/NP and B/NP) and small RNAs (polyUC RNAs from 5 to 24 nucleotides (nt)), starting from monomeric proteins. We used negative stain

Externí odkaz: https://doaj.org/article/66779fc6938342a99f5f5ce7588a206e

Structural characterization of recombinant IAV polymerase reveals a stable complex between viral PA-PB1 heterodimer and host RanBP5

Autor: Alice Labaronne, Christopher Swale, Imre Berger, Laura Tengo, Thibaut Crépin, Rob W. H. Ruigrok, Alexandre Monod, Frederic Garzoni, Stephen Cusack, Jean-Marie Bourhis, Guy Schoehn

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2016, 6, pp.24727. ⟨10.1038/srep24727⟩
Swale, C, Monod, A, Tengo, L, Labaronne, A, Garzoni, F, Bourhis, J-M, Cusack, S, Schoehn, G, Berger, I, Ruigrok, R W H & Crépin, T 2016, ' Structural characterization of recombinant IAV polymerase reveals a stable complex between viral PA-PB1 heterodimer and host RanBP5 ', Scientific Reports, vol. 6, 24727 . https://doi.org/10.1038/srep24727
'Scientific Reports ', vol: 6, pages: 24727-1-24727-14 (2016)
Scientific Reports, 2016, 6, pp.24727. ⟨10.1038/srep24727⟩

The genome of influenza A virus (IAV) comprises eight RNA segments (vRNA) which are transcribed and replicated by the heterotrimeric IAV RNA-dependent RNA-polymerase (RdRp). RdRp consists of three subunits (PA, PB1 and PB2) and binds both the highly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2deeb85a14a28bd835a77f7c7547fd5
http://europepmc.org/articles/PMC4837377

In Vitro/In Vivo Production of tRNA for X-Ray Studies

Autor: Thibaut Crépin, Franck Brachet, Carine Tisné, Clément Dégut, Alexandre Monod

Publikováno v: Methods in Molecular Biology ISBN: 9781493927623

tRNAs occupy a central role in the cellular life, and they are involved in a broad range of biological processes that relies on their interaction with proteins and RNA. Crystallization and structure resolution of tRNA or/and tRNA/partner complexes ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::896856a8f8226bc8c94010a19f6760dc
https://doi.org/10.1007/978-1-4939-2763-0_4

Learning from structure-based drug design and new antivirals targeting the ribonucleoprotein complex for the treatment of influenza

Autor: Rob W. H. Ruigrok, Alexandre Monod, Bogdan Tarus, Thibaut Crépin, Christopher Swale, Alice Tissot, Anny Slama-Schwok, Bernard Delmas

Publikováno v: Expert Opinion on Drug Discovery
Expert Opinion on Drug Discovery, Informa Healthcare, 2015, 10 (4), pp.345-371. ⟨10.1517/17460441.2015.1019859⟩
Expert Opinion on Drug Discovery, Informa Healthcare, 2015, 10 (4), pp.345-71

International audience; Introduction: Influenza viruses are a threat to human health. There are presently only two methods for treating influenza: vaccines, which require yearly updates, and two classes of antivirals that suffer with the problem of r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e50d65bd2b7c0c7d5bb5dccbd2495e
https://hal.inrae.fr/hal-02639384