Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Alexandre, Maréchal"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract As modern agricultural practices increase their use of chemical pesticides, it is inevitable that we will find a number of these xenobiotics within drinking water supplies and disseminated throughout the food chain. A major problem that aris
Externí odkaz:
https://doaj.org/article/80bc2c743dc743c9846083b84b78a27b
Autor:
Maïlyn Yates, Isabelle Marois, Edlie St-Hilaire, Daryl A Ronato, Billel Djerir, Chloé Brochu, Théo Morin, Ian Hammond-Martel, Sari Gezzar-Dandashi, Lisa Casimir, Elliot Drobetsky, Laurent Cappadocia, Jean-Yves Masson, Hugo Wurtele, Alexandre Maréchal
Publikováno v:
PLoS Biology, Vol 22, Iss 3, p e3002552 (2024)
Impediments in replication fork progression cause genomic instability, mutagenesis, and severe pathologies. At stalled forks, RPA-coated single-stranded DNA (ssDNA) activates the ATR kinase and directs fork remodeling, 2 key early events of the repli
Externí odkaz:
https://doaj.org/article/7a96143210c043db9c56e93cd5ee4106
Publikováno v:
Cell Reports, Vol 14, Iss 5, Pp 1032-1040 (2016)
Summary: Cancer cells overcome replicative senescence by exploiting mechanisms of telomere elongation, a process often accomplished by reactivation of the enzyme telomerase. However, a subset of cancer cells lack telomerase activity and rely on the a
Externí odkaz:
https://doaj.org/article/6d1d338720ea455ca950a841a7b295bf
Autor:
Elise Vickridge, Camila C F Faraco, Payman S Tehrani, Zubaidah M Ramdzan, Billel Djerir, Hedyeh Rahimian, Lam Leduy, Alexandre Maréchal, Anne-Claude Gingras, Alain Nepveu
Publikováno v:
NAR Cancer. 4
We identified the BCL11A protein in a proximity-dependent biotinylation screen performed with the DNA glycosylase NTHL1. In vitro, DNA repair assays demonstrate that both BCL11A and a small recombinant BCL11A160–520 protein that is devoid of DNA bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc96c1e14b663c9c8718f2723cde893
https://doi.org/10.1093/narcan/zcac028
https://doi.org/10.1093/narcan/zcac028
Autor:
Bunsyo Shiotani, Hai Dang Nguyen, Pelle Håkansson, Alexandre Maréchal, Alice Tse, Hidetoshi Tahara, Lee Zou
Publikováno v:
Cell Reports, Vol 3, Iss 5, Pp 1651-1662 (2013)
The ATM- and Rad3-related (ATR) kinase is a master regulator of the DNA damage response, yet how ATR is activated toward different substrates is still poorly understood. Here, we show that ATR phosphorylates Chk1 and RPA32 through distinct mechanisms
Externí odkaz:
https://doaj.org/article/78a61f8549a041a6b7a3a75c64981561
Autor:
Lisa, Casimir, Samuel, Zimmer, Félix, Racine-Brassard, Pierre-Étienne, Jacques, Alexandre, Maréchal
Publikováno v:
DNA Repair. 122:103433
Illudin S (ILS) is a fungal sesquiterpene secondary metabolite with potent genotoxic and cytotoxic properties. Early genetic studies and more recent genome-wide CRISPR screens showed that Illudin-induced lesions are preferentially repaired by transcr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db79c833509d7cf40227b9765d8e23d
https://doi.org/10.1016/j.dnarep.2022.103433
https://doi.org/10.1016/j.dnarep.2022.103433
Autor:
Mouhamed Idrissou, Alexandre Maréchal
Publikováno v:
Cancers. 14(4)
mRNA processing factors are increasingly being recognized as important regulators of genome stability. By preventing and resolving RNA:DNA hybrids that form co-transcriptionally, these proteins help avoid replication–transcription conflicts and thu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fac8d7eede996f560ef9be3c653cabc
https://pubmed.ncbi.nlm.nih.gov/35205626
https://pubmed.ncbi.nlm.nih.gov/35205626
Autor:
Josie Ursini-Siegel, Steven Findlay, Jeesan Lee, Jean-François Côté, Alexandre Orthwein, Alexandre Maréchal, Martin Karam, Edgar Pinedo Carpio, Stéphane Richard, Benjamin Lebeau, Vincent M Luo, Billel Djerir, Damien Grapton, Xiaoru Chen, Estelle Simo Cheyou, Halil Bagci, John K. Heath, Michael Witcher, Théo Morin
Publikováno v:
EMBO Rep
The heterochromatin protein HP1 plays a central role in the maintenance of genome stability but little is known about how HP1 is controlled. Here, we show that the zinc finger protein POGZ promotes the presence of HP1 at DNA double‐strand breaks (D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a2ceae26b097e5b7517fd8925bb21b
https://europepmc.org/articles/PMC8728601/
https://europepmc.org/articles/PMC8728601/
Autor:
Estelle Simo Cheyou, Benjamin Lebeau, Alexandre Maréchal, Michael Witcher, Steven Findlay, Damien Grapton, Halil Bagci, Josie Ursini-Siegel, Stéphane Richard, Carpio Ep, Chen X, Lee J, John K. Heath, Théo Morin, Billel Djerir, Vincent M Luo, Alexandre Orthwein, Jean-François Côté, Martin Karam
The heterochromatin protein HP1 plays a central role in the maintenance of genome stability, in particular by promoting homologous recombination (HR)-mediated DNA repair. However, little is still known about how HP1 is controlled during this process.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32d10bce464aa5d97319a47855d5965d
https://doi.org/10.1101/2021.06.28.447216
https://doi.org/10.1101/2021.06.28.447216
Autor:
Alain Nepveu, Elise Vickridge, Zubaidah M. Ramdzan, Billel Djerir, Lam Leduy, Camila C.F. Faraco, Li Li, Alexandre Maréchal
Publikováno v:
Journal of molecular biology. 433(4)
The full-length CUX1 protein isoform was previously shown to function as an auxiliary factor in base excision repair (BER). Specifically, CUT domains within CUX1 stimulate the enzymatic activities of the OGG1 DNA glycosylase and APE1 endonuclease. Mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f911941b90bc35df138f9c78a6b35d74
https://pubmed.ncbi.nlm.nih.gov/33450246
https://pubmed.ncbi.nlm.nih.gov/33450246