Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Alexandre, Dubrac"'
Autor:
Yassine El Bakkouri, Rony Chidiac, Chantal Delisle, Jeanne Corriveau, Gael Cagnone, Vanda Gaonac’h-Lovejoy, Ashley Chin, Éric Lécuyer, Stephane Angers, Jean-Sébastien Joyal, Ivan Topisirovic, Laura Hulea, Alexandre Dubrac, Jean-Philippe Gratton
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Zonula occludens-1 (ZO-1) is involved in the regulation of cell-cell junctions between endothelial cells (ECs). Here we identify the ZO-1 protein interactome and uncover ZO-1 interactions with RNA-binding proteins that are part of stress gra
Externí odkaz:
https://doaj.org/article/95ff214a0fa9446fbd3a459e08308533
Autor:
Xinyu Gu, Xun Chen, Xuan Zhang, Keli Liu, Jing-Jing Li, Wenyu Lv, Lei Zeng, Mingjuan Wu, Weibin Zhou, Weifa Wang, Shunhua Shi, Yicheng Deng, Yunhua Li, Xinbo Gao, Rong Ju, Alexandre Dubrac, Xialin Liu, Feng Zhang
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113799- (2024)
Summary: Schlemm’s canal (SC) functions to maintain proper intraocular pressure (IOP) by draining aqueous humor and has emerged as a promising therapeutic target for glaucoma, the second-leading cause of irreversible blindness worldwide. However, o
Externí odkaz:
https://doaj.org/article/edbae61332d34f9c8f8bc204615614a1
Publikováno v:
Frontiers in Human Neuroscience, Vol 16 (2022)
Hereditary hemorrhagic telangiectasia (HHT) is a genetic disorder characterized by vessel dilatation, such as telangiectasia in skin and mucosa and arteriovenous malformations (AVM) in internal organs such as the gastrointestinal tract, lungs, and br
Externí odkaz:
https://doaj.org/article/daf53121735d40ecb7747a11e28c62bb
Autor:
Gael Genet, Kevin Boyé, Thomas Mathivet, Roxana Ola, Feng Zhang, Alexandre Dubrac, Jinyu Li, Nafiisha Genet, Luiz Henrique Geraldo, Lorena Benedetti, Steffen Künzel, Laurence Pibouin-Fragner, Jean-Leon Thomas, Anne Eichmann
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
VEGF-A/VEGFR2 signaling is a key driver of endothelial cell migration during sprouting angiogenesis. Here Genet et al. show that endophilin A2 regulates these processes by mediating clathrin-independent VEGFR2 internalization.
Externí odkaz:
https://doaj.org/article/a65242a5aee94d9999a57269b93f9bd4
Autor:
Alexandre Dubrac, Steffen E. Künzel, Sandrine H. Künzel, Jinyu Li, Rachana Radhamani Chandran, Kathleen Martin, Daniel M. Greif, Ralf H. Adams, Anne Eichmann
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Pericytes are perivascular cells that regulate blood vessel formation and function. Here Dubrac et al. show that pericyte recruitment contributes to pathological neovascularisation in a mouse model of ischemic retinopathy, and that this depends on th
Externí odkaz:
https://doaj.org/article/f212c5aa389b4f57a14e393ebd8caa17
Autor:
Zeitz, Steffen E. Künzel, Leonie T. M. Flesch, Dominik P. Frentzel, Vitus A. Knecht, Anne Rübsam, Felix Dreher, Moritz Schütte, Alexandre Dubrac, Bodo Lange, Marie-Laure Yaspo, Hans Lehrach, Antonia M. Joussen, Oliver
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 12; Pages: 10327
There is early evidence of extraocular systemic signals effecting function and morphology in neovascular age-related macular degeneration (nAMD). The prospective, cross-sectional BIOMAC study is an explorative investigation of peripheral blood proteo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::6684b786242ec29971e67f68cd9915fa
Autor:
Roxana Ola, Alexandre Dubrac, Jinah Han, Feng Zhang, Jennifer S. Fang, Bruno Larrivée, Monica Lee, Ana A. Urarte, Jan R. Kraehling, Gael Genet, Karen K. Hirschi, William C. Sessa, Francesc V. Canals, Mariona Graupera, Minhong Yan, Lawrence H. Young, Paul S. Oh, Anne Eichmann
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Arteriovenous malformations (AVM) is a hallmark of hereditary haemorrhagic telangiectasia type 2, a disease caused by mutations in BMP receptor ALK1. Ola et al. show that AVM can be caused by blocking BMP9 and BMP10 in mice, leading to increased VEGF
Externí odkaz:
https://doaj.org/article/7b411bab54424730b576b6b6c001bd4f
Autor:
Feng Zhang, Claudia Prahst, Thomas Mathivet, Laurence Pibouin-Fragner, Jiasheng Zhang, Gael Genet, Raymond Tong, Alexandre Dubrac, Anne Eichmann
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Robo4 is a transmembrane protein that regulates vascular permeability. Zhang et al. now reveal the mechanism of Robo4 action and show that Robo4 and UncB are required for VEGF-mediated regulation of vascular barrier by suppressing VEGF-induced phosph
Externí odkaz:
https://doaj.org/article/96fad901a4ef46c28beb417658674b86
Autor:
Antonia M. Joussen, Oliver Zeitz, Alexandre Dubrac, Thore Bürgel, Dominika Pohlmann, Steffen E. Künzel, Sandrine H. Künzel
Publikováno v:
Retina. 42:236-243
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8ca9bc0d815ec3227877e2956fecf1a
https://doi.org/10.1097/iae.0000000000003320
https://doi.org/10.1097/iae.0000000000003320
Autor:
Andreas Bikfalvi, Hervé Prats, Martin Hagedorn, Abdel-Majid Khatib, Abderrahim Lomri, Kim Clarke, Shih-Che Sue, Vincent Castronovo, Martin Schilling, Raphael Pineau, Anne Couvelard, Harald Wodrich, Fabienne Rayne, Thomas Daubon, Renaud Grepin, Marie Sire, Laurent Dumartin, Florence Darlot, Fabienne Soulet, Clotilde Billottet, Alexandre Dubrac, Kevin Boyé, Jessica Baud, Cathy Quemener
CXCR3 gene expression analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e272e85737905e2b0c180ce4babf1d
https://doi.org/10.1158/0008-5472.22409831.v1
https://doi.org/10.1158/0008-5472.22409831.v1
