Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Alexandre, Bougdour"'
Autor:
Manickam Yogavel, Alexandre Bougdour, Siddhartha Mishra, Nipun Malhotra, Jyoti Chhibber-Goel, Valeria Bellini, Karl Harlos, Benoît Laleu, Mohamed-Ali Hakimi, Amit Sharma
Publikováno v:
PLoS Pathogens, Vol 19, Iss 2, p e1011124 (2023)
The prolyl-tRNA synthetase (PRS) is a validated drug target for febrifugine and its synthetic analog halofuginone (HFG) against multiple apicomplexan parasites including Plasmodium falciparum and Toxoplasma gondii. Here, a novel ATP-mimetic centered
Externí odkaz:
https://doaj.org/article/e8c18ac0c4d34cadb55ade27bc2b2c94
Autor:
Yogavel Manickam, Nipun Malhotra, Siddhartha Mishra, Palak Babbar, Abhishek Dusane, Benoît Laleu, Valeria Bellini, Mohamed-Ali Hakimi, Alexandre Bougdour, Amit Sharma
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010363 (2022)
Toxoplasmosis is caused by Toxoplasma gondii and in immunocompromised patients it may lead to seizures, encephalitis or death. The conserved enzyme prolyl-tRNA synthetase (PRS) is a validated druggable target in Toxoplasma gondii but the traditional
Externí odkaz:
https://doaj.org/article/41402e30ad6545e083b42016c9121930
Autor:
Dayana C Farhat, Matthew W Bowler, Guillaume Communie, Dominique Pontier, Lucid Belmudes, Caroline Mas, Charlotte Corrao, Yohann Couté, Alexandre Bougdour, Thierry Lagrange, Mohamed-Ali Hakimi, Christopher Swale
Publikováno v:
eLife, Vol 10 (2021)
Correct 3’end processing of mRNAs is one of the regulatory cornerstones of gene expression. In a parasite that must adapt to the regulatory requirements of its multi-host life style, there is a need to adopt additional means to partition the distin
Externí odkaz:
https://doaj.org/article/88128cb858e5426693c5709fdfe3669c
Autor:
Valeria Bellini, Christopher Swale, Marie-Pierre Brenier-Pinchart, Tiffany Pezier, Sonia Georgeault, Fabrice Laurent, Mohamed-Ali Hakimi, Alexandre Bougdour
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101871- (2020)
Summary: Boron-containing compounds represent a promising class of molecules with proven efficacy against a wide range of pathogens, including apicomplexan parasites. Following lead optimization, the benzoxaborole AN13762 was identified as a preclini
Externí odkaz:
https://doaj.org/article/c725b458c075442e97bae02c47af5726
Autor:
Andrés Palencia, Alexandre Bougdour, Marie‐Pierre Brenier‐Pinchart, Bastien Touquet, Rose‐Laurence Bertini, Cristina Sensi, Gabrielle Gay, Julien Vollaire, Véronique Josserand, Eric Easom, Yvonne R Freund, Hervé Pelloux, Philip J Rosenthal, Stephen Cusack, Mohamed‐Ali Hakimi
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 3, Pp 385-394 (2017)
Abstract Toxoplasma gondii is an important food and waterborne pathogen causing toxoplasmosis, a potentially severe disease in immunocompromised or congenitally infected humans. Available therapeutic agents are limited by suboptimal efficacy and freq
Externí odkaz:
https://doaj.org/article/96892dd7fa464077a75b0e590d1fd393
Autor:
Ana Vera Antunes, Martina Shahinas, Christopher Swale, Dayana C. Farhat, Chandra Ramakrishnan, Christophe Bruley, Dominique Cannella, Charlotte Corrao, Yohann Couté, Adrian B. Hehl, Alexandre Bougdour, Isabelle Coppens, Mohamed-Ali Hakimi
Publikováno v:
bioRxiv
Summary paragraphSexual reproduction ofToxoplasma gondii, which is restricted to the small intestine of felids, is sparsely documented, due to ethical concerns surrounding the use of cats as model organisms. Chromatin modifiers dictate the developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc385b1c65c9d9f4d966c9b188c4acc5
https://www.zora.uzh.ch/id/eprint/228599/
https://www.zora.uzh.ch/id/eprint/228599/
Autor:
Huan He, Marie-Pierre Brenier-Pinchart, Laurence Braun, Alexandra Kraut, Bastien Touquet, Yohann Couté, Isabelle Tardieux, Mohamed-Ali Hakimi, Alexandre Bougdour
Publikováno v:
eLife, Vol 7 (2018)
The intracellular parasite Toxoplasma gondii, hijacks evolutionarily conserved host processes by delivering effector proteins into the host cell that shift gene expression in a timely fashion. We identified a parasite dense granule protein as GRA18 t
Externí odkaz:
https://doaj.org/article/9f4af3ae43a040d99a4cdda4b1d4ea50
Autor:
Fabien Sindikubwabo, Shuai Ding, Tahir Hussain, Philippe Ortet, Mohamed Barakat, Sebastian Baumgarten, Dominique Cannella, Andrés Palencia, Alexandre Bougdour, Lucid Belmudes, Yohann Couté, Isabelle Tardieux, Cyrille Y Botté, Artur Scherf, Mohamed-ali Hakimi
Publikováno v:
eLife, Vol 6 (2017)
An unusual genome architecture characterizes the two related human parasitic pathogens Plasmodium falciparum and Toxoplasma gondii. A major fraction of the bulk parasite genome is packaged as transcriptionally permissive euchromatin with few loci emb
Externí odkaz:
https://doaj.org/article/29a46b45901548e0861e8f922ce14127
Autor:
Christopher Swale, Valeria Bellini, Matthew W. Bowler, Nardella Flore, Marie-Pierre Brenier-Pinchart, Dominique Cannella, Lucid Belmudes, Caroline Mas, Yohann Couté, Fabrice Laurent, Artur Scherf, Alexandre Bougdour, Mohamed-Ali Hakimi
Publikováno v:
Science Translational Medicine
Science Translational Medicine, 2022, 14 (656), 17 p. ⟨10.1126/scitranslmed.abn3231⟩
Science Translational Medicine, 2022, 14 (656), 17 p. ⟨10.1126/scitranslmed.abn3231⟩
The Apicomplexa comprise a large phylum of single-celled, obligate intracellular protozoa that include Toxoplasma gondii , Plasmodium , and Cryptosporidium spp., which infect humans and animals and cause severe parasitic diseases. Available therapeut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de76e35bb8f730d44d078cf069e915a
https://hal.inrae.fr/hal-03752215
https://hal.inrae.fr/hal-03752215
Autor:
Christopher, Swale, Valeria, Bellini, Matthew W, Bowler, Nardella, Flore, Marie-Pierre, Brenier-Pinchart, Dominique, Cannella, Lucid, Belmudes, Caroline, Mas, Yohann, Couté, Fabrice, Laurent, Artur, Scherf, Alexandre, Bougdour, Mohamed-Ali, Hakimi
Publikováno v:
Science translational medicine. 14(656)
The Apicomplexa comprise a large phylum of single-celled, obligate intracellular protozoa that include
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c303e5ad1e9988ac7a1072ed6309224c
https://pubmed.ncbi.nlm.nih.gov/35921477
https://pubmed.ncbi.nlm.nih.gov/35921477