Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Alexandre, Alcaïs"'
Autor:
Monica Dallmann-Sauer, Yong Zhong Xu, Ana Lúcia França da Costa, Shao Tao, Tiago Araujo Gomes, Rhana Berto da Silva Prata, Wilian Correa-Macedo, Jérémy Manry, Alexandre Alcaïs, Laurent Abel, Aurélie Cobat, Vinicius M Fava, Roberta Olmo Pinheiro, Flavio Alves Lara, Christian M Probst, Marcelo T Mira, Erwin Schurr
Publikováno v:
PLoS Pathogens, Vol 19, Iss 3, p e1011260 (2023)
Leprosy, caused by Mycobacterium leprae, rarely affects children younger than 5 years. Here, we studied a multiplex leprosy family that included monozygotic twins aged 22 months suffering from paucibacillary leprosy. Whole genome sequencing identifie
Externí odkaz:
https://doaj.org/article/4ecae232e9fb4df9b33a140cb5f24d8c
Autor:
Vinicius M Fava, Monica Dallmann-Sauer, Marianna Orlova, Wilian Correa-Macedo, Nguyen Van Thuc, Vu Hong Thai, Alexandre Alcaïs, Laurent Abel, Aurélie Cobat, Erwin Schurr
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 12, p e0010029 (2021)
Leprosy is the second most prevalent mycobacterial disease globally. Despite the existence of an effective therapy, leprosy incidence has consistently remained above 200,000 cases per year since 2010. Numerous host genetic factors have been identifie
Externí odkaz:
https://doaj.org/article/084d0a397c8542769f79c1fd1fb72f27
Autor:
Jocelyn Quistrebert, Marianna Orlova, Gaspard Kerner, Le Thi Ton, Nguyễn Trong Luong, Nguyễn Thanh Danh, Quentin B Vincent, Fabienne Jabot-Hanin, Yoann Seeleuthner, Jacinta Bustamante, Stéphanie Boisson-Dupuis, Nguyen Thu Huong, Nguyen Ngoc Ba, Jean-Laurent Casanova, Christophe Delacourt, Eileen G Hoal, Alexandre Alcaïs, Vu Hong Thai, Lai The Thành, Laurent Abel, Erwin Schurr, Aurélie Cobat
Publikováno v:
PLoS Genetics, Vol 17, Iss 3, p e1009392 (2021)
The natural history of tuberculosis (TB) is characterized by a large inter-individual outcome variability after exposure to Mycobacterium tuberculosis. Specifically, some highly exposed individuals remain resistant to M. tuberculosis infection, as in
Externí odkaz:
https://doaj.org/article/4f7beee9588e480d8337e49640f11266
Autor:
Monica Dallmann-Sauer, Vinicius M Fava, Chaïma Gzara, Marianna Orlova, Nguyen Van Thuc, Vu Hong Thai, Alexandre Alcaïs, Laurent Abel, Aurélie Cobat, Erwin Schurr
Publikováno v:
PLoS Pathogens, Vol 16, Iss 8, p e1008818 (2020)
Leprosy is a chronic disease caused by Mycobacterium leprae. Worldwide, more than 200,000 new patients are affected by leprosy annually, making it the second most common mycobacterial disease after tuberculosis. The MHC/HLA region has been consistent
Externí odkaz:
https://doaj.org/article/9a062af1f998473d99cbcb8dc8fe7f2f
Autor:
Chaima Gzara, Monica Dallmann-Sauer, Marianna Orlova, Nguyen Van Thuc, Vu Hong Thai, Vinicius M Fava, Marie-Thérèse Bihoreau, Anne Boland, Laurent Abel, Alexandre Alcaïs, Erwin Schurr, Aurélie Cobat
Publikováno v:
PLoS Pathogens, Vol 16, Iss 5, p e1008565 (2020)
Leprosy is a chronic infectious disease of the skin and peripheral nerves with a strong genetic predisposition. Recent genome-wide approaches have identified numerous common variants associated with leprosy, almost all in the Chinese population. We c
Externí odkaz:
https://doaj.org/article/cbc174f2581440d980692f23d6e3d9e5
Autor:
Quentin B Vincent, Aziz Belkadi, Cindy Fayard, Estelle Marion, Ambroise Adeye, Marie-Françoise Ardant, Christian R Johnson, Didier Agossadou, Lazaro Lorenzo, Julien Guergnon, Christine Bole-Feysot, Jeremy Manry, Patrick Nitschké, Ioannis Theodorou, Jean-Laurent Casanova, Laurent Marsollier, Annick Chauty, Laurent Abel, Alexandre Alcaïs, Franco-Beninese Buruli Research Group
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 4, p e0006429 (2018)
Buruli ulcer (BU), the third most frequent mycobacteriosis worldwide, is a neglected tropical disease caused by Mycobacterium ulcerans. We report the clinical description and extensive genetic analysis of a consanguineous family from Benin comprising
Externí odkaz:
https://doaj.org/article/2a4aea9d19de4a06a26d84c830577bec
Autor:
Vinicius M Fava, Jeremy Manry, Aurélie Cobat, Marianna Orlova, Nguyen Van Thuc, Milton O Moraes, Carolinne Sales-Marques, Mariane M A Stefani, Ana Carla P Latini, Andrea F Belone, Vu Hong Thai, Laurent Abel, Alexandre Alcaïs, Erwin Schurr
Publikováno v:
PLoS Genetics, Vol 13, Iss 2, p e1006637 (2017)
Leprosy Type-1 Reactions (T1Rs) are pathological inflammatory responses that afflict a sub-group of leprosy patients and result in peripheral nerve damage. Here, we employed a family-based GWAS in 221 families with 229 T1R-affect offspring with stepw
Externí odkaz:
https://doaj.org/article/c055f3b3c45441308fad25fe8cb6774b
Autor:
Jean Gaschignard, Audrey Virginia Grant, Nguyen Van Thuc, Marianna Orlova, Aurélie Cobat, Nguyen Thu Huong, Nguyen Ngoc Ba, Vu Hong Thai, Laurent Abel, Erwin Schurr, Alexandre Alcaïs
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 5, p e0004345 (2016)
After sustained exposure to Mycobacterium leprae, only a subset of exposed individuals develops clinical leprosy. Moreover, leprosy patients show a wide spectrum of clinical manifestations that extend from the paucibacillary (PB) to the multibacillar
Externí odkaz:
https://doaj.org/article/89363a25265d40cb893b9e96e400ad94
Autor:
Vinicius M Fava, Jérémy Manry, Aurélie Cobat, Marianna Orlova, Nguyen Van Thuc, Nguyen Ngoc Ba, Vu Hong Thai, Laurent Abel, Alexandre Alcaïs, Erwin Schurr, Canadian Lrrk2 in Inflammation Team (CLINT)
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 2, p e0004412 (2016)
Depending on the epidemiological setting, a variable proportion of leprosy patients will suffer from excessive pro-inflammatory responses, termed type-1 reactions (T1R). The LRRK2 gene encodes a multi-functional protein that has been shown to modulat
Externí odkaz:
https://doaj.org/article/2d0ef309b71846b79607e3d14d753f3f
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 107, Iss suppl 1, Pp 132-142 (2012)
Type-1 (T1R) and Type-2 (T2R) leprosy reactions (LR), which affect up to 50% of leprosy patients, are aggressive inflammatory episodes of sudden onset and highly variable incidence across populations. LR are often diagnosed concurrently with leprosy,
Externí odkaz:
https://doaj.org/article/101f2e6c979248169266e78f0bf6e3ea