Polymorphisms in the NFkB, TNF-alpha, IL-1beta, and IL-18 pathways are associated with response to anti-TNF therapy in Danish patients with inflammatory bowel disease

Autor: Bank, Steffen, Julsgaard, Mette, Abed, Osama Karim, Burisch, Johan, Brodersen, Jacob Broder, Pedersen, Natalia Konstantinovich, Gouliaev, Anja, Ajan, Rullah, Rasmussen, Ditlev Nytoft, Grauslund, Camilla Honore, Roug, Stine, Galsgaard, Julie, Finsen, David Sprogoe Hoyer, Lindby, Karoline, Sorensen, Jeanette, Larsen, Lone, Andersen, Malene Rohr, Brandslund, Ivan, Thomassen, Mads, Green, Anders, Bojesen, Anders Bo, Sorensen, Signe Bek, Vogel, Ulla, Andersen, Vibeke, Bergmann, Ann Christina, Andersen, Paal Skytt, Rashid, Shaista, Lund, Britta Ornfelt, Rasmussen, Britt Kaiser, Avlund, Sara, Nielsen, Marie Odum, Bramstang, Eva Karolina Nilsdotter, Poulsen, Anja, Rudbeck-Resdal, Ditte, Aamann, Luise, Alexandraki, Maria Joanna, Foroutani, Ali, Molzen, Line, Hatrop, Anders, Rittig, Charlotte Siggaard, Stenbog, Elisabeth, Hedback, Nora Elisabeth, Nielsen, Rasmus Gaardskaer, Schiodt, Frank Vinholt, Carlsen, Katrine, Dessau, Ram Benny, Hoffmann, Hans Jurgen, Nexo, Bjorn Andersen, Sode, Jacob

Publikováno v: Bank, S, Julsgaard, M, Abed, O K, Burisch, J, Broder Brodersen, J, Pedersen, N K, Gouliaev, A, Ajan, R, Nytoft Rasmussen, D, Honore Grauslund, C, Roug, S, Galsgaard, J, Sprogøe Høyer Finsen, D, Lindby, K, Group, T D IBD G W, Sørensen, J, Larsen, L, Rohr Andersen, M, Brandslund, I, Thomassen, M, Green, A, Bo Bojesen, A, Bek Sørensen, S, Vogel, U & Andersen, V 2019, ' Polymorphisms in the NFkB, TNF-alpha, IL-1beta, and IL-18 pathways are associated with response to anti-TNF therapy in Danish patients with inflammatory bowel disease ', Alimentary Pharmacology & Therapeutics, vol. 49, no. 7, pp. 890-903 . https://doi.org/10.1111/apt.15187
Danish IBD Genetics Working Grp 2019, ' Polymorphisms in the NFkB, TNF-alpha, IL-1beta, and IL-18 pathways are associated with response to anti-TNF therapy in Danish patients with inflammatory bowel disease ' Alimentary Pharmacology and Therapeutics, vol. 49, no. 7, pp. 890-903 . https://doi.org/10.1111/apt.15187
Bank, S, Julsgaard, M, Abed, O K, Burisch, J, Broder Brodersen, J, Pedersen, N K, Gouliaev, A, Ajan, R, Nytoft Rasmussen, D, Honore Grauslund, C, Roug, S, Galsgaard, J, Sprogøe Høyer Finsen, D, Lindby, K, Danish IBD Genetics Working Group, Sørensen, J, Larsen, L, Rohr Andersen, M, Brandslund, I, Thomassen, M, Green, A, Bo Bojesen, A, Bek Sørensen, S, Vogel, U & Andersen, V 2019, ' Polymorphisms in the NFkB, TNF-alpha, IL-1beta, and IL-18 pathways are associated with response to anti-TNF therapy in Danish patients with inflammatory bowel disease ', Alimentary Pharmacology and Therapeutics, vol. 49, no. 7, pp. 890-903 . https://doi.org/10.1111/apt.15187
Bank, S, Julsgaard, M, Abed, O K, Burisch, J, Broder Brodersen, J, Pedersen, N K, Gouliaev, A, Ajan, R, Nytoft Rasmussen, D, Honore Grauslund, C, Roug, S, Galsgaard, J, Sprogøe Høyer Finsen, D, Lindby, K, Sørensen, J, Larsen, L, Rohr Andersen, M, Brandslund, I, Thomassen, M, Green, A, Bo Bojesen, A, Bek Sørensen, S, Vogel, U, Andersen, V & The Danish IBD Genetics Working Group 2019, ' Polymorphisms in the NFkB, TNF-alpha, IL-1beta, and IL-18 pathways are associated with response to anti-TNF therapy in Danish patients with inflammatory bowel disease ', Alimentary Pharmacology and Therapeutics, vol. 49, no. 7, pp. 890-903 . https://doi.org/10.1111/apt.15187
Bank, S, Julsgaard, M, Abed, O K, Burisch, J, Brodersen, J B, Pedersen, N K, Gouliaev, A, Ajan, R, Rasmussen, D N, Grauslund, C H, Roug, S, Galsgaard, J, Finsen, D S H, Lindby, K, Sorensen, J, Larsen, L, Andersen, M R, Brandslund, I, Thomassen, M, Green, A, Bojesen, A B, Sorensen, S B, Vogel, U, Andersen, V, Bergmann, A C, Andersen, P S, Rashid, S, Lund, B O, Rasmussen, B K, Avlund, S, Nielsen, M O, Bramstang, E K N, Poulsen, A, Rudbeck-Resdal, D, Aamann, L, Alexandraki, M J, Foroutani, A, Molzen, L, Hatrop, A, Rittig, C S, Stenbog, E, Hedback, N E, Nielsen, R G, Schiodt, F V, Carlsen, K, Dessau, R B, Hoffmann, H J, Nexo, B A & Sode, J 2019, ' Polymorphisms in the NFkB, TNF-alpha, IL-1beta, and IL-18 pathways are associated with response to anti-TNF therapy in Danish patients with inflammatory bowel disease ', Alimentary Pharmacology and Therapeutics, vol. 49, no. 7, pp. 890-903 . https://doi.org/10.1111/apt.15187

BackgroundAnti‐tumor necrosis factor‐α (TNF‐α) is used for the treatment of severe cases of IBD, including Crohn's disease (CD) and ulcerative colitis (UC). However, one‐third of the patients do not respond to the treatment. We have previou

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