Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alexandra-Roxana Ilie"'
Autor:
Harriet Bennett-Lenane, Joseph P. O’Shea, Jack D. Murray, Alexandra-Roxana Ilie, René Holm, Martin Kuentz, Brendan T. Griffin
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1398 (2021)
In response to the increasing application of machine learning (ML) across many facets of pharmaceutical development, this pilot study investigated if ML, using artificial neural networks (ANNs), could predict the apparent degree of supersaturation (a
Externí odkaz:
https://doaj.org/article/7b06bc13a1894a9ba8b0eaab5f9147a4
Autor:
René Holm, Koen Wuyts, Ruzica Kolakovic, Brendan T. Griffin, Martin Kuentz, Filip Cuyckens, Alexandra Roxana Ilie, Maria Vertzoni
Publikováno v:
Drug Development and Industrial Pharmacy
This study aimed to systematically explore compositional effects for a series of lipid systems, on the in vitro drug solubilization and in vivo bioavailability of three poorly water-soluble drugs with different physico-chemical properties. While many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc88a0e5b0bc15833b2590922259b7a
https://hdl.handle.net/10468/10811
https://hdl.handle.net/10468/10811
Autor:
Alexandra Roxana Ilie, Ruzica Kolakovic, Brendan T. Griffin, Hugo Bohets, Maria Vertzoni, Jilly Herman, Ahmed Malash, René Holm, Martin Kuentz, Anke Prudic-Paus
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 159
Supersaturated lipid-based drug delivery systems are increasingly being explored as a bio-enabling formulation approach, particularly in preclinical evaluation of poorlywater-soluble drugs. While increasing the drug load through thermally-induced sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::766547844e3a708869ff8ce26c603e6e
https://pubmed.ncbi.nlm.nih.gov/33359616
https://pubmed.ncbi.nlm.nih.gov/33359616
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 118
The aim of this observational review was to review trends in deficiencies in clinical pharmacology dossiers by analysing the frequency and characteristics of major objections (MOs) related to clinical pharmacokinetics and dose-exposure-response (DER)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172c2eeaa56197d161110401d69ba1ea
https://pubmed.ncbi.nlm.nih.gov/33049309
https://pubmed.ncbi.nlm.nih.gov/33049309
Autor:
Alexandra-Roxana, Ilie, Brendan T, Griffin, Martin, Brandl, Annette, Bauer-Brandl, Ann-Christin, Jacobsen, Maria, Vertzoni, Martin, Kuentz, Ruzica, Kolakovic, René, Holm
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 152
Supersaturated lipid-based drug delivery systems have recently been investigated for oral administration for a variety of lipophilic drugs and have shown either equivalent or superior oral bioavailability compared to conventional non-supersaturated l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::65d1fb3e880d10a811c0309d8f4761f0
https://pubmed.ncbi.nlm.nih.gov/32622980
https://pubmed.ncbi.nlm.nih.gov/32622980
Autor:
Ruzica Kolakovic, Brendan T. Griffin, Maria Vertzoni, Martin Kuentz, Alexandra Roxana Ilie, René Holm
Publikováno v:
Drug Development and Industrial Pharmacy
Objective: The objective of this study was to systematically investigate the impact of lipid composition on the ability to design supersaturated lipid-based drug delivery systems (sLBDDS) using three model drugs with different physico-chemical proper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c5e0a1d7d64e65fd1dc8b6ff55d38d
https://hdl.handle.net/10468/9614
https://hdl.handle.net/10468/9614
Autor:
Georgia Tsakiridou, René Holm, Felix Ditzinger, Martin Kuentz, Lida Kalantzi, Brendan T. Griffin, Sandra Jankovic, Alexandra-Roxana Ilie, Daniel J. Price, Christoph Saal, Niklas J Köhl, Anita Nair, Simone Aleandri
Publikováno v:
Journal of Pharmacy and Pharmacology
Objectives This review highlights aspects of drug hydrophobicity and lipophilicity as determinants of different oral formulation approaches with specific focus on enabling formulation technologies. An overview is provided on appropriate formulation s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84ef949fecd678692f1cae798e497c84
https://pubmed.ncbi.nlm.nih.gov/30070363
https://pubmed.ncbi.nlm.nih.gov/30070363
Autor:
Niklas J. Koehl, Alexandra-Roxana Ilie, Georgia Tsakiridou, Lida Kalantzi, Brendan T. Griffin, Sandra Jankovic, Martin Kuentz, René Holm, Christoph Saal, Felix Ditzinger, Daniel J. Price, Anita Nair, Kristof Kimpe
Publikováno v:
Journal of Pharmacy and Pharmacology
Objectives Solubility parameters have been used for decades in various scientific fields including pharmaceutics. It is, however, still a field of active research both on a conceptual and experimental level. This work addresses the need to review sol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52f9cd35b4b90b87e85940ecfd7d72f
Autor:
Martin Brandl, Ruzica Kolakovic, Brendan T. Griffin, Maria Vertzoni, René Holm, Ann-Christin Jacobsen, Alexandra-Roxana Ilie, Annette Bauer-Brandl, Martin Kuentz
Publikováno v:
European Journal of Pharmaceutical Sciences
Ilie, A-R, Griffin, B T, Brandl, M, Bauer-Brandl, A, Jacobsen, A-C, Vertzoni, M, Kuentz, M, Kolakovic, R & Holm, R 2020, ' Exploring impact of supersaturated lipid-based drug delivery systems of celecoxib on in vitro permeation across PermeapadⓇ membrane and in vivo absorption ', European Journal of Pharmaceutical Sciences, vol. 152, 105452 . https://doi.org/10.1016/j.ejps.2020.105452
Ilie, A-R, Griffin, B T, Brandl, M, Bauer-Brandl, A, Jacobsen, A-C, Vertzoni, M, Kuentz, M, Kolakovic, R & Holm, R 2020, ' Exploring impact of supersaturated lipid-based drug delivery systems of celecoxib on in vitro permeation across PermeapadⓇ membrane and in vivo absorption ', European Journal of Pharmaceutical Sciences, vol. 152, 105452 . https://doi.org/10.1016/j.ejps.2020.105452
Supersaturated lipid-based drug delivery systems have recently been investigated for oral administration for a variety of lipophilic drugs and have shown either equivalent or superior oral bioavailability compared to conventional non-supersaturated l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd713d23c319e84e54eb881d3b91e377