Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Alexandra Zanin-Zhorov"'
Autor:
Alexandra Zanin-Zhorov, Wei Chen, Julien Moretti, Melanie S. Nyuydzefe, Iris Zhorov, Rashmi Munshi, Malavika Ghosh, Cindy Serdjebi, Kelli MacDonald, Bruce R. Blazar, Melissa Palmer, Samuel D. Waksal
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract The pathogenesis of hepatic fibrosis is driven by dysregulated metabolism precipitated by chronic inflammation. Rho-associated coiled-coil-containing protein kinases (ROCKs) have been implicated in these processes, however the ability of sel
Externí odkaz:
https://doaj.org/article/1360ef435b4a4bcb8e0d0bb6c03f33cd
Autor:
Wei Chen, Melanie S. Nyuydzefe, Jonathan M. Weiss, Jingya Zhang, Samuel D. Waksal, Alexandra Zanin-Zhorov
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Rho-associated coiled-coil kinase (ROCK)2 targeting down-regulates autoimmune responses in animal models and patients, however the underlying molecular mechanism is still an enigma. We report that ROCK2 binds phosphorylated-STAT3 and its kin
Externí odkaz:
https://doaj.org/article/161f3b2af832421d851906abac38085c
Autor:
Alexandra Zanin-Zhorov, Sudha Kumari, Keli L. Hippen, Sarah C. Merkel, Margaret L. MacMillan, Bruce R. Blazar, Michael L. Dustin
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract In vitro induced human regulatory T cells (iTregs) have demonstrated in vivo therapeutic utility, but pathways regulating their function have not been elucidated. Here, we report that human iTregs generated in vitro from naïve cord blood ce
Externí odkaz:
https://doaj.org/article/e68bbe646c9d458cb1c2346218358f5d
Autor:
Madan Jagasia, Jeegar Patel, James Essell, Sanjay K. Aggarwal, Bruce R. Blazar, David Eiznhamer, Laurie S. Green, Zhongming Yang, Aleksandr Lazaryan, Jonathan M. Weiss, Behyar Zoghi, Stephanie J. Lee, Olivier Schueller, Daniel J. Weisdorf, Amandeep Salhotra, Alexandra Zanin-Zhorov, Carlos Bachier
Publikováno v:
Journal of Clinical Oncology. 39:1888-1898
PURPOSE The rho-associated coiled-coil–containing protein kinase-2 (ROCK2) signaling pathway regulates the Th17/regulatory T cells balance and controls profibrotic pathways. Selective ROCK2 inhibition with belumosudil (KD025) may offer a novel appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3112cd95715a5753793d3fd037afba
https://doi.org/10.1200/jco.20.02754
https://doi.org/10.1200/jco.20.02754
Autor:
Alexandra Zanin-Zhorov, Wei Chen, Melanie Nyuydzefe, Julien Moretti, Iris Zhorov, Rashmi Munshi, Malavika Ghosh, Kelli MacDonald, Bruce Blazar, Sam Waksal
Publikováno v:
Journal of Hepatology. 77:S494-S495
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d809f8fa669d1843a8655bc04287198c
https://doi.org/10.1016/s0168-8278(22)01319-8
https://doi.org/10.1016/s0168-8278(22)01319-8
Publikováno v:
Clin Immunol
Chronic graft-versus-host disease (cGVHD) is an immune-mediated disorder characterized by chronic inflammation and fibrosis. Rho-associated coiled-coil-containing protein kinases (ROCKs) are key coordinators of tissue response to injury, regulating m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64cbef1c323e2534a43c0ff5fbf1bc92
https://europepmc.org/articles/PMC8456981/
https://europepmc.org/articles/PMC8456981/
Autor:
Michael L. Dustin, Keli L. Hippen, Sarah C. Merkel, Bruce R. Blazar, Alexandra Zanin-Zhorov, Sudha Kumari, Margaret L. MacMillan
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020)
In vitro induced human regulatory T cells (iTregs) have demonstrated in vivo therapeutic utility, but pathways regulating their function have not been elucidated. Here, we report that human iTregs generated in vitro from naïve cord blood cells prefe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de2c51e892303da972883e110c5fa2d
http://europepmc.org/articles/PMC7031276
http://europepmc.org/articles/PMC7031276
Autor:
Bruce R. Blazar, Gregory Miller, Wei Chen, Jing Liu, Melanie S. Nyuydzefe, Geoffrey R. Hill, Katharine M. Irvine, Michelle Melino, Wayne A. Schroder, Patrick Bertolino, Kelli P. A. MacDonald, Alexandra Zanin-Zhorov, Michele W.L. Teng, Christina Nalkurthi, Andrew D. Clouston
Publikováno v:
JHEP Reports
Background & Aims Fibrosis, the primary cause of morbidity in chronic liver disease, is induced by pro-inflammatory cytokines, immune cell infiltrates, and tissue resident cells that drive excessive myofibroblast activation, collagen production, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d909aee919cee8dee5b9a4e06674119f
https://doi.org/10.1016/j.jhepr.2021.100386
https://doi.org/10.1016/j.jhepr.2021.100386
Autor:
Melanie S. Nyuydzefe, Alexandra Zanin-Zhorov, Wei Chen, Jingya Zhang, Samuel D. Waksal, Jonathan M. Weiss
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports
Rho-associated coiled-coil kinase (ROCK)2 targeting down-regulates autoimmune responses in animal models and patients, however the underlying molecular mechanism is still an enigma. We report that ROCK2 binds phosphorylated-STAT3 and its kinase activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de66cab8c8046b589dcb52cfafbce754
https://doaj.org/article/161f3b2af832421d851906abac38085c
https://doaj.org/article/161f3b2af832421d851906abac38085c
Autor:
Melanie S. Nyuydzefe, Jonathan M. Weiss, David Kitzenberg, Jingya Zhang, Suzhao Li, Charles A. Dinarello, Wei Chen, Isak W. Tengesdal, Alexandra Zanin-Zhorov, Samuel D. Waksal
Publikováno v:
European Journal of Immunology, 48, 10, pp. 1679-1686
European Journal of Immunology, 48, 1679-1686
European Journal of Immunology, 48, 1679-1686
Contains fulltext : 196332.pdf (Publisher’s version ) (Closed access) Reducing the activities of the pro-inflammatory cytokine IL-17 is an effective treatment strategy for several chronic autoimmune disorders. Rho-associated coiled-coil containing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a48407501c1c02ba6c3f824760994c
https://doi.org/10.1002/eji.201847652
https://doi.org/10.1002/eji.201847652