Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Alexandra Wittmann"'
Autor:
Elizabeth C. Goode, Laura Fachal, Nikolaos Panousis, Loukas Moutsianas, Rebecca E. McIntyre, Benjamin Yu Hang Bai, Norihito Kawasaki, Alexandra Wittmann, Tim Raine, Simon M. Rushbrook, Carl A. Anderson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Genome-wide association studies of primary sclerosing cholangitis have identified 23 susceptibility loci. The majority of these loci reside in non-coding regions of the genome and are thought to exert their effect by perturbing the regulatio
Externí odkaz:
https://doaj.org/article/0f8184604dce4d29a214066cecab7cb1
Autor:
Dimitra Lamprinaki, Gemma Beasy, Aleksandra Zhekova, Alexandra Wittmann, Steve James, Jo Dicks, Yoichiro Iwakura, Shinobu Saijo, Xiaomin Wang, Chung-Wai Chow, Ian Roberts, Tamas Korcsmaros, Ulrike Mayer, Thomas Wileman, Norihito Kawasaki
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
The human fungal microbiota known as mycobiota is increasingly recognized as a critical factor in human gut health and disease. Non-pathogenic commensal yeasts such as Saccharomyces cerevisiae promote homeostasis in the gut, whereas dysbiosis of the
Externí odkaz:
https://doaj.org/article/f90718b332bc4aaeae6b6c0d97709b4d
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71338 (2013)
In industrialized countries bacterial intestinal infections are commonly caused by enteropathogenic Enterobacteriaceae. The interaction of the microbiota with the host immune system determines the adequacy of an appropriate response against pathogens
Externí odkaz:
https://doaj.org/article/978fbc5994424aaa921bb922f52f001a
Autor:
Nathalie Juge, Norihito Kawasaki, Ian Black, Parastoo Azadi, Triinu Visnapuu, Gwénaëlle Le Gall, Dimitrios Latousakis, Sergey A. Nepogodiev, Ian D. Young, Robert A. Field, Alexandra Wittmann
Publikováno v:
Carbohydrate Polymers. 277:118606
Levan, a β-2,6 fructofuranose polymer produced by microbial species, has been reported for its immunomodulatory properties via interaction with toll-like receptor 4 (TLR4) which recognises lipopolysaccharide (LPS). However, the molecular mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e68467f641a7abed81eb6cc3cb4bf3cb
https://doi.org/10.1016/j.carbpol.2021.118606
https://doi.org/10.1016/j.carbpol.2021.118606
Autor:
Alexandra Wittmann, Sandra Tribolo, Karine Lecointe, Devon Kavanaugh, P.A. Gunning, Dimitrios Latousakis, Nathalie Juge, Donald A. MacKenzie, Norihito Kawasaki, Charlotte Leclaire
Publikováno v:
The FASEB Journal
Intestinal mucins trigger immune responses upon recognition by dendritic cells via protein-carbohydrate interactions. We used a combination of structural, biochemical, biophysical, and cell-based approaches to decipher the specificity of the interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b91edffc7e2b015905f85ff81afcd1
https://doi.org/10.1096/fj.201700619r
https://doi.org/10.1096/fj.201700619r
Autor:
Mar Villamiel, Agustín Olano, Norihito Kawasaki, Antonia Montilla, Alexandra Wittmann, Ian D. Young
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Lactulose-derived oligosaccharides (OsLu) are prebiotic galactooligosaccharides (GOS) beneficial for human health including immunomodulatory properties; however, the molecular mechanism is unclear. OsLu produced by enzymatic synthesis can be purified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ea13547f893410da6a5e8c3be05ff3
http://hdl.handle.net/10261/174145
http://hdl.handle.net/10261/174145
Autor:
Chris Whitfield, Shinobu Saijo, Yuriy A. Knirel, Ewa Katzenellenbogen, Takashi Nishimura, Dimitra Lamprinaki, Kazuo Yamamoto, Kristian M. Bowles, Alexandra Wittmann, Norihito Kawasaki, Yoichiro Iwakura, Naoki Matsumoto
Publikováno v:
The Journal of Biological Chemistry
Lipopolysaccharide (LPS) consists of a relatively conserved region of lipid A and core-oligosaccharide, and a highly variable region of O-antigen polysaccharide. While lipid A is known to bind to the toll-like receptor 4 (TLR4)-myeloid differentiatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aea453f15b424f4559609df6c0cc7a8
https://doi.org/10.1074/jbc.m116.741256
https://doi.org/10.1074/jbc.m116.741256
Autor:
Michiel Kleerebezem, Iris I. van Swam, Andrea I. Schäfer, Alexandra Wittmann, Annika Bender, Kerstin Gronbach, Raphael Parusel, Isabell Flade, Julia-Stefanie Frick, Ali Giray Korkmaz, Peter A. Bron, Ingo B. Autenrieth, Sarah Menz, Patrick Adam
Publikováno v:
Inflammatory Bowel Diseases, 21(3), 507-519
Inflammatory Bowel Diseases 21 (2015) 3
Inflammatory Bowel Diseases 21 (2015) 3
Background: Toll-like receptor (TLR) expression in patients with inflammatory bowel disease is increased when compared with healthy controls. However, the impact of TLR signaling during inflammatory bowel disease is not fully understood. Methods: In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdba794a3f29a58455b4fb2131fb9f8e
https://doi.org/10.1097/mib.0000000000000292
https://doi.org/10.1097/mib.0000000000000292
Autor:
Devon Kavanaugh, Nathalie Juge, Ian D. Young, Norihito Kawasaki, Allan P. Gunning, Alexandra Wittmann, Charlotte Leclaire, Krisztián Bene, Donald A. MacKenzie, Éva Rajnavölgyi
Publikováno v:
Frontiers in Microbiology
The vertebrate gut symbiont Lactobacillus reuteri exhibits strain-specific adhesion and health-promoting properties. Here, we investigated the role of the mucus adhesins, CmbA and MUB upon interaction with the L. reuteri strains ATCC PTA 6475 and ATC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee50c7a921bda3f32257c9ef209acdd0
http://europepmc.org/articles/PMC5339304
http://europepmc.org/articles/PMC5339304
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 8, p e71338 (2013)
PLoS ONE, Vol 8, Iss 8, p e71338 (2013)
In industrialized countries bacterial intestinal infections are commonly caused by enteropathogenic Enterobacteriaceae. The interaction of the microbiota with the host immune system determines the adequacy of an appropriate response against pathogens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f42774f9c30e74b1dc1870283ee7916
http://europepmc.org/articles/PMC3748105
http://europepmc.org/articles/PMC3748105