Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Alexandra Weiß"'
Autor:
James W. Gilbert, Zachary Kennedy, Bruno M.D.C. Godinho, Ashley Summers, Alexandra Weiss, Dimas Echeverria, Brianna Bramato, Nicholas McHugh, David Cooper, Ken Yamada, Matthew Hassler, Hélène Tran, Fen Biao Gao, Robert H. Brown, Jr., Anastasia Khvorova
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 3, Pp 102291- (2024)
A hexanucleotide (G4C2) repeat expansion (HRE) within intron one of C9ORF72 is the leading genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). C9ORF72 haploinsufficiency, formation of RNA foci, and production of di
Externí odkaz:
https://doaj.org/article/48f420ec0d5f4364889fb47b75a6618c
Autor:
Md Amin Hossain, Richa Sarin, Daniel P Donnelly, Brandon C Miller, Alexandra Weiss, Luke McAlary, Svetlana V Antonyuk, Joseph P Salisbury, Jakal Amin, Jeremy B Conway, Samantha S Watson, Jenifer N Winters, Yu Xu, Novera Alam, Rutali R Brahme, Haneyeh Shahbazian, Durgalakshmi Sivasankar, Swathi Padmakumar, Aziza Sattarova, Aparna C Ponmudiyan, Tanvi Gawde, David E Verrill, Wensheng Yang, Sunanda Kannapadi, Leigh D Plant, Jared R Auclair, Lee Makowski, Gregory A Petsko, Dagmar Ringe, Nathalie Y R Agar, David J Greenblatt, Mary Jo Ondrechen, Yunqiu Chen, Justin J Yerbury, Roman Manetsch, S Samar Hasnain, Robert H Brown, Jeffrey N Agar
Publikováno v:
PLoS Biology, Vol 22, Iss 1, p e3002462 (2024)
Mutations in the gene encoding Cu-Zn superoxide dismutase 1 (SOD1) cause a subset of familial amyotrophic lateral sclerosis (fALS) cases. A shared effect of these mutations is that SOD1, which is normally a stable dimer, dissociates into toxic monome
Externí odkaz:
https://doaj.org/article/ae0b075acaa84b09a950667731983ac1
Autor:
Minggang Fang, Sara K. Deibler, Alissa L. Nana, Sarat C. Vatsavayai, Shahid Banday, You Zhou, Sandra Almeida, Alexandra Weiss, Robert H. Brown, William W. Seeley, Fen-Biao Gao, Michael R. Green
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
A common pathological hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the cytoplasmic mislocalization and aggregation of the DNA/RNA-binding protein TDP-43, but how loss of nuclear TDP-43 function contributes to A
Externí odkaz:
https://doaj.org/article/a1d4f64536214ceb9ccfbc547d49b842
Autor:
Owen M. Peters, Alexandra Weiss, Jake Metterville, Lina Song, Robert Logan, Gaynor A. Smith, Michael A. Schwarzschild, Christian Mueller, Robert H. Brown, Marc Freeman
Publikováno v:
Neurobiology of Disease, Vol 155, Iss , Pp 105368- (2021)
Parkinson's disease (PD) is the most common form of neurodegenerative movement disorder, associated with profound loss of dopaminergic neurons from the basal ganglia. Though loss of dopaminergic neuron cell bodies from the substantia nigra pars compa
Externí odkaz:
https://doaj.org/article/61bd0e8a5ddc42d987d5cc6ee8708517
Autor:
Andrew J. S. Meijers, Michael P. Meredith, Emily F. Shuckburgh, Elizabeth C. Kent, David R. Munday, Yvonne L. Firing, Brian King, Tim J. Smyth, Melanie J. Leng, A. J. George Nurser, Helene T. Hewitt, E. Povl Abrahamsen, Alexandra Weiss, Mingxi Yang, Thomas G. Bell, J. Alexander Brearley, Emma J. D. Boland, Daniel C. Jones, Simon A. Josey, Robyn P. Owen, Jeremy P. Grist, Adam T. Blaker, Stavroula Biri, Margaret J. Yelland, Ciara Pimm, Shenjie Zhou, James Harle, Richard C. Cornes
The 5-year Ocean Regulation of Climate by Heat and Carbon Sequestration and Transports (ORCHESTRA) programme and its 1-year extension ENCORE (ENCORE is the National Capability ORCHESTRA Extension) was an approximately 11-million-pound programme invol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e05e0fc07b1a0f78b8ab9605214b58f
https://www.repository.cam.ac.uk/handle/1810/349610
https://www.repository.cam.ac.uk/handle/1810/349610
Autor:
Janice A. Dominov, Laura A. Madigan, Joshua P. Whitt, Katerina L. Rademacher, Kristin M. Webster, Hesheng Zhang, Haruhiko Banno, Siqi Tang, Yifan Zhang, Nicholas Wightman, Emma M. Shychuck, John Page, Alexandra Weiss, Karen Kelly, Alper Kucukural, Michael H. Brodsky, Alexander Jaworski, Justin R. Fallon, Diane Lipscombe, Robert H. Brown
Publikováno v:
bioRxiv
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disorder affecting brain and spinal cord motor neurons. Mutations in the copper/zinc superoxide dismutase gene (SOD1) are associated with ∼20% of inherited and 1-2% of sporadic ALS c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0de160fc2e91574d01f7d30c4af0729
https://doi.org/10.1101/2023.05.05.539444
https://doi.org/10.1101/2023.05.05.539444
Autor:
Ghadeer K Dawwas, Alexandra Weiss, Brad D Constant, Lauren E Parlett, Kevin Haynes, Jeff Yufeng Yang, Colleen Brensinger, Qufei Wu, Virginia Pate, Michele Jonsson Funk, Douglas E Schaubel, Andres Hurtado-Lorenzo, Michael David Kappelman, James D Lewis
Publikováno v:
Inflammatory Bowel Diseases.
Background To facilitate inflammatory bowel disease (IBD) research in the United States, we developed and validated claims-based definitions to identify incident and prevalent IBD diagnoses using administrative healthcare claims data among multiple p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0c190444322fd20ce8946ddcc38da15
https://doi.org/10.1093/ibd/izad053
https://doi.org/10.1093/ibd/izad053
Autor:
Magdalena Pühl, Anke Roiger, Alina Fiehn, Alan M. Gorchov Negron, Eric A. Kort, Stefan Schwietzke, Ignacio Pisso, Amy Foulds, James Lee, James L. France, Anna E. Jones, Dave Lowry, Rebecca E. Fisher, Langwen Huang, Jacob Shaw, Prudence Bateson, Stephen Andrews, Stuart Young, Pamela Dominutti, Tom Lachlan-Cope, Alexandra Weiss, Grant Allen
Atmospheric methane (CH4) concentrations have more than doubled since the beginning of the industrial age, making CH4 the second most important anthropogenic greenhouse gas after carbon dioxide (CO2). The oil and gas sector represent one of the major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a05b242fc2e848fd8e7b9bab3540efd9
https://acp.copernicus.org/preprints/acp-2022-826/
https://acp.copernicus.org/preprints/acp-2022-826/
Autor:
Ian A. Renfrew, Jie Huang, Stefanie Semper, Christopher Barrell, Annick Terpstra, Robert S. Pickart, Kjetil Våge, Andrew D. Elvidge, Thomas Spengler, Anna‐Marie Strehl, Alexandra Weiss
Publikováno v:
XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)
Quarterly Journal of the Royal Meteorological Society
Quarterly Journal of the Royal Meteorological Society
Marine cold-air outbreaks (CAO) are vigorous equatorward excursions of coldair over the ocean, responsible for the majority of wintertime oceanic heat lossfrom the subpolar seas of the North Atlantic. However, the impact of individualCAO events on th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb4be772413e2f8c5ca64ca85ccfc56e
https://gfzpublic.gfz-potsdam.de/pubman/item/item_5016501
https://gfzpublic.gfz-potsdam.de/pubman/item/item_5016501
Autor:
Hélène Tran, Michael P. Moazami, Huiya Yang, Diane McKenna-Yasek, Catherine L. Douthwright, Courtney Pinto, Jake Metterville, Minwook Shin, Nitasha Sanil, Craig Dooley, Ajit Puri, Alexandra Weiss, Nicholas Wightman, Heather Gray-Edwards, Miklos Marosfoi, Robert M. King, Thomas Kenderdine, Daniele Fabris, Robert Bowser, Jonathan K. Watts, Robert H. Brown
Publikováno v:
Nat Med
Expansions of a G(4)C(2) repeat in the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two devastating adult-onset neurodegenerative disorders. Using C9-ALS/FTD patient derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526bfed36a1119fec259b2da63c632b4
https://doi.org/10.1038/s41591-021-01557-6
https://doi.org/10.1038/s41591-021-01557-6