Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Alexandra Surcel"'
Autor:
Jens C. Hamann, Alexandra Surcel, Ruoyao Chen, Carolyn Teragawa, John G. Albeck, Douglas N. Robinson, Michael Overholtzer
Publikováno v:
Cell Reports, Vol 20, Iss 1, Pp 201-210 (2017)
Entosis is a mechanism of cell death that involves neighbor cell ingestion. This process occurs in cancers and promotes a form of cell competition, where winner cells engulf and kill losers. Entosis is driven by a mechanical differential that allows
Externí odkaz:
https://doaj.org/article/84311da285524b578a2a84e2f2fd339a
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2453 (2008)
Cohesin is the protein complex responsible for maintaining sister chromatid cohesion. Cohesin interacts with centromeres and specific loci along chromosome arms known as Chromosome Attachment Regions (CARs). The cohesin holocomplex contains four subu
Externí odkaz:
https://doaj.org/article/b994fadd386d4bb7b1ee5fa2aa9201a1
Autor:
Douglas N. Robinson, Robert A. Anders, Pablo A. Iglesias, Elizabeth M. Jaffee, Jochen Guck, Katarzyna Plak, Martin Kräter, Angela Jacobi, Hoku West-Foyle, Oliver Otto, Maik Herbig, Kathleen T. DiNapoli, Qingfeng Zhu, Dustin G. Thomas, Eric S. Schiffhauer, Alexandra Surcel
Supplemental materials include following: Supplemental Materials and Methods Table S1. NMII Concentration (n), nM Fig. S1. Model systems to human pancreatic cancer. Fig. S2. Scoring analysis and differential expression patterns of mechanoresponsive a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1e11fe630e8a886fabbba11032e3cb
https://doi.org/10.1158/0008-5472.22421015
https://doi.org/10.1158/0008-5472.22421015
Autor:
Douglas N. Robinson, Robert A. Anders, Pablo A. Iglesias, Elizabeth M. Jaffee, Jochen Guck, Katarzyna Plak, Martin Kräter, Angela Jacobi, Hoku West-Foyle, Oliver Otto, Maik Herbig, Kathleen T. DiNapoli, Qingfeng Zhu, Dustin G. Thomas, Eric S. Schiffhauer, Alexandra Surcel
Metastasis is complex, involving multiple genetic, epigenetic, biochemical, and physical changes in the cancer cell and its microenvironment. Cells with metastatic potential are often characterized by altered cellular contractility and deformability,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71b0d8acca13db0827f677cb3ab4757f
https://doi.org/10.1158/0008-5472.c.6510815.v1
https://doi.org/10.1158/0008-5472.c.6510815.v1
Autor:
Eric Schiffhauer, Elizabeth M. Jaffee, Quingfeng Zhu, Martin Kräter, Angela Jacobi, Oliver Otto, Alexandra Surcel, Maik Herbig, Katarzyna Plak, Robert A. Anders, Jochen Guck, Pablo A. Iglesias, Douglas N. Robinson, Dustin Thomas, Hoku West-Foyle, Kathleen T. DiNapoli
Publikováno v:
Cancer Research
Metastasis is complex, involving multiple genetic, epigenetic, biochemical, and physical changes in the cancer cell and its microenvironment. Cells with metastatic potential are often characterized by altered cellular contractility and deformability,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82cbf68ca89cda6981331d8555bc269a
https://doi.org/10.1158/0008-5472.can-18-3131
https://doi.org/10.1158/0008-5472.can-18-3131
Publikováno v:
Am J Physiol Cell Physiol
Cancer progression is dependent on heightened mechanical adaptation, both for the cells’ ability to change shape and to interact with varying mechanical environments. This type of adaptation is dependent on mechanoresponsive proteins that sense and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6cf7342f0b3d314d405fa898e87d5c0
https://pubmed.ncbi.nlm.nih.gov/33264076
https://pubmed.ncbi.nlm.nih.gov/33264076
Autor:
Douglas N. Robinson, Eric Schiffhauer, Katarzyna Krysztofiak, Elizabeth Poli, Alexandra Surcel, Darren S. Bryan, Mitchell C. Posner, Michael A. Beckett, Dustin Thomas, Ralph R. Weichselbaum, Alexander T. Pearson, Nikolai N. Khodarev, Lai Xue, Melinda E. Stack, Ronald S. Rock, Urszula Cichoń
Publikováno v:
Proc Natl Acad Sci U S A
Significance There is a pressing need for new approaches to combat metastatic disease. We demonstrate, here, a strategy that targets and activates the molecular machines that control cell shape in cell division, wound healing, immune surveillance, em
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d723d5dff17391dffe5366a91c1f301
https://ruj.uj.edu.pl/xmlui/handle/item/290836
https://ruj.uj.edu.pl/xmlui/handle/item/290836
Autor:
Alexandra Surcel, Douglas N. Robinson
The ability of glioblastoma to disperse through the brain contributes to its lethality, and blocking this behavior has been an appealing therapeutic approach. Although a number of proinvasive signaling pathways are active in glioblastoma, many are re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47af5f130b577f049cedb47a7d55896f
https://europepmc.org/articles/PMC6681748/
https://europepmc.org/articles/PMC6681748/
Autor:
Qingfeng Zhu, Gianfranco Alpini, Bin Guan, Nailing Zhang, Douglas N. Robinson, Ying Liu, Yixin Ren, Tianzhi Luo, Nora E. Joseph, Duojia Pan, Alexandra Surcel, Tian Li Wang, Robert A. Anders, Haibo Bai, Nan Wu
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 311:G396-G411
The Hippo pathway effector Yes-associated protein (YAP) regulates liver size by promoting cell proliferation and inhibiting apoptosis. However, recent in vivo studies suggest that YAP has important cellular functions other than controlling proliferat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbeca6a0c2c947b95c4e48494972c8a
https://doi.org/10.1152/ajpgi.00027.2016
https://doi.org/10.1152/ajpgi.00027.2016
Autor:
Eric Schiffhauer, Oliver Otto, Qingfeng Zhu, Dustin Thomas, Jochen Guck, Kathleen T. DiNapoli, Maik Herbig, Pablo A. Iglesias, Elizabeth M. Jaffee, Douglas N. Robinson, Alexandra Surcel, Robert A. Anders
Metastatic disease is often characterized by altered cellular contractility and deformability, lending cells and groups of cells the flexibility to navigate through different microenvironments. This ability to change cell shape is driven in large par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ed1e4472625bd7537e52196a8dd77d