Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Alexandra Stretton"'
Autor:
Lesley Jones, Peter A. Holmans, Marian L. Hamshere, Denise Harold, Valentina Moskvina, Dobril Ivanov, Andrew Pocklington, Richard Abraham, Paul Hollingworth, Rebecca Sims, Amy Gerrish, Jaspreet Singh Pahwa, Nicola Jones, Alexandra Stretton, Angharad R. Morgan, Simon Lovestone, John Powell, Petroula Proitsi, Michelle K. Lupton, Carol Brayne, David C. Rubinsztein, Michael Gill, Brian Lawlor, Aoibhinn Lynch, Kevin Morgan, Kristelle S. Brown, Peter A. Passmore, David Craig, Bernadette McGuinness, Stephen Todd, Clive Holmes, David Mann, A. David Smith, Seth Love, Patrick G. Kehoe, Simon Mead, Nick Fox, Martin Rossor, John Collinge, Wolfgang Maier, Frank Jessen, Britta Schürmann, Hendrik van den Bussche, Isabella Heuser, Oliver Peters, Johannes Kornhuber, Jens Wiltfang, Martin Dichgans, Lutz Frölich, Harald Hampel, Michael Hüll, Dan Rujescu, Alison M. Goate, John S. K. Kauwe, Carlos Cruchaga, Petra Nowotny, John C. Morris, Kevin Mayo, Gill Livingston, Nicholas J. Bass, Hugh Gurling, Andrew McQuillin, Rhian Gwilliam, Panos Deloukas, Ammar Al-Chalabi, Christopher E. Shaw, Andrew B. Singleton, Rita Guerreiro, Thomas W. Mühleisen, Markus M. Nöthen, Susanne Moebus, Karl-Heinz Jöckel, Norman Klopp, H.-Erich Wichmann, Eckhard Rüther, Minerva M. Carrasquillo, V. Shane Pankratz, Steven G. Younkin, John Hardy, Michael C. O'Donovan, Michael J. Owen, Julie Williams
Publikováno v:
PLoS ONE, Vol 6, Iss 2 (2011)
Externí odkaz:
https://doaj.org/article/a0c75927ea024e6cbe0463ffa3cddcbf
Autor:
Lesley Jones, Peter A Holmans, Marian L Hamshere, Denise Harold, Valentina Moskvina, Dobril Ivanov, Andrew Pocklington, Richard Abraham, Paul Hollingworth, Rebecca Sims, Amy Gerrish, Jaspreet Singh Pahwa, Nicola Jones, Alexandra Stretton, Angharad R Morgan, Simon Lovestone, John Powell, Petroula Proitsi, Michelle K Lupton, Carol Brayne, David C Rubinsztein, Michael Gill, Brian Lawlor, Aoibhinn Lynch, Kevin Morgan, Kristelle S Brown, Peter A Passmore, David Craig, Bernadette McGuinness, Stephen Todd, Clive Holmes, David Mann, A David Smith, Seth Love, Patrick G Kehoe, Simon Mead, Nick Fox, Martin Rossor, John Collinge, Wolfgang Maier, Frank Jessen, Britta Schürmann, Reinhard Heun, Heike Kölsch, Hendrik van den Bussche, Isabella Heuser, Oliver Peters, Johannes Kornhuber, Jens Wiltfang, Martin Dichgans, Lutz Frölich, Harald Hampel, Michael Hüll, Dan Rujescu, Alison M Goate, John S K Kauwe, Carlos Cruchaga, Petra Nowotny, John C Morris, Kevin Mayo, Gill Livingston, Nicholas J Bass, Hugh Gurling, Andrew McQuillin, Rhian Gwilliam, Panos Deloukas, Ammar Al-Chalabi, Christopher E Shaw, Andrew B Singleton, Rita Guerreiro, Thomas W Mühleisen, Markus M Nöthen, Susanne Moebus, Karl-Heinz Jöckel, Norman Klopp, H-Erich Wichmann, Eckhard Rüther, Minerva M Carrasquillo, V Shane Pankratz, Steven G Younkin, John Hardy, Michael C O'Donovan, Michael J Owen, Julie Williams
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e13950 (2010)
BackgroundLate Onset Alzheimer's disease (LOAD) is the leading cause of dementia. Recent large genome-wide association studies (GWAS) identified the first strongly supported LOAD susceptibility genes since the discovery of the involvement of APOE in
Externí odkaz:
https://doaj.org/article/f60141a186cd4676b259fd600531e266
Autor:
Denise Harold, B. McGuiness, Amy Gerrish, David M. A. Mann, Michael Conlon O'Donovan, Petroula Proitsi, Aoibhinn Lynch, Gill Livingston, Simon Mead, Seth Love, John Hardy, Lesley Jones, D. Craig, Peter Holmans, John Powell, Hugh Gurling, David C. Rubinsztein, A. D. Smith, St. Todd, Dobril Ivanov, Sarah Dwyer, Kevin Morgan, N Bass, Kimberley Dowzell, Peter Passmore, J.A. Johnston, Charlene Thomas, Kristelle Brown, Rebecca Sims, John Collinge, Michael Gill, Valentina Moskvina, Brian A. Lawlor, Jaspreet Singh Pahwa, Patrick G. Kehoe, Paul Hollingworth, Clive Holmes, Martin N. Rossor, M. J. Owen, Andrew McQuillin, Michelle K. Lupton, Carol Brayne, Julie Williams, Nick C. Fox, Alexandra Stretton, Simon Lovestone, Jade Chapman, Richard Abraham, Nicola Jones
Publikováno v:
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 156(7), 764-771. Wiley-Liss Inc.
Sims, R, Dwyer, S, Harold, D, Gerrish, A, Hollingworth, P, Chapman, J, Jones, N, Abraham, R, Ivanov, D, Pahwa, J S, Moskvina, V, Dowzell, K, Thomas, C, Stretton, A, Lovestone, S, Powell, J, Proitsi, P, Lupton, M K, Brayne, C, Rubinsztein, D C, Gill, M, Lawlor, B, Lynch, A, Morgan, K, Brown, K S, Passmore, P A, Craig, D, McGuiness, B, Todd, S, Johnston, J A, Holmes, C, Mann, D, Smith, A, Love, S, Kehoe, P G, Hardy, J, Mead, S, Fox, N C, Rossor, M, Collinge, J, Livingston, G, Bass, N J, Gurling, H, McQuillin, A, Jones, L, Holmans, P A, O'Donovan, M, Owen, M J & Williams, J 2011, ' No Evidence that Extended Tracts of Homozygosity are Associated with Alzheimer's Disease ', American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, vol. 156, no. 7, pp. 764-771 . https://doi.org/10.1002/ajmg.b.31216
Sims, R, Dwyer, S, Harold, D, Gerrish, A, Hollingworth, P, Chapman, J, Jones, N, Abraham, R, Ivanov, D, Pahwa, J S, Moskvina, V, Dowzell, K, Thomas, C, Stretton, A, Lovestone, S, Powell, J, Proitsi, P, Lupton, M K, Brayne, C, Rubinsztein, D C, Gill, M, Lawlor, B, Lynch, A, Morgan, K, Brown, K S, Passmore, P A, Craig, D, McGuiness, B, Todd, S, Johnston, J A, Holmes, C, Mann, D, Smith, A, Love, S, Kehoe, P G, Hardy, J, Mead, S, Fox, N C, Rossor, M, Collinge, J, Livingston, G, Bass, N J, Gurling, H, McQuillin, A, Jones, L, Holmans, P A, O'Donovan, M, Owen, M J & Williams, J 2011, ' No Evidence that Extended Tracts of Homozygosity are Associated with Alzheimer's Disease ', American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, vol. 156, no. 7, pp. 764-771 . https://doi.org/10.1002/ajmg.b.31216
We sought to investigate the contribution of extended runs of homozygosity in a genome-wide association dataset of 1,955 Alzheimer's disease cases and 955 elderly screened controls genotyped for 529,205 autosomal single nucleotide polymorphisms. Trac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cea810b109746c7acc809f49cdaec6d
https://doi.org/10.1002/ajmg.b.31216
https://doi.org/10.1002/ajmg.b.31216
Autor:
Neill R. Graff-Radford, Caroline S. Widdowson, John Hardy, Simon Lovestone, Stefan Schreiber, Ana Frank-García, Amy Gerrish, Kevin Mayo, Alexandra Stretton, Michael John Owen, Minerva M. Carrasquillo, Seth Love, Jade Chapman, Vincent Chouraki, Monique M.B. Breteler, Francesco Panza, Emma R L C Vardy, Ronald C. Petersen, Harald Hampel, S. Nicolhaus, Lenore J. Launer, Michelle K. Lupton, Eckart Rüther, A. David Smith, David C. Rubinsztein, Rebecca Sims, Gill Livingston, Diana Zelenika, Simon Mead, Martin N. Rossor, Hilkka Soininen, Christine Van Broeckhoven, Kristel Sleegers, Thorlakur Jonsson, M. Arfan Ikram, Helen Beaumont, Michael Conlon O'Donovan, Federico Licastro, Sudha Seshadri, Alexander Richards, Nick C. Fox, Markus M. Nöthen, Claudine Berr, T. Feulner, Benedetta Nacmias, Carlos Cruchaga, Peter Passmore, Oscar L. Lopez, Julie Williams, Matthias Riemenschneider, Florence Pasquier, John Gallacher, Didier Hannequin, Sigrid Botne Sando, Jens Wiltfang, Charlene Thomas, Gabriele Siciliano, Maria Barcikowska, Mikko Hiltunen, Carol Brayne, Dobril Ivanov, Anita L. DeStefano, Bernadette McGuinness, Norman Klopp, Gordon K. Wilcock, Aoibhinn Lynch, Wolfgang Maier, Peter Holmans, H.-Erich Wichmann, Giorgio Annoni, Beatrice Arosio, Alison Goate, Sigurbjorn Bjornsson, Karl-Heinz Jöckel, Dan Rujescu, Hugh Gurling, Nigel M. Hooper, Clive Holmes, Andrew McQuillin, Patricia Friedrich, John Powell, Rhian Gwilliam, R. Heun, Jacques Epelbaum, Isabella Heuser, Magda Tsolaki, Dennis W. Dickson, Alberto Pilotto, Stephen Todd, Dominique Campion, Michael Krawczak, Jan O. Aasly, Olivier Hanon, Patrick G. Kehoe, Johannes Kornhuber, Marc Delepine, Peter Paul De Deyn, Britta Schürmann, Brian A. Lawlor, Christophe Tzourio, Richard Abraham, Petra Nowotny, Jean-François Dartigues, Heike Kölsch, Michelangelo Mancuso, Marian L. Hamshere, Zbigniew K. Wszolek, Paola Piccardi, Paolo Bosco, Jean-Charles Lambert, Denise Harold, Frank Jessen, Palmi V. Jonsson, Paola Bossù, Paul Hollingworth, Jon Snaedal, Michael Gill, Onofre Combarros, David M. A. Mann, John C. Morris, Annette L. Fitzpatrick, Christopher Shaw, Alexis Brice, Philippe Amouyel, Elio Scarpini, Lesley Jones, Sebastiaan Engelborghs, Daniela Galimberti, Vincenzo Solfrizzi, V. Shane Pankratz, John Collinge, María J. Bullido, Kristelle Brown, Nicholas Bass, Andrew B. Singleton, Jaspreet Singh Pahwa, Kari Stefansson, Lutz Frölich, Steven G. Younkin, Ignacio Mateo, Annick Alpérovitch, Benjamin Genier-Boley, Ina Giegling, Caterina Riehle, Kimberley Dowzell, Mark Lathrop, Hreinn Stefansson, Sandro Sorbi, Rita Guerreiro, Thomas W. Mühleisen, Karolien Bettens, Michael Hüll, Martin Dichgans, Petroula Proitsi, Panagiotis Deloukas, Valentina Moskvina, Cornelia M. van Duijn, Donald Warden, Victoria Alvarez, Eliecer Coto, Kevin Morgan, Susanne Moebus, Ammar Al-Chalabi, Elisa Porcellini, Stefan Wagenpfeil, Hendrik van den Bussche, John S. K. Kauwe, Stacy Steinberg, David Craig, Nicola Jones, Manuel Mayhaus, Davide Seripa
Publikováno v:
Nature genetics 43(5), 429-435 (2011). doi:10.1038/ng.803
Nature Genetics, 43(5), 429-435. Nature Publishing Group
Hollingworth, P, Harold, D, Sims, R, Gerrish, A, Lambert, J-C, Carrasquillo, M M, Abraham, R, Hamshere, M L, Pahwa, J S, Moskvina, V, Dowzell, K, Jones, N, Stretton, A, Thomas, C, Richards, A, Ivanov, D, Widdowson, C, Chapman, J, Lovestone, S, Powell, J, Proitsi, P, Lupton, M K, Brayne, C, Rubinsztein, D C, Gill, M, Lawlor, B, Lynch, A, Brown, K S, Passmore, P A, Craig, D, McGuinness, B, Todd, S, Holmes, C, Mann, D, Smith, A D, Beaumont, H, Warden, D, Wilcock, G, Love, S, Kehoe, P G, Hooper, N M, Vardy, E R L C, Hardy, J, Mead, S, Fox, N C, Rossor, M, Collinge, J, Maier, W, Jessen, F, Ruether, E, Schuermann, B, Heun, R, Koelsch, H, van den Bussche, H, Heuser, I, Kornhuber, J, Wiltfang, J, Dichgans, M, Froelich, L, Hampel, H, Gallacher, J, Huell, M, Rujescu, D, Giegling, I, Goate, A M, Kauwe, J S K, Cruchaga, C, Nowotny, P, Morris, J C, Mayo, K, Sleegers, K, Bettens, K, Engelborghs, S, De Deyn, P P, Van Broeckhoven, C, Livingston, G, Bass, N J, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Al-Chalabi, A, Shaw, C E, Tsolaki, M, Singleton, A B, Guerreiro, R, Muehleisen, T W, Noethen, M M, Moebus, S, Joeckel, K-H, Klopp, N, Wichmann, H-E, Pankratz, V S, Sando, S B, Aasly, J O, Barcikowska, M, Wszolek, Z K, Dickson, D W, Graff-Radford, N R, Petersen, R C, van Duijn, C M, Breteler, M M B, Ikram, M A, DeStefano, A L, Fitzpatrick, A L, Lopez, O, Launer, L J, Seshadri, S, Berr, C, Campion, D, Epelbaum, J, Dartigues, J-F, Tzourio, C, Alperovitch, A, Lathrop, M, Feulner, T M, Friedrich, P, Riehle, C, Krawczak, M, Schreiber, S, Mayhaus, M, Nicolhaus, S, Wagenpfeil, S, Steinberg, S, Stefansson, H, Stefansson, K, Snaedal, J, Bjornsson, S, Jonsson, P V, Chouraki, V, Genier-Boley, B, Hiltunen, M, Soininen, H, Combarros, O, Zelenika, D, Delepine, M, Bullido, M J, Pasquier, F, Mateo, I, Frank-Garcia, A, Porcellini, E, Hanon, O, Coto, E, Alvarez, V, Bosco, P, Siciliano, G, Mancuso, M, Panza, F, Solfrizzi, V, Nacmias, B, Sorbi, S, Bossu, P, Piccardi, P, Arosio, B, Annoni, G, Seripa, D, Pilotto, A, Scarpini, E, Galimberti, D, Brice, A, Hannequin, D, Licastro, F, Jones, L, Holmans, P A, Jonsson, T, Riemenschneider, M, Morgan, K, Younkin, S G, Owen, M J, O'Donovan, M, Amouyel, P & Williams, J 2011, ' Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease ', Nature Genetics, vol. 43, no. 5, pp. 429-435 . https://doi.org/10.1038/ng.803
Nature genetics
Hollingworth, P, Harold, D, Sims, R, Gerrish, A, Lambert, J C, Carrasquillo, M M, Abraham, R, Hamshere, M L, Pahwa, J S, Moskvina, V, Dowzell, K, Jones, N, Stretton, A, Thomas, C, Richards, A, Ivanov, D, Widdowson, C, Chapman, J, Lovestone, S, Powell, J, Proitsi, P, Lupton, M K, Brayne, C, Rubinsztein, D C, Gill, M, Lawlor, B, Lynch, A, Brown, K S, Passmore, P, Craig, D, McGuinness, B, Todd, S, Holmes, C, Mann, D, Smith, A D, Beaumont, H, Warden, D, Wilcock, G, Love, S, Kehoe, P G, Hooper, N M, Vardy, E R L C, Hardy, J, Mead, S, Fox, N C, Rossor, M, Collinge, J, Maier, W, Jessen, F, Ruther, E, Schurmann, B, Heun, R, Kolsch, H, Van Den Bussche, H, Heuser, I, Kornhuber, J, Wiltfang, J, Dichgans, M, Frolich, L, Hampel, H, Gallacher, J, Hull, M, Rujescu, D, Giegling, I, Goate, A M, Kauwe, J S K, Cruchaga, C, Nowotny, P, Morris, J C, Mayo, K, Sleegers, K, Bettens, K, Engelborghs, S, De Deyn, P P, Van Broeckhoven, C, Livingston, G, Bass, N J, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Al-Chalabi, A, Shaw, C E, Tsolaki, M, Singleton, A B, Guerreiro, R, Muhleisen, T W, Nothen, M M, Moebus, S, Jockel, K H, Klopp, N, Wichmann, H E, Pankratz, V S, Sando, S B, Aasly, J O, Barcikowska, M, Wszolek, Z K, Dickson, D W, Graff-Radford, N R, Petersen, R C, Van Duijn, C M, Breteler, M M B, Ikram, M A, DeStefano, A L, Fitzpatrick, A L, Lopez, O, Launer, L J, Seshadri, S, Berr, C, Campion, D, Epelbaum, J, Dartigues, J F, Tzourio, C, Alperovitch, A, Lathrop, M, Feulner, T M, Friedrich, P, Riehle, C, Krawczak, M, Schreiber, S, Mayhaus, M, Nicolhaus, S, Wagenpfeil, S, Steinberg, S, Stefansson, H, Stefansson, K, Snaedal, J, Bjornsson, S, Jonsson, P V, Chouraki, V, Genier-Boley, B, Hiltunen, M, Soininen, H, Combarros, O, Zelenika, D, Delepine, M, Bullido, M J, Pasquier, F, Mateo, I, Frank-Garcia, A, Porcellini, E, Hanon, O, Coto, E, Alvarez, V, Bosco, P, Siciliano, G, Mancuso, M, Panza, F, Solfrizzi, V, Nacmias, B, Sorbi, S, Bossu, P, Piccardi, P, Arosio, B, Annoni, G, Seripa, D, Pilotto, A, Scarpini, E, Galimberti, D, Brice, A, Hannequin, D, Licastro, F, Jones, L, Holmans, P A, Jonsson, T, Riemenschneider, M, Morgan, K, Younkin, S G, Owen, M J, O'Donovan, M, Amouyel, P & Williams, J 2011, ' Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease ', Nature Genetics, vol. 43, no. 5, pp. 429-35 . https://doi.org/10.1038/ng.803
Hollingworth, P, Harold, D, Sims, R, Gerrish, A, Lambert, J C, Carrasquillo, M M, Abraham, R, Hamshere, M L, Pahwa, J S, Moskvina, V, Dowzell, K, Jones, N, Stretton, A, Thomas, C, Richards, A, Ivanov, D, Widdowson, C, Chapman, J, Lovestone, S, Powell, J, Proitsi, P, Lupton, M K, Brayne, C, Rubinsztein, D C, Gill, M, Lawlor, B, Lynch, A, Brown, K S, Passmore, P A, Craig, D, McGuinness, B, Todd, S, Holmes, C, Mann, D, Smith, A D, Beaumont, H, Warden, D, Wilcock, G, Love, S, Kehoe, P G, Hooper, N M, Vardy, E R L C, Hardy, J, Mead, S, Fox, N C, Rossor, M, Collinge, J, Maier, W, Jessen, F, Ruther, E, Schurmann, B, Heun, R, Kolsch, H, van den Bussche, H, Heuser, I, Kornhuber, J, Wiltfang, J, Dichgans, M, Frolich, L, Hampel, H, Gallacher, J, Hull, M, Rujescu, D, Giegling, I, Goate, A M, Kauwe, J S K, Cruchaga, C, Nowotny, P, Morris, J C, Mayo, K, Sleegers, K, Bettens, K, Engelborghs, S, de Deyn, P P, Van Broeckhoven, C, Livingston, G, Bass, N J, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Al-Chalabi, A, Shaw, C E, Tsolaki, M, Singleton, A B, Guerreiro, R, Muhleisen, T W, Nothen, M M, Moebus, S, Jockel, K H, Klopp, N, Wichmann, H E, Pankratz, V S, Sando, S B, Aasly, J O, Barcikowska, M, Wszolek, Z K, Dickson, D W & Graff-Radford, N R A O 2011, ' Common Variants at Abca7, Ms4A6A/Ms4A4E, Epha1, Cd33 and Cd2Ap Are Associated with Alzheimer'S Disease ', Nature Genetics, vol. 43, no. 5, pp. 429-435 . https://doi.org/10.1038/ng.803
Nature Genetics, 43(5), 429-435. Nature Publishing Group
Hollingworth, P, Harold, D, Sims, R, Gerrish, A, Lambert, J-C, Carrasquillo, M M, Abraham, R, Hamshere, M L, Pahwa, J S, Moskvina, V, Dowzell, K, Jones, N, Stretton, A, Thomas, C, Richards, A, Ivanov, D, Widdowson, C, Chapman, J, Lovestone, S, Powell, J, Proitsi, P, Lupton, M K, Brayne, C, Rubinsztein, D C, Gill, M, Lawlor, B, Lynch, A, Brown, K S, Passmore, P A, Craig, D, McGuinness, B, Todd, S, Holmes, C, Mann, D, Smith, A D, Beaumont, H, Warden, D, Wilcock, G, Love, S, Kehoe, P G, Hooper, N M, Vardy, E R L C, Hardy, J, Mead, S, Fox, N C, Rossor, M, Collinge, J, Maier, W, Jessen, F, Ruether, E, Schuermann, B, Heun, R, Koelsch, H, van den Bussche, H, Heuser, I, Kornhuber, J, Wiltfang, J, Dichgans, M, Froelich, L, Hampel, H, Gallacher, J, Huell, M, Rujescu, D, Giegling, I, Goate, A M, Kauwe, J S K, Cruchaga, C, Nowotny, P, Morris, J C, Mayo, K, Sleegers, K, Bettens, K, Engelborghs, S, De Deyn, P P, Van Broeckhoven, C, Livingston, G, Bass, N J, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Al-Chalabi, A, Shaw, C E, Tsolaki, M, Singleton, A B, Guerreiro, R, Muehleisen, T W, Noethen, M M, Moebus, S, Joeckel, K-H, Klopp, N, Wichmann, H-E, Pankratz, V S, Sando, S B, Aasly, J O, Barcikowska, M, Wszolek, Z K, Dickson, D W, Graff-Radford, N R, Petersen, R C, van Duijn, C M, Breteler, M M B, Ikram, M A, DeStefano, A L, Fitzpatrick, A L, Lopez, O, Launer, L J, Seshadri, S, Berr, C, Campion, D, Epelbaum, J, Dartigues, J-F, Tzourio, C, Alperovitch, A, Lathrop, M, Feulner, T M, Friedrich, P, Riehle, C, Krawczak, M, Schreiber, S, Mayhaus, M, Nicolhaus, S, Wagenpfeil, S, Steinberg, S, Stefansson, H, Stefansson, K, Snaedal, J, Bjornsson, S, Jonsson, P V, Chouraki, V, Genier-Boley, B, Hiltunen, M, Soininen, H, Combarros, O, Zelenika, D, Delepine, M, Bullido, M J, Pasquier, F, Mateo, I, Frank-Garcia, A, Porcellini, E, Hanon, O, Coto, E, Alvarez, V, Bosco, P, Siciliano, G, Mancuso, M, Panza, F, Solfrizzi, V, Nacmias, B, Sorbi, S, Bossu, P, Piccardi, P, Arosio, B, Annoni, G, Seripa, D, Pilotto, A, Scarpini, E, Galimberti, D, Brice, A, Hannequin, D, Licastro, F, Jones, L, Holmans, P A, Jonsson, T, Riemenschneider, M, Morgan, K, Younkin, S G, Owen, M J, O'Donovan, M, Amouyel, P & Williams, J 2011, ' Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease ', Nature Genetics, vol. 43, no. 5, pp. 429-435 . https://doi.org/10.1038/ng.803
Nature genetics
Hollingworth, P, Harold, D, Sims, R, Gerrish, A, Lambert, J C, Carrasquillo, M M, Abraham, R, Hamshere, M L, Pahwa, J S, Moskvina, V, Dowzell, K, Jones, N, Stretton, A, Thomas, C, Richards, A, Ivanov, D, Widdowson, C, Chapman, J, Lovestone, S, Powell, J, Proitsi, P, Lupton, M K, Brayne, C, Rubinsztein, D C, Gill, M, Lawlor, B, Lynch, A, Brown, K S, Passmore, P, Craig, D, McGuinness, B, Todd, S, Holmes, C, Mann, D, Smith, A D, Beaumont, H, Warden, D, Wilcock, G, Love, S, Kehoe, P G, Hooper, N M, Vardy, E R L C, Hardy, J, Mead, S, Fox, N C, Rossor, M, Collinge, J, Maier, W, Jessen, F, Ruther, E, Schurmann, B, Heun, R, Kolsch, H, Van Den Bussche, H, Heuser, I, Kornhuber, J, Wiltfang, J, Dichgans, M, Frolich, L, Hampel, H, Gallacher, J, Hull, M, Rujescu, D, Giegling, I, Goate, A M, Kauwe, J S K, Cruchaga, C, Nowotny, P, Morris, J C, Mayo, K, Sleegers, K, Bettens, K, Engelborghs, S, De Deyn, P P, Van Broeckhoven, C, Livingston, G, Bass, N J, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Al-Chalabi, A, Shaw, C E, Tsolaki, M, Singleton, A B, Guerreiro, R, Muhleisen, T W, Nothen, M M, Moebus, S, Jockel, K H, Klopp, N, Wichmann, H E, Pankratz, V S, Sando, S B, Aasly, J O, Barcikowska, M, Wszolek, Z K, Dickson, D W, Graff-Radford, N R, Petersen, R C, Van Duijn, C M, Breteler, M M B, Ikram, M A, DeStefano, A L, Fitzpatrick, A L, Lopez, O, Launer, L J, Seshadri, S, Berr, C, Campion, D, Epelbaum, J, Dartigues, J F, Tzourio, C, Alperovitch, A, Lathrop, M, Feulner, T M, Friedrich, P, Riehle, C, Krawczak, M, Schreiber, S, Mayhaus, M, Nicolhaus, S, Wagenpfeil, S, Steinberg, S, Stefansson, H, Stefansson, K, Snaedal, J, Bjornsson, S, Jonsson, P V, Chouraki, V, Genier-Boley, B, Hiltunen, M, Soininen, H, Combarros, O, Zelenika, D, Delepine, M, Bullido, M J, Pasquier, F, Mateo, I, Frank-Garcia, A, Porcellini, E, Hanon, O, Coto, E, Alvarez, V, Bosco, P, Siciliano, G, Mancuso, M, Panza, F, Solfrizzi, V, Nacmias, B, Sorbi, S, Bossu, P, Piccardi, P, Arosio, B, Annoni, G, Seripa, D, Pilotto, A, Scarpini, E, Galimberti, D, Brice, A, Hannequin, D, Licastro, F, Jones, L, Holmans, P A, Jonsson, T, Riemenschneider, M, Morgan, K, Younkin, S G, Owen, M J, O'Donovan, M, Amouyel, P & Williams, J 2011, ' Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease ', Nature Genetics, vol. 43, no. 5, pp. 429-35 . https://doi.org/10.1038/ng.803
Hollingworth, P, Harold, D, Sims, R, Gerrish, A, Lambert, J C, Carrasquillo, M M, Abraham, R, Hamshere, M L, Pahwa, J S, Moskvina, V, Dowzell, K, Jones, N, Stretton, A, Thomas, C, Richards, A, Ivanov, D, Widdowson, C, Chapman, J, Lovestone, S, Powell, J, Proitsi, P, Lupton, M K, Brayne, C, Rubinsztein, D C, Gill, M, Lawlor, B, Lynch, A, Brown, K S, Passmore, P A, Craig, D, McGuinness, B, Todd, S, Holmes, C, Mann, D, Smith, A D, Beaumont, H, Warden, D, Wilcock, G, Love, S, Kehoe, P G, Hooper, N M, Vardy, E R L C, Hardy, J, Mead, S, Fox, N C, Rossor, M, Collinge, J, Maier, W, Jessen, F, Ruther, E, Schurmann, B, Heun, R, Kolsch, H, van den Bussche, H, Heuser, I, Kornhuber, J, Wiltfang, J, Dichgans, M, Frolich, L, Hampel, H, Gallacher, J, Hull, M, Rujescu, D, Giegling, I, Goate, A M, Kauwe, J S K, Cruchaga, C, Nowotny, P, Morris, J C, Mayo, K, Sleegers, K, Bettens, K, Engelborghs, S, de Deyn, P P, Van Broeckhoven, C, Livingston, G, Bass, N J, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Al-Chalabi, A, Shaw, C E, Tsolaki, M, Singleton, A B, Guerreiro, R, Muhleisen, T W, Nothen, M M, Moebus, S, Jockel, K H, Klopp, N, Wichmann, H E, Pankratz, V S, Sando, S B, Aasly, J O, Barcikowska, M, Wszolek, Z K, Dickson, D W & Graff-Radford, N R A O 2011, ' Common Variants at Abca7, Ms4A6A/Ms4A4E, Epha1, Cd33 and Cd2Ap Are Associated with Alzheimer'S Disease ', Nature Genetics, vol. 43, no. 5, pp. 429-435 . https://doi.org/10.1038/ng.803
We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium (ADGC) in a companion paper. We undertook a combin
Autor:
Nicholas J. Ashton, Claire L. Harris, Simon Lovestone, Alison L. Baird, Mohammed Aiyaz, Abdul Hye, Paul Morgan, Martina Settlecker, Svetlana Hakobyan, Joanna Riddoch-Contreras, Alexandra Stretton, Richard Dobson
Publikováno v:
Alzheimer's & Dementia. 8
Autor:
Nicola Jones, Kevin Morgan, Susanne Moebus, Denise Harold, Ammar Al-Chalabi, David M. A. Mann, Frank Jessen, Ian J. Deary, Clive Holmes, Isabella Heuser, V. Shane Pankratz, Jens Wiltfang, Harald Hampel, John M. Starr, Rebecca Sims, Patrick G. Kehoe, H-Erich Wichmann, Simon Mead, Alison Goate, Aoibhinn Lynch, Michael Conlon O'Donovan, Bernadette McGuinness, Norman Klopp, Janet A. Johnston, Rita Guerreiro, Markus M. Nöthen, Lesley Jones, Hendrik van den Bussche, Reinhard Heun, John S. K. Kauwe, Petra Nowotny, A. David Smith, David Craig, John Powell, Michael Gill, Johannes Kornhuber, Stephen Todd, Seth Love, Thomas W. Mühleisen, Hugh Gurling, Kimberley Dowzell, John C. Morris, Alexander Richards, Marian L. Hamshere, Charlene Thomas, John Collinge, Christopher Shaw, Gill Livingston, Simon Lovestone, Wolfgang Maier, Amy Williams, Lutz Frölich, Jade Chapman, Steven G. Younkin, Karl-Heinz Jöckel, Dobril Ivanov, Brian A. Lawlor, Nick C. Fox, Carlos Cruchaga, Andrew B. Singleton, Gail Davies, Petroula Proitsi, Andrew McQuillin, Michael Hüll, Dan Rujescu, Jaspreet Singh Pahwa, Panagiotis Deloukas, Heike Kölsch, Britta Schürmann, Kevin Mayo, Peter Holmans, Rhian Gwilliam, Magda Tsolaki, Kristelle Brown, Sarah E. Harris, Nicholas Bass, John Hardy, Minerva M. Carrasquillo, Martin N. Rossor, Michael John Owen, Angharad R. Morgan, Paul Hollingworth, Peter Passmore, Giancarlo Russo, Amy Gerrish, Carol Brayne, David C. Rubinsztein, Michelle K. Lupton, Martin Dichgans, Valentina Moskvina, Alexandra Stretton, Richard Abraham, Julie Williams
Publikováno v:
Journal of Alzheimer's Disease, 28(2), 377-387. IOS Press
Gerrish, A, Russo, G, Richards, A, Moskvina, V, Ivanov, D, Harold, D, Sims, R, Abraham, R, Hollingworth, P, Chapman, J, Hamshere, M, Pahwa, J S, Dowzell, K, Williams, A, Jones, N, Thomas, C, Stretton, A, Morgan, A R, Lovestone, S, Powell, J, Proitsi, P, Lupton, M K, Brayne, C, Rubinsztein, D C, Gill, M, Lawlor, B, Lynch, A, Brown, K S, Passmore, P A, Craig, D, McGuinness, B, Todd, S, Johnston, J A, Holmes, C, Mann, D, Smith, A D, Love, S, Kehoe, P G, Hardy, J, Mead, S, Fox, N, Rossor, M, Collinge, J, Maier, W, Jessen, F, Kölsch, H, Heun, R, Schürmann, B, van den Bussche, H, Heuser, I, Kornhuber, J, Wiltfang, J, Dichgans, M, Frölich, L, Hampel, H, Hüll, M, Rujescu, D, Goate, A M, Kauwe, J S K, Cruchaga, C, Nowotny, P, Morris, J C, Mayo, K, Livingston, G, Bass, N J, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Davies, G, Harris, S E, Starr, J M, Deary, I J, Al-Chalabi, A, Shaw, C E, Tsolaki, M, Singleton, A B, Guerreiro, R, Mühleisen, T W, Nöthen, M M, Moebus, S, Jöckel, K-H, Klopp, N, Wichmann, H-E, Carrasquillo, M M, Pankratz, V S, Younkin, S G, Jones, L, Holmans, P A, O'Donovan, M C, Owen, M J, Williams, J & Morgan, K 2012, ' The Role of Variation at AβPP, PSEN1, PSEN2, and MAPT in Late Onset Alzheimer's Disease ' Journal of Alzheimer's disease : JAD, vol 28, no. 2, pp. 377-87 ., 10.3233/JAD-2011-110824
Gerrish, A, Russo, G, Richards, A, Moskvina, V, Ivanov, D, Harold, D, Sims, R, Abraham, R, Hollingworth, P, Chapman, J, Hamshere, M, Pahwa, J S, Dowzell, K, Williams, A, Jones, N, Thomas, C, Stretton, A, Morgan, A R, Lovestone, S, Powell, J, Proitsi, P, Lupton, M K, Brayne, C, Rubinsztein, D C, Gill, M, Lawlor, B, Lynch, A, Morgan, K, Brown, K S, Passmore, P A, Craig, D, McGuinness, B, Todd, S, Johnston, J A, Holmes, C, Mann, D, Smith, A, Love, S, Kehoe, P G, Hardy, J, Mead, S, Fox, N C, Rossor, M, Collinge, J, Maier, W, Jessen, F, Koelsch, H, Heun, R, Schuermann, B, van den Bussche, H, Heuser, I, Kornhuber, J, Wiltfang, J, Dichgans, M, Froelich, L, Hampel, H, Huell, M, Rujescu, D, Goate, A M, Kauwe, J S, Cruchaga, C S, Nowotny, P, Morris, J C, Mayo, K, Livingston, G, Bass, N J, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Davies, G, Harris, S E, Starr, J M, Deary, I J, Al-Chalabi, A, Shaw, C E, Tsolaki, M, Singleton, A B, Guerreiro, R, Muehleisen, T W, Noethen, M M, Moebus, S, Joeckel, K H, Klopp, N, Wichmann, H, Carrasquillo, M M, Pankratz, V, Younkin, S G, Jones, L, Holmans, P A, O'Donovan, M C, Owen, M J & Williams, J 2012, ' The Role of Variation at A beta PP, PSEN1, PSEN2, and MAPT in Late Onset Alzheimer's Disease ', Journal of Alzheimer's Disease, vol. 28, no. 2, pp. 377-387 . https://doi.org/10.3233/JAD-2011-110824
Gerrish, A, Russo, G, Richards, A, Moskvina, V, Ivanov, D, Harold, D, Sims, R, Abraham, R, Hollingworth, P, Chapman, J, Hamshere, M, Pahwa, J S, Dowzell, K, Williams, A, Jones, N, Thomas, C, Stretton, A, Morgan, A R, Lovestone, S, Powell, J, Proitsi, P, Lupton, M K, Brayne, C, Rubinsztein, D C, Gill, M, Lawlor, B, Lynch, A, Morgan, K, Brown, K S, Passmore, P A, Craig, D, McGuinness, B, Todd, S, Johnston, J A, Holmes, C, Mann, D, Smith, A D, Love, S, Kehoe, P G, Hardy, J, Mead, S, Fox, N, Rossor, M, Collinge, J, Maier, W, Jessen, F, Kölsch, H, Heun, R, Schürmann, B, van den Bussche, H, Heuser, I, Kornhuber, J, Wiltfang, J, Dichgans, M, Frölich, L, Hampel, H, Hüll, M, Rujescu, D, Goate, A M, Kauwe, J S K, Cruchaga, C, Nowotny, P, Morris, J C, Mayo, K, Livingston, G, Bass, N J, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Davies, G, Harris, S E, Starr, J M, Deary, I J, Al-Chalabi, A, Shaw, C E, Tsolaki, M, Singleton, A B, Guerreiro, R, Mühleisen, T W, Nöthen, M M, Moebus, S, Jöckel, K-H, Klopp, N, Wichmann, H-E, Carrasquillo, M M, Pankratz, V S, Younkin, S G, Jones, L, Holmans, P A, O'Donovan, M C, Owen, M J & Williams, J 2012, ' The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease ', Journal of Alzheimer's Disease, vol. 28, no. 2, pp. 377-87 . https://doi.org/10.3233/JAD-2011-110824
Gerrish, A, Russo, G, Richards, A, Moskvina, V, Ivanov, D, Harold, D, Sims, R, Abraham, R, Hollingworth, P, Chapman, J, Hamshere, M, Pahwa, J S, Dowzell, K, Williams, A, Jones, N, Thomas, C, Stretton, A, Morgan, A R, Lovestone, S, Powell, J, Proitsi, P, Lupton, M K, Brayne, C, Rubinsztein, D C, Gill, M, Lawlor, B, Lynch, A, Brown, K S, Passmore, P A, Craig, D, McGuinness, B, Todd, S, Johnston, J A, Holmes, C, Mann, D, Smith, A D, Love, S, Kehoe, P G, Hardy, J, Mead, S, Fox, N, Rossor, M, Collinge, J, Maier, W, Jessen, F, Kölsch, H, Heun, R, Schürmann, B, van den Bussche, H, Heuser, I, Kornhuber, J, Wiltfang, J, Dichgans, M, Frölich, L, Hampel, H, Hüll, M, Rujescu, D, Goate, A M, Kauwe, J S K, Cruchaga, C, Nowotny, P, Morris, J C, Mayo, K, Livingston, G, Bass, N J, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Davies, G, Harris, S E, Starr, J M, Deary, I J, Al-Chalabi, A, Shaw, C E, Tsolaki, M, Singleton, A B, Guerreiro, R, Mühleisen, T W, Nöthen, M M, Moebus, S, Jöckel, K-H, Klopp, N, Wichmann, H-E, Carrasquillo, M M, Pankratz, V S, Younkin, S G, Jones, L, Holmans, P A, O'Donovan, M C, Owen, M J, Williams, J & Morgan, K 2012, ' The Role of Variation at AβPP, PSEN1, PSEN2, and MAPT in Late Onset Alzheimer's Disease ' Journal of Alzheimer's disease : JAD, vol 28, no. 2, pp. 377-87 ., 10.3233/JAD-2011-110824
Gerrish, A, Russo, G, Richards, A, Moskvina, V, Ivanov, D, Harold, D, Sims, R, Abraham, R, Hollingworth, P, Chapman, J, Hamshere, M, Pahwa, J S, Dowzell, K, Williams, A, Jones, N, Thomas, C, Stretton, A, Morgan, A R, Lovestone, S, Powell, J, Proitsi, P, Lupton, M K, Brayne, C, Rubinsztein, D C, Gill, M, Lawlor, B, Lynch, A, Morgan, K, Brown, K S, Passmore, P A, Craig, D, McGuinness, B, Todd, S, Johnston, J A, Holmes, C, Mann, D, Smith, A, Love, S, Kehoe, P G, Hardy, J, Mead, S, Fox, N C, Rossor, M, Collinge, J, Maier, W, Jessen, F, Koelsch, H, Heun, R, Schuermann, B, van den Bussche, H, Heuser, I, Kornhuber, J, Wiltfang, J, Dichgans, M, Froelich, L, Hampel, H, Huell, M, Rujescu, D, Goate, A M, Kauwe, J S, Cruchaga, C S, Nowotny, P, Morris, J C, Mayo, K, Livingston, G, Bass, N J, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Davies, G, Harris, S E, Starr, J M, Deary, I J, Al-Chalabi, A, Shaw, C E, Tsolaki, M, Singleton, A B, Guerreiro, R, Muehleisen, T W, Noethen, M M, Moebus, S, Joeckel, K H, Klopp, N, Wichmann, H, Carrasquillo, M M, Pankratz, V, Younkin, S G, Jones, L, Holmans, P A, O'Donovan, M C, Owen, M J & Williams, J 2012, ' The Role of Variation at A beta PP, PSEN1, PSEN2, and MAPT in Late Onset Alzheimer's Disease ', Journal of Alzheimer's Disease, vol. 28, no. 2, pp. 377-387 . https://doi.org/10.3233/JAD-2011-110824
Gerrish, A, Russo, G, Richards, A, Moskvina, V, Ivanov, D, Harold, D, Sims, R, Abraham, R, Hollingworth, P, Chapman, J, Hamshere, M, Pahwa, J S, Dowzell, K, Williams, A, Jones, N, Thomas, C, Stretton, A, Morgan, A R, Lovestone, S, Powell, J, Proitsi, P, Lupton, M K, Brayne, C, Rubinsztein, D C, Gill, M, Lawlor, B, Lynch, A, Morgan, K, Brown, K S, Passmore, P A, Craig, D, McGuinness, B, Todd, S, Johnston, J A, Holmes, C, Mann, D, Smith, A D, Love, S, Kehoe, P G, Hardy, J, Mead, S, Fox, N, Rossor, M, Collinge, J, Maier, W, Jessen, F, Kölsch, H, Heun, R, Schürmann, B, van den Bussche, H, Heuser, I, Kornhuber, J, Wiltfang, J, Dichgans, M, Frölich, L, Hampel, H, Hüll, M, Rujescu, D, Goate, A M, Kauwe, J S K, Cruchaga, C, Nowotny, P, Morris, J C, Mayo, K, Livingston, G, Bass, N J, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Davies, G, Harris, S E, Starr, J M, Deary, I J, Al-Chalabi, A, Shaw, C E, Tsolaki, M, Singleton, A B, Guerreiro, R, Mühleisen, T W, Nöthen, M M, Moebus, S, Jöckel, K-H, Klopp, N, Wichmann, H-E, Carrasquillo, M M, Pankratz, V S, Younkin, S G, Jones, L, Holmans, P A, O'Donovan, M C, Owen, M J & Williams, J 2012, ' The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease ', Journal of Alzheimer's Disease, vol. 28, no. 2, pp. 377-87 . https://doi.org/10.3233/JAD-2011-110824
Rare mutations in AβPP, PSEN1, and PSEN2 cause uncommon early onset forms of Alzheimer's disease (AD), and common variants in MAPT are associated with risk of other neurodegenerative disorders. We sought to establish whether common genetic variation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcfdf3340ebb142a1af8957cb6d1da9b
https://research.vumc.nl/en/publications/782830a0-a77e-430a-99bd-5d174b6edf3e
https://research.vumc.nl/en/publications/782830a0-a77e-430a-99bd-5d174b6edf3e
Autor:
Lambertus Klei, Gill Livingston, Hugh Gurling, Richard Mayeux, Peter Passmore, David Craig, Oscar L. Lopez, Andrew McQuillin, Brian A. Lawlor, Michelle K. Lupton, Bernadette McGuinness, Aoibhinn Lynch, P Priotsi, Denise Harold, N Bass, Paul Hollingworth, Amy Gerrish, Dobril Ivanov, Michael Gill, Kamboh Mi, Lesley Jones, Michael John Owen, F Y Demirci, M. Michael Barmada, Christopher Holmes, Peter Holmans, Rebecca Sims, Nicola L. Jones, Carol Brayne, Bernie Devlin, Simon Lovestone, Valentina Moskvina, Steven T. DeKosky, Giancarlo Russo, Michael Conlon O'Donovan, Robert A. Sweet, Julie Williams, Alexandra Stretton, Jennifer Chapman, Richard Abraham, Janet A. Johnston
Publikováno v:
Hollingworth, P, Sweet, R, Sims, R, Harold, D, Russo, G, Abraham, R, Stretton, A, Jones, N, Gerrish, A, Chapman, J, Ivanov, D, Moskvina, V, Lovestone, S, Priotsi, P, Lupton, M, Brayne, C, Gill, M, Lawlor, B, Lynch, A, Craig, D, McGuinness, B, Johnston, J, Holmes, C, Livingston, G, Bass, N J, Gurling, H, McQuillin, A, Holmans, P, Jones, L, Devlin, B, Klei, L, Barmada, M M, Demirci, F Y, DeKosky, S T, Lopez, O L, Passmore, P, Owen, M J, O'Donovan, M C, Mayeux, R, Kamboh, M I, Williams, J 2012, ' Genome-wide association study of Alzheimer's disease with psychotic symptoms ', Molecular Psychiatry, vol. 17, no. 12, N/A, pp. 1316-1327 . https://doi.org/10.1038/mp.2011.125
Psychotic symptoms occur in similar to 40% of subjects with Alzheimer's disease (AD) and are associated with more rapid cognitive decline and increased functional deficits. They show heritability up to 61% and have been proposed as a marker for a dis
Autor:
Nicola Jones, Paul Hollingworth, Kimberly Dowzell, Julie Williams, Denise Harold, Rebecca Sims, Michael John Owen, Alexandra Stretton, Richard Abraham, Amy Williams
Publikováno v:
Alzheimer's & Dementia. 5
Ângela C. Crespo, Liliana Marques, Erica Marcelino, Carolina Maruta, Sonia Costa, Ângela Timoteo, Frederico Simoes Couto, Ana Herrero, Ana Verdelho, Manuela Guerreiro, Cristina Costa, Alexandre Mendonca, Luciana Costa, Madalena Martins, Instituto G
Autor:
Kimberley Dowzell, Rita Guerreiro, Peter Passmore, Brian A. Lawlor, Isabella Heuser, Frank Jessen, Patrick G. Kehoe, Britta Schürmann, Thomas W. Mühleisen, Charlene Thomas, Lutz Frölich, Steven G. Younkin, John Hardy, Johannes Kornhuber, Peter Paul De Deyn, Minerva M. Carrasquillo, Jens Wiltfang, Michael Hüll, Kristel Sleegers, Alison Goate, Michael Conlon O'Donovan, Petroula Proitsi, Carol Brayne, Markus M. Nöthen, Martin N. Rossor, Marian L. Hamshere, Peter Holmans, Sebastiaan Engelborghs, Amy Gerrish, Panagiotis Deloukas, Hugh Gurling, Denise Harold, Karolien Bettens, Amy L. Williams, Andrew McQuillin, Rhian Gwilliam, David M. A. Mann, Martin Dichgans, Magda Tsolaki, Valentina Moskvina, Wolfgang Maier, Karl-Heinz Jöckel, Gill Livingston, David C. Rubinsztein, H-Erich Wichmann, Simon Lovestone, Hendrik van den Bussche, A. David Smith, Dan Rujescu, John S. K. Kauwe, John Powell, Aoibhinn Lynch, Alexandra Stretton, Nick C. Fox, John Collinge, David Craig, Carlos Cruchaga, Paul Hollingworth, Stephen Todd, Andrew B. Singleton, Nicola L. Jones, Clive Holmes, Jaspreet Singh Pahwa, Petra Nowotny, Michelle K. Lupton, Christopher Shaw, Angharad R. Morgan, Julie Williams, Michael John Owen, Christine Van Broeckhoven, Kevin Mayo, Seth Love, Richard Abraham, Kristelle Brown, Nicholas Bass, V. Shane Pankratz, Kevin Morgan, Susanne Moebus, Ammar Al-Chalabi, Michael Gill, John C. Morris, Harald Hampel, Simon Mead, Bernadette McGuinness, Norman Klopp, Rebecca Sims
Publikováno v:
Harold, D, Abraham, R E, Hollingworth, P, Sims, R, Gerrish, A, Hamshere, M L, Pahwa, J S, Moskvina, V, Dowzell, K, Williams, A G, Jones, N, Thomas, C M, Stretton, A, Morgan, A R, Lovestone, S, Powell, J, Proitsi, P, Lupton, M K, Brayne, C, Rubinsztein, D C, Gill, M, Lawlor, B, Lynch, A, Morgan, K, Brown, K, Passmore, P A, Craig, D, McGuinness, B, Todd, S, Holmes, C, Mann, D, Smith, A D, Love, S, Kehoe, P G, Hardy, J, Mead, S, Fox, N C I, Rossor, M, Collinge, J, Maier, W, Jessen, F, Schurmann, B, van den Bussche, H, Heuser, I, Kornhuber, J, Wiltfang, J, Dichgans, M, Frolich, L, Hampel, H, Hull, M, Rujescu, D, Goate, A M, Kauwe, J S K, Cruchaga, C, Nowotny, P, Morris, J C, Mayo, K, Sleegers, K, Bettens, K, Engelborghs, S, de Deyn, P P, Van Broeckhoven, C, Livingston, G, Shaw, C, Guerreiro, R, Muhleisen, T W, Nothen, M M & Holmans, P A 2009, ' Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease ', Nature Genetics, vol. 41, no. 10, pp. 1088-1093 . https://doi.org/10.1038/ng.440
Harold, D, Abraham, R, Hollingworth, P, Sims, R, Gerrish, A, Hamshere, M L, Pahwa, J S, Moskvina, V, Dowzell, K, Williams, A, Jones, N, Thomas, C, Stretton, A, Morgan, A R, Lovestone, S, Powell, J, Proitsi, P, Lupton, M K, Brayne, C, Rubinsztein, D C, Gill, M, Lawlor, B, Lynch, A, Morgan, K, Brown, K S, Passmore, P A, Craig, D, McGuinness, B, Todd, S, Holmes, C, Mann, D, Smith, A D, Love, S, Kehoe, P G, Hardy, J, Mead, S, Fox, N, Rossor, M, Collinge, J, Maier, W, Jessen, F, Schurmann, B, Van Den Bussche, H, Heuser, I, Kornhuber, J, Wiltfang, J, Dichgans, M, Frolich, L, Hampel, H, Hull, M, Rujescu, D, Goate, A M, Kauwe, J S K, Cruchaga, C, Nowotny, P, Morris, J C, Mayo, K, Sleegers, K, Bettens, K, Engelborghs, S, De Deyn, P P, Van Broeckhoven, C, Livingston, G, Bass, N J, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Al-Chalabi, A, Shaw, C E, Tsolaki, M, Singleton, A B, Guerreiro, R, Muhleisen, T W, Nothen, M M, Moebus, S, Jockel, K H, Klopp, N, Wichmann, H E, Carrasquillo, M M, Pankratz, V S, Younkin, S G, Holmans, P A, O'Donovan, M, Owen, M J & Williams, J 2009, ' Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease ', Nature Genetics, vol. 41, no. 10, pp. 1088-1093 . https://doi.org/10.1038/ng.440
Nature genetics
Harold, D, Abraham, R, Hollingworth, P, Sims, R, Gerrish, A, Hamshere, M L, Pahwa, J S, Moskvina, V, Dowzell, K, Williams, A, Jones, N, Thomas, C, Stretton, A, Morgan, A R, Lovestone, S, Powell, J, Proitsi, P, Lupton, M K, Brayne, C, Rubinsztein, D C, Gill, M, Lawlor, B, Lynch, A, Morgan, K, Brown, K S, Passmore, P A, Craig, D, McGuinness, B, Todd, S, Holmes, C, Mann, D, Smith, A D, Love, S, Kehoe, P G, Hardy, J, Mead, S, Fox, N, Rossor, M, Collinge, J, Maier, W, Jessen, F, Schuermann, B, van den Bussche, H, Heuser, I, Kornhuber, J, Wiltfang, J, Dichgans, M, Froelich, L, Hampel, H, Huell, M, Rujescu, D, Goate, A M, Kauwe, J S K, Cruchaga, C, Nowotny, P, Morris, J C, Mayo, K, Sleegers, K, Bettens, K, Engelborghs, S, De Deyn, P P, Van Broeckhoven, C, Livingston, G, Bass, N J, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Al-Chalabi, A, Shaw, C E, Tsolaki, M, Singleton, A B, Guerreiro, R, Muehleisen, T W, Noethen, M M, Moebus, S, Joeckel, K-H, Klopp, N, Wichmann, H-E, Carrasquillo, M M, Pankratz, V S, Younkin, S G, Holmans, P A, O'Donovan, M, Owen, M J & Williams, J 2009, ' Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease ', Nature Genetics, vol. 41, no. 10, pp. 1088-1093 . https://doi.org/10.1038/ng.440
Nature Genetics, 41(10), 1088-1093. Nature Publishing Group
Harold, D, Abraham, R, Hollingworth, P, Sims, R, Gerrish, A, Hamshere, M L, Pahwa, J S, Moskvina, V, Dowzell, K, Williams, A, Jones, N, Thomas, C, Stretton, A, Morgan, A R, Lovestone, S, Powell, J, Proitsi, P, Lupton, M K, Brayne, C, Rubinsztein, D C, Gill, M, Lawlor, B, Lynch, A, Morgan, K, Brown, K S, Passmore, P A, Craig, D, McGuinness, B, Todd, S, Holmes, C, Mann, D, Smith, A D, Love, S, Kehoe, P G, Hardy, J, Mead, S, Fox, N, Rossor, M, Collinge, J, Maier, W, Jessen, F, Schurmann, B, Van Den Bussche, H, Heuser, I, Kornhuber, J, Wiltfang, J, Dichgans, M, Frolich, L, Hampel, H, Hull, M, Rujescu, D, Goate, A M, Kauwe, J S K, Cruchaga, C, Nowotny, P, Morris, J C, Mayo, K, Sleegers, K, Bettens, K, Engelborghs, S, De Deyn, P P, Van Broeckhoven, C, Livingston, G, Bass, N J, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Al-Chalabi, A, Shaw, C E, Tsolaki, M, Singleton, A B, Guerreiro, R, Muhleisen, T W, Nothen, M M, Moebus, S, Jockel, K H, Klopp, N, Wichmann, H E, Carrasquillo, M M, Pankratz, V S, Younkin, S G, Holmans, P A, O'Donovan, M, Owen, M J & Williams, J 2009, ' Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease ', Nature Genetics, vol. 41, no. 10, pp. 1088-1093 . https://doi.org/10.1038/ng.440
Nature genetics
Harold, D, Abraham, R, Hollingworth, P, Sims, R, Gerrish, A, Hamshere, M L, Pahwa, J S, Moskvina, V, Dowzell, K, Williams, A, Jones, N, Thomas, C, Stretton, A, Morgan, A R, Lovestone, S, Powell, J, Proitsi, P, Lupton, M K, Brayne, C, Rubinsztein, D C, Gill, M, Lawlor, B, Lynch, A, Morgan, K, Brown, K S, Passmore, P A, Craig, D, McGuinness, B, Todd, S, Holmes, C, Mann, D, Smith, A D, Love, S, Kehoe, P G, Hardy, J, Mead, S, Fox, N, Rossor, M, Collinge, J, Maier, W, Jessen, F, Schuermann, B, van den Bussche, H, Heuser, I, Kornhuber, J, Wiltfang, J, Dichgans, M, Froelich, L, Hampel, H, Huell, M, Rujescu, D, Goate, A M, Kauwe, J S K, Cruchaga, C, Nowotny, P, Morris, J C, Mayo, K, Sleegers, K, Bettens, K, Engelborghs, S, De Deyn, P P, Van Broeckhoven, C, Livingston, G, Bass, N J, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Al-Chalabi, A, Shaw, C E, Tsolaki, M, Singleton, A B, Guerreiro, R, Muehleisen, T W, Noethen, M M, Moebus, S, Joeckel, K-H, Klopp, N, Wichmann, H-E, Carrasquillo, M M, Pankratz, V S, Younkin, S G, Holmans, P A, O'Donovan, M, Owen, M J & Williams, J 2009, ' Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease ', Nature Genetics, vol. 41, no. 10, pp. 1088-1093 . https://doi.org/10.1038/ng.440
Nature Genetics, 41(10), 1088-1093. Nature Publishing Group
We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD) involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 cases and 7,848 controls), we replicated the established association wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5f1a22b7285000515ce2180f49422e3
https://research.vumc.nl/en/publications/816af331-3956-4ef6-ad38-2ee70e0b3d59
https://research.vumc.nl/en/publications/816af331-3956-4ef6-ad38-2ee70e0b3d59
Autor:
Marian L. Hamshere, Lyudmila Georgieva, Simon Lovestone, Rebecca Sims, Valentina Moskvina, Hywel T. P. Williams, Carol Brayne, Julie Williams, Nicholas John Craddock, Peter Holmans, George Kirov, Laura Jones, Michael Conlon O'Donovan, Nigel Williams, Alexandra Stretton, Richard Abraham, Michael John Owen, Nadine Norton, Angharad R. Morgan, David C. Rubinsztein, Paul Hollingworth, Ivan Nikolov, Kimberley Dowzell
Publikováno v:
Alzheimer's & Dementia. 4:T599-T600