Výsledky vyhledávání - "Alexandra Stavsky"

Akademický článek

Synapsin E-domain is essential for α-synuclein function

Autor: Alexandra Stavsky, Leonardo A Parra-Rivas, Shani Tal, Jen Riba, Kayalvizhi Madhivanan, Subhojit Roy, Daniel Gitler

Publikováno v: eLife, Vol 12 (2024)

The cytosolic proteins synucleins and synapsins are thought to play cooperative roles in regulating synaptic vesicle (SV) recycling, but mechanistic insight is lacking. Here, we identify the synapsin E-domain as an essential functional binding-partne

Externí odkaz: https://doaj.org/article/54c49400ea3b46eb8987578b70d988d8

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Akademický článek

Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation

Autor: Alexandra Stavsky, Ohad Stoler, Marko Kostic, Tomer Katoshevsky, Essam A. Assali, Ivana Savic, Yael Amitai, Holger Prokisch, Steffen Leiz, Cornelia Daumer-Haas, Ilya Fleidervish, Fabiana Perrochi, Daniel Gitler, Israel Sekler

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)

Stavsky et al. examined the effects of deleting the mitochondrial sodium/lithium/calcium exchanger, NCLX, on mitochondrial and synaptic calcium homeostasis, synaptic activity, and plasticity in mice. Having identified a human mutation that impairs NC

Externí odkaz: https://doaj.org/article/f0e2c7e570da4222b9804930f469cda4

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Akademický článek

ASIC1a senses lactate uptake to regulate metabolism in neurons

Autor: Ivana Savic Azoulay, Xin Qi, Maya Rozenfeld, Fan Liu, Qin Hu, Tsipi Ben Kasus Nissim, Alexandra Stavsky, Michael X. Zhu, Tian-Le Xu, Israel Sekler

Publikováno v: Redox Biology, Vol 51, Iss , Pp 102253- (2022)

Lactate is a major metabolite largely produced by astrocytes that nourishes neurons. ASIC1a, a Na+ and Ca2+-permeable channel with an extracellular proton sensing domain, is thought to be activated by lactate through chelation of divalent cations, in

Externí odkaz: https://doaj.org/article/b926e1d3e12f4f24bca1359d6195ef38

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Akademický článek

Frequency- and spike-timing-dependent mitochondrial Ca2+ signaling regulates the metabolic rate and synaptic efficacy in cortical neurons

Autor: Ohad Stoler, Alexandra Stavsky, Yana Khrapunsky, Israel Melamed, Grace Stutzmann, Daniel Gitler, Israel Sekler, Ilya Fleidervish

Publikováno v: eLife, Vol 11 (2022)

Mitochondrial activity is crucial for the plasticity of central synapses, but how the firing pattern of pre- and postsynaptic neurons affects the mitochondria remains elusive. We recorded changes in the fluorescence of cytosolic and mitochondrial Ca2

Externí odkaz: https://doaj.org/article/fa37d91590f94efc99cae25f5be82c10

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Akademický článek

Author Correction: Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-1 (2021)

Externí odkaz: https://doaj.org/article/71dbc48b81ff44bf90112ee9c7bd576d

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Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation

Autor: Tomer Katoshevsky, Fabiana Perocchi, Daniel Gitler, Essam A. Assali, Steffen Leiz, Ohad Stoler, Marko Kostic, Yael Amitai, Ilya A. Fleidervish, Ivana Savic, Israel Sekler, Alexandra Stavsky, Holger Prokisch, Cornelia Daumer-Haas

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Comm. Biol. 4:666 (2021)
Communications Biology

Calcium dynamics control synaptic transmission. Calcium triggers synaptic vesicle fusion, determines release probability, modulates vesicle recycling, participates in long-term plasticity and regulates cellular metabolism. Mitochondria, the main sour

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec6316a6104080ac30a0dec91fec8d4d
https://doaj.org/article/f0e2c7e570da4222b9804930f469cda4

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