Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Alexandra Sposny"'
Autor:
Stephen R. Pennington, Ronald L. Woodbury, Diane McCarthy, Alexandra Sposny, Arnd Brandenburg, William M. Gallagher, Ben C. Collins, Phillip Hewitt, Jean-Charles Gautier
Publikováno v:
Collins, B C, Sposny, A, McCarthy, D, Brandenburg, A, Woodbury, R, Pennington, S R, Gautier, J-C, Hewitt, P & Gallagher, W M 2010, ' Use of SELDI MS to discover and identify potential biomarkers of toxicity in InnoMed PredTox: A multi-site, multi-compound study ', Proteomics, vol. 10, no. 8, pp. 1592-1608 . https://doi.org/10.1002/pmic.200900608
A serious bottleneck in the drug development pipeline is the inability of current pre-clinical toxicology evaluation methods to predict early on, and with good accuracy, that a drug candidate will have to be removed from development due to toxicology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cdda43d1d70d0e09d931d1bd390145f
https://doi.org/10.1002/pmic.200900608
https://doi.org/10.1002/pmic.200900608
Autor:
William M. Gallagher, Stephen R. Pennington, Martin Wells, Phillip Hewitt, Ben C. Collins, Christine A. Miller, Alexandra Sposny
Publikováno v:
Collins, B C, Miller, C A, Sposny, A, Hewitt, P, Wells, M, Gallagher, W M & Pennington, S R 2012, ' Development of a Pharmaceutical Hepatotoxicity Biomarker Panel Using a Discovery to Targeted Proteomics Approach ', Molecular and Cellular Proteomics, vol. 11, no. 8, pp. 394-410 . https://doi.org/10.1074/mcp.M111.016493
There is a pressing and continued need for improved predictive power in preclinical pharmaceutical toxicology assessment as substantial numbers of drugs are still removed from the market, or from late-stage development, because of unanticipated issue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df2ba31c07de37df7fc00cb6198fd54
https://pubmed.ncbi.nlm.nih.gov/22527513
https://pubmed.ncbi.nlm.nih.gov/22527513
Autor:
Alexandra, Sposny, Philip G, Hewitt
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 818
Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) has become a popular method for protein profiling in clinical diagnosis, as well as in toxicological studies. It combines solid-phase chromatography with TOF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fd5d9ff6ba1b67449b7252f65f488a73
https://pubmed.ncbi.nlm.nih.gov/22083820
https://pubmed.ncbi.nlm.nih.gov/22083820
Autor:
Philip G. Hewitt, Alexandra Sposny
Publikováno v:
Methods in Molecular Biology ISBN: 9781617794179
Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) has become a popular method for protein profiling in clinical diagnosis, as well as in toxicological studies. It combines solid-phase chromatography with TOF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b5a9d8414f2dd64bf755d229f672397
https://doi.org/10.1007/978-1-61779-418-6_9
https://doi.org/10.1007/978-1-61779-418-6_9
Publikováno v:
General, Applied and Systems Toxicology
We have used modern omics technologies (including Toxicogenomics, proteomics, metabonomics and profiling from FFPE tissues) to ascertain whether a systems biology approach would improve our understanding of the mechanism of toxicity of a compound. Wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db474446793c1c3e4b4bf641e5eda667
https://doi.org/10.1002/9780470744307.gat224
https://doi.org/10.1002/9780470744307.gat224
Autor:
Heidrun Ellinger-Ziegelbauer, Brian C. Sweatman, John J. Callanan, Marian Raschke, Mark P. Hodson, Angela Mally, Arnd Brandenburg, Katja Matheis, Alexandra Sposny, Hans Gmuender, Diane McCarthy, Laura Suter, Björn Riefke, Albrecht Gruhler, Susan C. Connor, Alexander Amberg, Christina S. Schmitt, Max Sieber, Melanie Adler, Michael Fountoulakis, Philip Hewitt
Publikováno v:
Toxicology and applied pharmacology. 252(2)
The InnoMed PredTox consortium was formed to evaluate whether conventional preclinical safety assessment can be significantly enhanced by incorporation of molecular profiling (" omics" ) technologies. In short-term toxicological studies in rats, tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edd87394ca49ddc10b9fd3bc2f53ff95
https://pubmed.ncbi.nlm.nih.gov/20888850
https://pubmed.ncbi.nlm.nih.gov/20888850
Autor:
John J. Callanan, Heidrun Ellinger-Ziegelbauer, Arnd Brandenburg, Melanie Adler, William M. Gallagher, Katja Matheis, Alexandra Sposny, Joseph V. Bonventre, Frank Dieterle, Wolfgang Dekant, Frank Staedtler, Dana Hoffmann, Vishal S. Vaidya, Jean C. Gautier, Eva Rached, Angela Mally, Philip G. Hewitt, Laoighse Mulrane
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 116(1)
The kidney is one of the main targets of drug toxicity, but early detection of renal damage is often difficult. As part of the InnoMed PredTox project, a collaborative effort aimed at assessing the value of combining omics technologies with conventio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d117aa1aeacdc7146df5a208febeccdd
https://pubmed.ncbi.nlm.nih.gov/20118187
https://pubmed.ncbi.nlm.nih.gov/20118187
Autor:
Bjoern Riefke, Olaf Boernson, Katja Matheis, Alexander Amberg, Emmanuelle Com, Frank Dieterle, Dana Hoffmann, Hans Gmuender, Alexandra Sposny, Frank Staedtler, Arno Kalkuhl, Angela Mally, Arnd Brandenburg, Jean-Charles Gautier
Publikováno v:
Toxicology Letters. 189:S91
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b021d2a3f7cfb708d9dfb4e0214e2253
https://doi.org/10.1016/j.toxlet.2009.06.274
https://doi.org/10.1016/j.toxlet.2009.06.274