Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Alexandra Sontheimer"'
Autor:
Alexandra Sontheimer-Phelps, David B. Chou, Alessio Tovaglieri, Thomas C. Ferrante, Taylor Duckworth, Cicely Fadel, Viktoras Frismantas, Arlene D. Sutherland, Sasan Jalili-Firoozinezhad, Magdalena Kasendra, Eric Stas, James C. Weaver, Camilla A. Richmond, Oren Levy, Rachelle Prantil-Baun, David T. Breault, Donald E. Ingber
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 3, Pp 507-526 (2020)
Background & Aims: The mucus layer in the human colon protects against commensal bacteria and pathogens, and defects in its unique bilayered structure contribute to intestinal disorders, such as ulcerative colitis. However, our understanding of colon
Externí odkaz:
https://doaj.org/article/554b633ff25042a892b30b69e190d4cd
Autor:
Alessio Tovaglieri, Alexandra Sontheimer-Phelps, Annelies Geirnaert, Rachelle Prantil-Baun, Diogo M. Camacho, David B. Chou, Sasan Jalili-Firoozinezhad, Tomás de Wouters, Magdalena Kasendra, Michael Super, Mark J. Cartwright, Camilla A. Richmond, David T. Breault, Christophe Lacroix, Donald E. Ingber
Publikováno v:
Microbiome, Vol 7, Iss 1, Pp 1-21 (2019)
Abstract Background Species-specific differences in tolerance to infection are exemplified by the high susceptibility of humans to enterohemorrhagic Escherichia coli (EHEC) infection, whereas mice are relatively resistant to this pathogen. This intri
Externí odkaz:
https://doaj.org/article/76b721f3cb93444bb33fc22d0b887943
Autor:
Amir Bein, Woojung Shin, Sasan Jalili-Firoozinezhad, Min Hee Park, Alexandra Sontheimer-Phelps, Alessio Tovaglieri, Angeliki Chalkiadaki, Hyun Jung Kim, Donald E. Ingber
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 4, Pp 659-668 (2018)
Microfluidic organ-on-a-chip models of human intestine have been developed and used to study intestinal physiology and pathophysiology. In this article, we review this field and describe how microfluidic Intestine Chips offer new capabilities not pos
Externí odkaz:
https://doaj.org/article/1649e018d954403a9bd7246603660a8c
Autor:
Bryan A. Hassell, Girija Goyal, Esak Lee, Alexandra Sontheimer-Phelps, Oren Levy, Christopher S. Chen, Donald E. Ingber
Publikováno v:
Cell Reports, Vol 21, Iss 2, Pp 508-516 (2017)
Summary: Here, we show that microfluidic organ-on-a-chip (organ chip) cell culture technology can be used to create in vitro human orthotopic models of non-small-cell lung cancer (NSCLC) that recapitulate organ microenvironment-specific cancer growth
Externí odkaz:
https://doaj.org/article/31caf4f495074ab288431229b2f9c547
Autor:
Junpei Yamaguchi, Andrew S. Liss, Alexandra Sontheimer, Mari Mino-Kenudson, Carlos Fernández-del Castillo, Andrew L. Warshaw, Sarah P. Thayer
Publikováno v:
Stem Cell Research, Vol 15, Iss 1, Pp 190-202 (2015)
Pancreatic duct glands (PDGs) have molecular features known to mark stem cell niches, but their function remains to be determined. To investigate the role of PDGs as a progenitor niche, PDGs were analyzed in both humans and mice. Cells were character
Externí odkaz:
https://doaj.org/article/ccd2aa3f97f54192a882e309ffe78903
Autor:
Barbara B. Kahn, Mark M. Yore, Angela Castoldi, Julie Norseen, Kotryna Simonyté Sjödin, Pedro M. Moraes-Vieira, Pratik Aryal, Alexandra Sontheimer-Phelps
Publikováno v:
Proc Natl Acad Sci U S A
Adipose tissue (AT) inflammation contributes to systemic insulin resistance. In obesity and type 2 diabetes (T2D), retinol binding protein 4 (RBP4), the major retinol carrier in serum, is elevated in AT and has proinflammatory effects which are media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb480c9b20fccd776c2bf1474f8937f3
https://doi.org/10.1073/pnas.2013877117
https://doi.org/10.1073/pnas.2013877117
Autor:
Anna Herland, Ben Swenor, Daniel Levner, Olivier Y.F. Henry, Sasan Jalili-Firoozinezhad, Angeliki Chalkiadaki, Henry Sanchez, Andrzej Przekwas, Sauveur S. F. Jeanty, Rachelle Prantil-Baun, Josiah Sliz, Youngjae Choe, Kyung-Jin Jang, Moran Yadid, Susan Marquez, Chris Hinojosa, Thomas C. Ferrante, Blakely B. O'Connor, Tiama Hamkins-Indik, Rachel Fleming, Stephanie Dauth, Janna Nawroth, Morgan Burt, Ben M. Maoz, David B. Chou, Aaron Delahanty, John P. Ferrier, Anthony Bahinski, Jose Fernandez-Alcon, Bret Nestor, Guy Robert Thompson, Lian Leng, Robert Mannix, Michael J. Cronce, Yuka Milton, Mahadevabharath R. Somayaji, Alexandra Sontheimer-Phelps, Tae-Eun Park, Miles Ingram, Edward A. FitzGerald, Debarun Das, Ville J. Kujala, Josue A. Goss, George J. Touloumes, Toni Divic, Carlos F. Ng, Oren Levy, Zachary Tranchemontagne, Elizabeth Calamari, Geraldine A. Hamilton, Alexander Cho, Thomas Grevesse, Norman Wen, Tessa Huffstater, Donald E. Ingber, Kevin Kit Parker, Richard M. Novak
Publikováno v:
Nature Biomedical Engineering. 4:407-420
Organ chips can recapitulate organ-level (patho)physiology, yet pharmacokinetic and pharmacodynamic analyses require multi-organ systems linked by vascular perfusion. Here, we describe an 'interrogator' that employs liquid-handling robotics, custom s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea94accc104e59d5af0303d98dc1c94f
https://doi.org/10.1038/s41551-019-0497-x
https://doi.org/10.1038/s41551-019-0497-x
Autor:
David B. Chou, Rachelle Prantil-Baun, Ben Swenor, Sasan Jalili-Firoozinezhad, Andrzej Przekwas, Susan Marquez, Tessa Huffstater, Donald E. Ingber, Ben M. Maoz, Anna Herland, Michael J. Cronce, Yuka Milton, Angeliki Chalkiadaki, Miles Ingram, Mahadevabharath R. Somayaji, Alexandra Sontheimer-Phelps, Oren Levy, Sauveur S. F. Jeanty, Richard M. Novak, Aaron Delahanty, Kevin Kit Parker, Debarun Das
Publikováno v:
Nature Biomedical Engineering. 4:421-436
Analyses of drug pharmacokinetics (PKs) and pharmacodynamics (PDs) performed in animals are often not predictive of drug PKs and PDs in humans, and in vitro PK and PD modelling does not provide quantitative PK parameters. Here, we show that physiolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ec82bf12b83e9e3677dba09ab7cdb54
https://doi.org/10.1038/s41551-019-0498-9
https://doi.org/10.1038/s41551-019-0498-9
Autor:
Thomas C. Ferrante, Viktoras Frismantas, Donald E. Ingber, David T. Breault, Sasan Jalili-Firoozinezhad, David B. Chou, Cicely Fadel, Magdalena Kasendra, James C. Weaver, Eric Stas, Rachelle Prantil-Baun, Oren Levy, Camilla A. Richmond, Alexandra Sontheimer-Phelps, Arlene D. Sutherland, Taylor Duckworth, Alessio Tovaglieri
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 3, Pp 507-526 (2020)
Background & Aims: The mucus layer in the human colon protects against commensal bacteria and pathogens, and defects in its unique bilayered structure contribute to intestinal disorders, such as ulcerative colitis. However, our understanding of colon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9771646a41f9111333a9cd11e0ed2d
http://www.sciencedirect.com/science/article/pii/S2352345X19301638
http://www.sciencedirect.com/science/article/pii/S2352345X19301638
Autor:
Zohreh, Izadifar, Alexandra, Sontheimer-Phelps, Bob A, Lubamba, Haiqing, Bai, Cicely, Fadel, Anna, Stejskalova, Alican, Ozkan, Queeny, Dasgupta, Amir, Bein, Abidemi, Junaid, Aakanksha, Gulati, Gautam, Mahajan, Seongmin, Kim, Nina T, LoGrande, Arash, Naziripour, Donald E, Ingber
Publikováno v:
Advanced Drug Delivery Reviews. 191:114542
The surfaces of human internal organs are lined by a mucus layer that ensures symbiotic relationships with commensal microbiome while protecting against potentially injurious environmental chemicals, toxins, and pathogens, and disruption of this laye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8455b1ad272c592b43b7792dd1e84c
https://doi.org/10.1016/j.addr.2022.114542
https://doi.org/10.1016/j.addr.2022.114542