Výsledky vyhledávání - "Alexandra Sipol"

MondoA drives malignancy in B-ALL through enhanced adaptation to metabolic stress

Publikováno v: Sipol, A, Hameister, E, Xue, B, Hofstetter, J, Barenboim, M, Öllinger, R, Jain, G, Prexler, C, Rubio, R A, Baldauf, M C, Franchina, D G, Petry, A, Schmäh, J, Thiel, U, Görlach, A, Cario, G, Brenner, D, Richter, G H S, Grünewald, T G P, Rad, R, Wolf, E, Ruland, J, Sorensen, P H & Burdach, S E G 2022, ' MondoA drives malignancy in B-ALL through enhanced adaptation to metabolic stress ', Blood, vol. 139, no. 8, pp. 1184-1197 . https://doi.org/10.1182/blood.2020007932

Cancer cells are in most instances characterized by rapid proliferation and uncontrolled cell division. Hence, they must adapt to proliferation-induced metabolic stress through intrinsic or acquired antimetabolic stress responses to maintain homeosta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e550109e1f81b852e1a097e196ce3e
https://doi.org/10.1182/blood.2020007932

Zobrazit plný text záznamu

The Truncated Splice Variant of the Granulocyte-Macrophage-Colony-Stimulating Factor Receptor β- Chain in Peripheral Blood Serves as Severity Biomarker of Respiratory Failure in Newborns

Autor: Alexandra Sipol, Verena Schulte, Esther Rieger-Fackeldey, Stefan Burdach

Publikováno v: Neonatology

Background: The granulocyte-macrophage-colony-stimulating factor (GM-CSF) plays an important role in surfactant homeostasis. βC is a subunit of the GM-CSF receptor (GM-CSF-R), and its activation mediates surfactant catabolism in the lung. βIT is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957433361c9dfcb1e200ae9212d3009f
https://doi.org/10.1159/000513356

Zobrazit plný text záznamu

Abstract B51: Adaptation to oncogene-induced metabolic stress by MondoA (MLXIP) drives common acute lymphoblastic leukemia (cALL) malignancy

Autor: Agnes Görlach, Erik Hameister, Andreas Petry, Alexandra Sipol, Poul H. Sorensen, Stefan Burdach, Jürgen Ruland, Guenther H. S. Richter

Publikováno v: Cancer Research. 80:B51-B51

MondoA (also known as MLXIP, MAX-like protein X interacting protein) is a metabolic stress sensor and a proglycolytic transcription factor potentially involved in metabolic addiction features of leukemia and the Warburg effect. MondoA dimerizes with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd29b4b8384b6282cec501f24d8b5491
https://doi.org/10.1158/1538-7445.pedca19-b51

Zobrazit plný text záznamu

Abstract 4515: Metabolic stress sensor MondoA mediates in vivo aggressiveness of common ALL by induction of HIF1α

Autor: Thomas G. P. Grunewald, Stefan Burdach, Gunnar Cario, Martin A. Horstmann, Caroline M. Wernicke, Gunther Richter, Alexandra Sipol, Michaela C. Baldauf, Monique L. den Boer, Juliane Schmaeh, Rebeca Alba Rubio

Publikováno v: Cancer Research. 77:4515-4515

Tumor cells evolve adaptive mechanisms to survive hypoxia, nutrient deprivation, oxidative or genotoxic stress to ultimately drive tumor progression (Sorensen et al. 2015). We previously described MondoA (also known as MLXIP, MAX like protein X inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66be674b40d98ef7fd10fa2de918f5ad
https://doi.org/10.1158/1538-7445.am2017-4515

Zobrazit plný text záznamu

Abstract 2462: MondoA mediates in vivo aggressiveness of common ALL and may serve as a T-cell immunotherapy target

Autor: Gunnar Cario, David Schirmer, Michaela C. Baldauf, Juliane Schmaeh, Hans-Jochem Kolb, Caroline M. Wernicke, Guünther Richter, Alexandra Sipol, Monique L. den Boer, Stefan Burdach, Rebeca Alba Rubio, Thomas G. P. Grunewald, Martin A. Horstmann

Publikováno v: Cancer Research. 76:2462-2462

Oncogene addiction provides ideal targets for immunotherapy. We previously described MondoA (also known as MLXIP, MAX like protein X interacting protein) as a metabolic stress sensor, required for leukemogenesis. Here we report on the expression of M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90aef866246555a9443968ace8fada3e
https://doi.org/10.1158/1538-7445.am2016-2462

Zobrazit plný text záznamu

Overexpression of the Metabolic Stress Sensor and Proglycolytic Transcription Factor ΜLΧΙΡ Mediates Malignancy of Common Acute Lymphoblastic Leukemia in Vivo and Is Targetable By Allorestricted Peptide Specific T Cells

Autor: Hans-Jochem Kolb, Torsten Haferlach, Thomas G. P. Grunewald, Stefan Burdach, Guenther H. S. Richter, Caroline M. Wernicke, Alexandra Sipol

Publikováno v: Blood. 124:2436-2436

Oncogene addiction provides ideal targets for successful immunotherapy. MLXIP (MAX like protein X interacting protein, also known as MondoA) is a metabolic stress sensor and a proglycolytic transcription factor potentially involved in metabolic addic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2233de49c59e65a3738bd1afc1312b4e
https://doi.org/10.1182/blood.v124.21.2436.2436

Zobrazit plný text záznamu

Abstract 1421: Overexpression of the pro-glycolytic transcription factor MondoA enhances malignant potential of ALL in vivo

Autor: Alexandra Sipol, Gunther Richter, Caroline M. Wernicke, Stefan Burdach, Thomas G. P. Grunewald

Publikováno v: Cancer Research. 74:1421-1421

Introduction. Most cancer cells use glycolysis for energy production regardless of whether they are under normoxic or hypoxic condition (Koppenol et al., 2011). Warburg described this metabolic hallmark of cancer cells, named aerobic glycolysis. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e3341825fe5ab7a6839b53004440469
https://doi.org/10.1158/1538-7445.am2014-1421

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání