Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Alexandra Sharland"'
Autor:
Indu G. Rajapaksha, Lakmie S. Gunarathne, Khashayar Asadi, Sharon C. Cunningham, Alexandra Sharland, Ian E. Alexander, Peter W. Angus, Chandana B. Herath
Publikováno v:
Hepatology Communications, Vol 3, Iss 12, Pp 1656-1673 (2019)
There is a large unmet need for effective therapies for cholestatic disorders, including primary sclerosing cholangitis (PSC), a disease that commonly results in liver failure. Angiotensin (Ang) II of the renin Ang system (RAS) is a potent profibroti
Externí odkaz:
https://doaj.org/article/6d5408cffc4642cfa702001e7df903ec
Autor:
Nirupama D. Verma, Catherine M. Robinson, Nicole Carter, Paul Wilcox, Giang T. Tran, Chaunmin Wang, Alexandra Sharland, Masaru Nomura, Karren M. Plain, G. Alexander Bishop, Suzanne J. Hodgkinson, Bruce M. Hall
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Therapy with alloantigen-specific CD4+CD25+ T regulatory cells (Treg) for induction of transplant tolerance is desirable, as naïve thymic Treg (tTreg) are not alloantigen-specific and are weak suppressor cells. Naïve tTreg from DA rats cultured wit
Externí odkaz:
https://doaj.org/article/80a584ad7fdd4a2d8602aba5e8068f8a
Autor:
Belal Chami, Farjaneh Hossain, Thomas W. Hambly, Xiaoping Cai, Roshanak Aran, Genevieve Fong, Abigail Vellajo, Nathan J.J Martin, XiaoSuo Wang, Joanne M. Dennis, Arpeeta Sharma, Waled A. Shihata, Jaye P. F. Chin-Dusting, Judy B. de Haan, Alexandra Sharland, Carolyn L. Geczy, Ben Freedman, Paul K. Witting
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Elevated serum amyloid A (SAA) levels may promote endothelial dysfunction, which is linked to cardiovascular and renal pathologies. We investigated the effect of SAA on vascular and renal function in apolipoprotein E-deficient (ApoE−/−) mice. Mal
Externí odkaz:
https://doaj.org/article/3257a71d9f64427bad0e208aaa82518f
Autor:
Belal Chami, Nicola Barrie, Xiaoping Cai, Xiaosuo Wang, Moumita Paul, Rebecca Morton-Chandra, Alexandra Sharland, Joanne M. Dennis, Saul B. Freedman, Paul K. Witting
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 5, Pp 11101-11124 (2015)
The acute phase protein serum amyloid A (SAA), a marker of inflammation, induces expression of pro-inflammatory and pro-thrombotic mediators including ICAM-1, VCAM-1, IL-6, IL-8, MCP-1 and tissue factor (TF) in both monocytes/macrophages and endothel
Externí odkaz:
https://doaj.org/article/3f492455b5f448c6978cf7abe45d48b6
Autor:
Moumita Paul-Heng, Martina Denkova, Eric Taeyoung Son, Thomas Ashhurst, Mario Leong, Claerwen Jones, Pirooz Zareie, Anthony Purcell, Nicole L La Gruta, Nicole Mifsud, Alexandra Sharland
Publikováno v:
Transplantation. 106:S483-S484
Autor:
Bruce Milne Hall, Nirupama Darshan Verma, Catherine Margaret Robinson, Chaunmin Wang, Alexandra Sharland, Giang Tran, Paul Wilcox, Suzanne Jean Hodgkinson
Publikováno v:
The Journal of Immunology. 202:57.20-57.20
Therapy with antigen-specific CD4+CD25+ T regulatory cells (Treg) for induction of transplant tolerance is desirable, as naïve thymic Treg (tTreg) are non-antigen specific and weak suppressor cells. Naïve tTreg from DA rats cultured with fully allo
Autor:
Bruce Milne Hall, Prateek Rakesh, Giang Tran, Rachael Hall, Sukandeep Bedi, Catherine Margaret Robinson, Alexandra Sharland, Chaunmin Wang, Suzanne Jean Hodgkinson, Nirupama Darshan Verma
Publikováno v:
The Journal of Immunology. 202:186.11-186.11
Naïve CD4+CD25+Foxp3+T regulatory cells (tTreg) activated by specific alloantigen (Ag) and IL-4 express IL-5Ralpha. We examined if IL-5 treatment activated alloAg specific Treg to prevent chronic rejection in F344 rats grafted with Lewis hearts. 500
Publikováno v:
Transplantation. 76:1615-1622
Background. CD56 + human natural killer (NK) cells are the principal anti-pig cytotoxic effectors in vitro. Expression of certain human leukocyte antigen (HLA) class I molecules in porcine cells can inhibit NK cell-mediated natural cytotoxicity in se
Publikováno v:
Discovery medicine. 9(49)
Vectors based on recombinant adeno-associated virus (AAV) 2/8 hold considerable promise for use in human gene therapy. These vectors are safe, and have minimal immunostimulatory properties. Their combination with efficient, liver-specific promoters a
Publikováno v:
Transplantation. 76(11)
CD56+ human natural killer (NK) cells are the principal anti-pig cytotoxic effectors in vitro. Expression of certain human leukocyte antigen (HLA) class I molecules in porcine cells can inhibit NK cell-mediated natural cytotoxicity in serum-free medi