Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Alexandra Sexton"'
Understanding the biological processes of kidney carcinogenesis: an integrative multi-omics approach
Autor:
Ricardo Cortez Cardoso Penha, Alexandra Sexton Oates, Sergey Senkin, Hanla A Park, Joshua Atkins, Ivana Holcatova, Anna Hornakova, Slavisa Savic, Simona Ognjanovic, Beata Świątkowska, Jolanta Lissowska, David Zaridze, Anush Mukeria, Vladimir Janout, Amelie Chabrier, Vincent Cahais, Cyrille Cuenin, Ghislaine Scelo, Matthieu Foll, Zdenko Herceg, Paul Brennan, Karl Smith-Byrne, Nicolas Alcala, James D Mckay
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 12, Pp 1282-1302 (2024)
Abstract Biological mechanisms related to cancer development can leave distinct molecular fingerprints in tumours. By leveraging multi-omics and epidemiological information, we can unveil relationships between carcinogenesis processes that would othe
Externí odkaz:
https://doaj.org/article/a826898908c949ca9476ef69f644d069
Autor:
Boris Novakovic, Sharon Lewis, Jane Halliday, Joanne Kennedy, David P. Burgner, Anna Czajko, Bowon Kim, Alexandra Sexton-Oates, Markus Juonala, Karin Hammarberg, David J. Amor, Lex W. Doyle, Sarath Ranganathan, Liam Welsh, Michael Cheung, John McBain, Robert McLachlan, Richard Saffery
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Use of Assisted Reproductive Technologies (ART) is increasing globally but their impact on long term health remains unclear. Here the authors show that ART-conceived individuals show variation in epigenetic profile at birth that largely resolves by a
Externí odkaz:
https://doaj.org/article/a001b8f17ce14b76a01653102a7348a0
Autor:
Laura S. Bleker, Jeannette Milgrom, Alexandra Sexton-Oates, Tessa J. Roseboom, Alan W. Gemmill, Christopher J. Holt, Richard Saffery, Huibert Burger, Susanne R. de Rooij
Publikováno v:
Clinical Epigenetics, Vol 11, Iss 1, Pp 1-24 (2019)
Abstract Background Children prenatally exposed to maternal depression more often show behavioral and emotional problems compared to unexposed children, possibly through epigenetic alterations. Current evidence is largely based on animal and observat
Externí odkaz:
https://doaj.org/article/60e19ec22e9c433aaefb0d984ea6c7ac
Autor:
Laura S. Bleker, Jeannette Milgrom, Alexandra Sexton-Oates, Donna Parker, Tessa J. Roseboom, Alan W. Gemmill, Christopher J. Holt, Richard Saffery, Alan Connelly, Huibert Burger, Susanne R. de Rooij
Publikováno v:
Frontiers in Psychiatry, Vol 11 (2020)
Purpose of ArticleIn a previous pilot randomized controlled trial including 54 pregnant women with depression, maternal mood improved after Cognitive Behavioural Therapy (CBT) compared to treatment as usual (TAU), showing medium to large effect sizes
Externí odkaz:
https://doaj.org/article/8d66e9ffb7544443999431f369ee0153
Autor:
Alexandra Sexton‐Oates, Andrew Dodgshun, Volker Hovestadt, David T. W. Jones, David M. Ashley, Michael Sullivan, Duncan MacGregor, Richard Saffery
Publikováno v:
Molecular Oncology, Vol 12, Iss 8, Pp 1219-1232 (2018)
Childhood pilocytic astrocytomas (PA) are low‐grade tumours with an excellent prognosis. However, a minority, particularly those in surgically inaccessible locations, have poorer long‐term outcome. At present, it is unclear whether anatomical loc
Externí odkaz:
https://doaj.org/article/a3af72cfbeb645f4bd0426706ee23691
Autor:
Ashani Lecamwasam, Alexandra Sexton-Oates, Jake Carmody, Elif I Ekinci, Karen M Dwyer, Richard Saffery
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0190280 (2018)
To characterise the genomic DNA (gDNA) yield from urine and quality of derived methylation data generated from the widely used Illuminia Infinium MethylationEPIC (HM850K) platform and compare this with buffy coat samples.DNA methylation is the most w
Externí odkaz:
https://doaj.org/article/6f068e600af945f2931a0a2b86412f38
Autor:
Michaela-Kristina Keck, Martin Sill, Andrea Wittmann, Piyush Joshi, Damian Stichel, Pengbo Beck, Konstantin Okonechnikow, Philipp Sievers, Annika K. Wefers, Federico Roncaroli, Shivaram Avula, Martin G. McCabe, James T. Hayden, Pieter Wesseling, Ingrid Øra, Monica Nistér, Mariëtte E. G. Kranendonk, Bastiaan B. J. Tops, Michal Zapotocky, Josef Zamecnik, Alexandre Vasiljevic, Tanguy Fenouil, David Meyronet, Katja von Hoff, Ulrich Schüller, Hugues Loiseau, Dominique Figarella-Branger, Christof M. Kramm, Dominik Sturm, David Scheie, Tuomas Rauramaa, Jouni Pesola, Johannes Gojo, Christine Haberler, Sebastian Brandner, Tom Jacques, Alexandra Sexton Oates, Richard Saffery, Ewa Koscielniak, Suzanne J. Baker, Stephen Yip, Matija Snuderl, Nasir Ud Din, David Samuel, Kathrin Schramm, Mirjam Blattner-Johnson, Florian Selt, Jonas Ecker, Till Milde, Andreas von Deimling, Andrey Korshunov, Arie Perry, Stefan M. Pfister, Felix Sahm, David A. Solomon, David T. W. Jones
Publikováno v:
Acta Neuropathologica. 145:511-514
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6005241018e8596bb28acd018701be9
https://doi.org/10.1007/s00401-023-02538-4
https://doi.org/10.1007/s00401-023-02538-4
Autor:
Lynnette Fernandez-Cuesta, Alexandra Sexton-Oates, Leyla Bayat, Matthieu Foll, Sally C.M. Lau, Ticiana Leal
Publikováno v:
American Society of Clinical Oncology Educational Book.
Lung neuroendocrine neoplasms (NENs) encompass a spectrum of neoplasms that are subdivided into the well-differentiated neuroendocrine tumors comprising the low- and intermediate-grade typical and atypical carcinoids, respectively, and the poorly dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::817280661e931053d0e3f4ba97c4887f
https://doi.org/10.1200/edbk_390794
https://doi.org/10.1200/edbk_390794
Autor:
Lise Mangiante, Nicolas Alcala, Alexandra Sexton-Oates, Alex Di Genova, Abel Gonzalez-Perez, Azhar Khandekar, Erik N. Bergstrom, Jaehee Kim, Xiran Liu, Ricardo Blazquez-Encinas, Colin Giacobi, Nolwenn Le Stang, Sandrine Boyault, Cyrille Cuenin, Severine Tabone-Eglinger, Francesca Damiola, Catherine Voegele, Maude Ardin, Marie-Cecile Michallet, Lorraine Soudade, Tiffany M. Delhomme, Arnaud Poret, Marie Brevet, Marie-Christine Copin, Sophie Giusiano-Courcambeck, Diane Damotte, Cecile Girard, Veronique Hofman, Paul Hofman, Jérôme Mouroux, Charlotte Cohen, Stephanie Lacomme, Julien Mazieres, Vincent Thomas de Montpreville, Corinne Perrin, Gaetane Planchard, Nathalie Rousseau, Isabelle Rouquette, Christine Sagan, Arnaud Scherpereel, Francoise Thivolet, Jean-Michel Vignaud, Didier Jean, Anabelle Gilg Soit Ilg, Robert Olaso, Vincent Meyer, Anne Boland-Auge, Jean-Francois Deleuze, Janine Altmuller, Peter Nuernberg, Alejandro Ibáñez-Costa, Justo P. Castaño, Sylvie Lantuejoul, Akram Ghantous, Charles Maussion, Pierre Courtiol, Hector Hernandez-Vargas, Christophe Caux, Nicolas Girard, Nuria Lopez-Bigas, Ludmil B. Alexandrov, Françoise Galateau-Salle, Matthieu Foll, Lynnette Fernandez-Cuesta
Publikováno v:
Nature Genetics
Nature Genetics, 2023, 55 (4), pp.607-618. ⟨10.1038/s41588-023-01321-1⟩
Nature Genetics, 2023, 55 (4), pp.607-618. ⟨10.1038/s41588-023-01321-1⟩
Malignant pleural mesothelioma (MPM) is an aggressive cancer with rising incidence and challenging clinical management. Through a large series of whole-genome sequencing data, integrated with transcriptomic and epigenomic data using multiomics factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34bf4a959d167d30c59abf20d776d9d7
https://www.hal.inserm.fr/inserm-04062865
https://www.hal.inserm.fr/inserm-04062865
Publikováno v:
Nature Food. 3:804-806
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af1538daa543f8e1e17a74d242a70b13
https://doi.org/10.1038/s43016-022-00619-3
https://doi.org/10.1038/s43016-022-00619-3