Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling

Autor: Alexandra Segref, Kavya L. Vakkayil, Tsimafei Padvitski, Qiaochu Li, Virginia Kroef, Jakob Lormann, Lioba Körner, Fabian Finger, Thorsten Hoppe

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Sensation of environmental changes is vital for organismal homeostasis. Here, the authors report that protein degradation in the gut of Caenorhabditis elegans is regulated through insulin and calcineurin signalling upon neuronal sensation of temperat

Externí odkaz: https://doaj.org/article/75c498c48d244ea68168a9894b7b2c8e

A Screenable in vivo Assay to Study Proteostasis Networks in Caenorhabditis elegans

Autor: Thorsten Hoppe, Alexandra Segref, Serena Torres

Publikováno v: Genetics. 187:1235-1240

In eukaryotic cells, the ubiquitin/proteasome system (UPS) is a key determinant of proteostasis as it regulates the turnover of damaged proteins. However, it is still unclear how the UPS integrates intrinsic and environmental challenges to promote or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcf58d94f4ba774fcddf3ad3c35686bf
https://doi.org/10.1534/genetics.111.126797

Fate Specification and Tissue-specific Cell Cycle Control of the Caenorhabditis elegans Intestine

Autor: Iain L. Johnstone, Caroline Clucas, Alexandra Segref, Ralf Schnabel, Juan Cabello

Publikováno v: Molecular Biology of the Cell

The Caenorhabditis elegans β-TrCP orthologue LIN-23 of maternal origin regulates a progressive decline of CDC-25.1 abundance over several embryonic cell-cycles and specifies cell number of one tissue, the embryonic intestine.
Coordination betwe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5165f438a077a5646c5511fec132e6
https://doi.org/10.1091/mbc.e09-04-0268

Reversible 26S proteasome disassembly upon mitochondrial stress

Autor: Thorsten Hoppe, Michael H. Glickman, Oded Kleifeld, Zoi Erpapazoglou, Daria Krutauz, Nurit Livnat-Levanon, Mickael M. Cohen, Alexandra Segref, Éva Kevei, Noa Reis, Teresa Rinaldi

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2014, 7 (5), pp.1371-1380. ⟨10.1016/j.celrep.2014.04.030⟩
Cell Reports, 2014, 7 (5), pp.1371-1380. ⟨10.1016/j.celrep.2014.04.030⟩
Cell Reports, Vol 7, Iss 5, Pp 1371-1380 (2014)

International audience; In eukaryotic cells, proteasomes exist primarily as 26S holoenzymes, the most efficient configuration for ubiquitinated protein degradation. Here, we show that acute oxidative stress caused by environmental insults or mitochon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f74a9524949ad29eaa1b6455a9dceea
https://pubmed.ncbi.nlm.nih.gov/24857655

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

Autor: Steffen Priebe, Andreas Pfeiffer, Stefan Schuster, Sebastian Schmeisser, Sandra Weimer, Reinhard Guthke, Doreen Kuhlow, Matthias Platzer, Marco Groth, Michael Ristow, Alexandra Segref, Nathan L. Price, Kim Zarse, Yariv Kanfi, Marc Birringer, Kathrin Schmeisser, Haim Y. Cohen, Johannes Mansfeld, David A. Sinclair, Ines Heiland, Thorsten Hoppe

Publikováno v: Nature chemical biology. 9(11)

Sirtuins, a family of histone deacetylases, have a fiercely debated role in regulating lifespan. In contrast with recent observations, here we find that overexpression of sir-2.1, the ortholog of mammalian SirT1, does extend Caenorhabditis elegans li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5981a604228d39204f7d896f19113829
https://pubmed.ncbi.nlm.nih.gov/24141218