Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Alexandra S. Weinheimer"'
Autor:
Julie Rageul, Jennifer J. Park, Ping Ping Zeng, Eun-A Lee, Jihyeon Yang, Sunyoung Hwang, Natalie Lo, Alexandra S. Weinheimer, Orlando D. Schärer, Jung-Eun Yeo, Hyungjin Kim
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The fork protection complex (FPC), including the proteins TIMELESS and TIPIN, stabilizes the replisome to ensure unperturbed fork progression during DNA replication. Here the authors reveal that that SDE2, a PCNA-associated protein, plays an importan
Externí odkaz:
https://doaj.org/article/cf4354514492419cabdbc66606aed2dc
Autor:
Alexandra S. Weinheimer, YiTing Paung, Julie Rageul, Arafat Khan, Brian Ho, Michael Tong, Sébastien Alphonse, Markus A. Seeliger, Hyungjin Kim
Elevated DNA replication stress causes instability of the DNA replication fork and DNA mutations, which underlies tumorigenesis. The DNA replication stress regulator SDE2 binds to TIMELESS (TIM) of the fork protection complex (FPC) and enhances its s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb8b6fafea03ea3779c79e25ca081a6c
https://doi.org/10.1101/2022.05.09.490802
https://doi.org/10.1101/2022.05.09.490802
Autor:
Alexandra S. Weinheimer, YiTing Paung, Julie Rageul, Arafat Khan, Natalie Lo, Brian Ho, Michael Tong, Sébastien Alphonse, Markus A. Seeliger, Hyungjin Kim
Publikováno v:
The Journal of biological chemistry. 298(8)
Elevated DNA replication stress causes instability of the DNA replication fork and increased DNA mutations, which underlies tumorigenesis. The DNA replication stress regulator silencing-defective 2 (SDE2) is known to bind to TIMELESS (TIM), a protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f2ac9db9d5e6a83d3098faa1ac97c53
https://pubmed.ncbi.nlm.nih.gov/35850305
https://pubmed.ncbi.nlm.nih.gov/35850305
Autor:
Ukhyun Jo, Hyungjin Kim, Alexandra S. Weinheimer, Jennifer J. Park, Tri T. M. Vu, Julie Rageul
Publikováno v:
Nucleic Acids Research
Multiple pathways counteract DNA replication stress to prevent genomic instability and tumorigenesis. The recently identified human SDE2 is a genome surveillance protein regulated by PCNA, a DNA clamp and processivity factor at replication forks. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::954029c4bf6333c8a6b9915dc0662483
https://doi.org/10.1093/nar/gkz054
https://doi.org/10.1093/nar/gkz054
Autor:
Ping Ping Zeng, Jung-Eun Yeo, Hyungjin Kim, Sunyoung Hwang, Jennifer J. Park, Julie Rageul, Alexandra S. Weinheimer, Jihyeon Yang, Natalie Lo, Orlando D. Schärer, Eun-A Lee
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Protecting replication fork integrity during DNA replication is essential for maintaining genome stability. Here, we report that SDE2, a PCNA-associated protein, plays a key role in maintaining active replication and counteracting replication stress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fef72c77bc17e62b021fc20814a472a
http://europepmc.org/articles/PMC7603486
http://europepmc.org/articles/PMC7603486
Publikováno v:
DNA Repair (Amst)
Faithful duplication of the genome is critical for the survival of an organism and prevention of malignant transformation. Accurate replication of a large amount of genetic information in a timely manner is one of the most challenging cellular proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43d561b6b00b7b43db5e1c72a412c99
https://pubmed.ncbi.nlm.nih.gov/31324531
https://pubmed.ncbi.nlm.nih.gov/31324531
Publikováno v:
Biochemistry. 56(35)
The suppressor of T-cell signaling (Sts) proteins, Sts-1 and Sts-2, are homologous phosphatases that negatively regulate signaling pathways downstream of the T-cell receptor. Functional inactivation of Sts-1 and Sts-2 in a murine model leads to resis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd544162f4148bd5a53d8480566c402d
https://pubmed.ncbi.nlm.nih.gov/28759203
https://pubmed.ncbi.nlm.nih.gov/28759203
Autor:
Rageul, Julie, Park, Jennifer J, Jo, Ukhyun, Weinheimer, Alexandra S, Vu, Tri T M, Kim, Hyungjin
Publikováno v:
Nucleic Acids Research; 5/7/2019, Vol. 47 Issue 8, p3996-4010, 15p