Design and Synthesis of New Agents for Prostate Cancer Treatment Inspired by Steroidal CYP17 A1 Inhibitors

Autor: Vladimir A. Zolottsev, Alexandra S. Latysheva, Irina I. Khan, Vadim S. Pokrovsky, Alexander Y. Misharin

Publikováno v: ChemistrySelect. 7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4941b4dd7481a34fd83f6906403fe3c9
https://doi.org/10.1002/slct.202203393

Alsevirone-NF Reduces Serum Testosterone and Inhibits Prostate Cancer Xenograft Growth in Balb/c Nude Mice

Autor: Galina B. Smirnova, Yulia A. Borisova, R.L.M. Almanza, Vasiliy A. Kudinov, Alexandra S. Latysheva, K. K. Baskaev, Olga Yu Alekseeva, Natalia Yu. Anisimova, Olga M. Ipatova, Vladimir A. Zolottsev, Vadim S. Pokrovsky

Publikováno v: Clinical Cancer Drugs. 7:113-118

Background: The goal of this study was to evaluate the anticancer and testosteroneinhibitory effects of 2‘-[(E) androst-5-en-17-ylidene]methyl-4‘,5‘-dihydro-1‘,3‘-oxazole-3β-oleate (Alsevirone-NF). Materials and Methods: PC-3, DU-145, LnCa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4afe327af9c68b49fe2e20dbfe4662e8
https://doi.org/10.2174/2212697x07999200511082225

Synthesis of nitrogen-containing derivatives of 17(20)-pregnenoic, 17β-hydroxypregnanoic, and 17α-hydroxypregnanoic acids as new potential antiandrogens

Autor: Maria G. Zavialova, Vladimir P. Timofeev, Maria O. Taratynova, Ya. V. Tkachev, A. Yu. Misharin, Roman A. Novikov, Vladimir A. Zolottsev, Alexandra S. Latysheva, Vladimir A. Kostin, Olga V. Zazulina

Publikováno v: Russian Chemical Bulletin. 67:667-681

A general scheme for the synthesis of oxazoline and benzoxazole derivatives of [17(20)E]-21-norpregnene differing in the structure of the steroid moiety as well as amides of 17β-hydroxy-3-oxopregn-4-en-21-oic and 17α-hydroxy-3-oxopregn-4-en-21-oic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35fa1f636b2b3ac69e47b8f3eca687fa
https://doi.org/10.1007/s11172-018-2121-8

Steroidal Inhibitors of CYP17A1 – the Template for Novel Anti-Cancer Agents Development

Autor: Alexandra S. Latysheva, A. Yu. Misharin

Publikováno v: Biomedical Chemistry: Research and Methods; Vol. 1 No. 2 (2018); e00020
Biomedical Chemistry: Research and Methods; Том 1 № 2 (2018); e00020
Biomedical Chemistry: Research and Methods

This review deals with studies of researches of novel CYP17A1 steroidal inhibitors and relative compounds published over the last ten years. The review contains six chapters in which novel targets of well-known CYP17A1 inhibirors (abiraterone and gal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d7463deed20d4ec015b0e4020613d0
http://www.bmc-rm.org/index.php/bmcrm/article/view/20

Comparison of [17(20)E]-21-Norpregnene oxazolinyl and benzoxazolyl derivatives as inhibitors of CYP17A1 activity and prostate carcinoma cells growth

Autor: Alexander Yu. Misharin, Yaroslav V. Tkachev, Alexey V. Kuzikov, Victoria V. Shumyantseva, Vladimir A. Zolottsev, Vladimir P. Timofeev, Galina E. Morozevich, Vladimir A. Kostin, Alexandra S. Latysheva, Roman A. Novikov

Publikováno v: Steroids. 129

Four new 4,5-dihydro-1,3-oxazole, and four new benzo-[d]-oxazole derivatives of [17(20)E]-21-norpregnene, differing in the structure of steroid moiety, were synthesized and evaluated for their potency to inhibit 17α-hydroxylase/17,20-lyase (CYP17A1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf98a568e3e3b8c62533b5191204b7ec
https://pubmed.ncbi.nlm.nih.gov/29880207