Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alexandra Raulf"'
Autor:
Anne Maria Wiencierz, Manuel Kernbach, Josephine Ecklebe, Gustavo Monnerat, Stefan Tomiuk, Alexandra Raulf, Peter Christalla, Daniela Malan, Michael Hesse, Andreas Bosio, Bernd K Fleischmann, Dominik Eckardt
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143538 (2015)
Central questions such as cardiomyocyte subtype emergence during cardiogenesis or the availability of cardiomyocyte subtypes for cell replacement therapy require selective identification and purification of atrial and ventricular cardiomyocytes. Howe
Externí odkaz:
https://doaj.org/article/2ff491f8ac954558b0616920c6fb450d
Autor:
Götz Pilarczyk, Alexandra Raulf, Manuel Gunkel, Bernd K. Fleischmann, Robert Lemor, Michael Hausmann
Publikováno v:
Journal of Functional Biomaterials, Vol 7, Iss 1, p 1 (2016)
The present work addresses the question of to what extent a geometrical support acts as a physiological determining template in the setup of artificial cardiac tissue. Surface patterns with alternating concave to convex transitions of cell size dimen
Externí odkaz:
https://doaj.org/article/5e7d5ea952d546d1b75eca7cc16343fd
Autor:
Alexandra Raulf, Sebastian Preissl, Bernd K. Fleischmann, Lutz Hein, Ralf Gilsbach, Rolf Backofen, Claudia Köbele, Martin Schwaderer, Björn Grüning, Michael Hesse
Publikováno v:
Circulation Research. 117:413-423
Rationale: Epigenetic mechanisms are crucial for cell identity and transcriptional control. The heart consists of different cell types, including cardiac myocytes, endothelial cells, fibroblasts, and others. Therefore, cell type–specific analysis i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afdfbc26668cbec8502d868d0be5e414
https://doi.org/10.1161/circresaha.115.306337
https://doi.org/10.1161/circresaha.115.306337
Cardiomyocytes are prone to variations of the cell cycle, such as endoreduplication (continuing rounds of DNA synthesis without karyokinesis and cytokinesis) and acytokinetic mitosis (karyokinesis but no cytokinesis). Such atypical cell cycle variati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::484ee2059b26c8d96212b7e44808deea
https://europepmc.org/articles/PMC5409286/
https://europepmc.org/articles/PMC5409286/
Autor:
Ivar Von Kügelgen, Christa E. Müller, Geun Yung Ko, Petra Hillmann, Andreas Spinrath, Robert A. Nicholas, Hans Dieter Höltje, Evi Kostenis, Samuel C. Wolff, Alexandra Raulf
Publikováno v:
Journal of Medicinal Chemistry. 52:2762-2775
The P2Y(2) receptor, which is activated by UTP, ATP, and dinucleotides, was studied as a prototypical nucleotide-activated GPCR. A combination of receptor mutagenesis, determination of its effects on potency and efficacy of agonists and antagonists,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef68d563738ce818c87e88d630d2dc20
https://doi.org/10.1021/jm801442p
https://doi.org/10.1021/jm801442p
Autor:
Alexandra Raulf, Hannes Horder, Caroline Geisen, Sabine Grünberg, Patricia Freitag, Bernd K Fleischmann, Michael Hesse
Publikováno v:
Circulation Research. 115
The typical remodelling process after cardiac injury is scarring and compensatory hypertrophy. The limited regeneration potential of the adult heart is due to the post-mitotic status of cardiomyocytes (CMs), which are mostly binucleated. Nevertheless
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffd7f6314fb40ce45eeb153503696355
https://doi.org/10.1161/res.115.suppl_1.133
https://doi.org/10.1161/res.115.suppl_1.133
Autor:
Bernd K. Fleischmann, Daniela Malan, Andreas Bosio, Manuel Kernbach, Stefan Tomiuk, Gustavo Monnerat, Michael Hesse, Anne Maria Wiencierz, Alexandra Raulf, Peter Christalla, Josephine Ecklebe, Dominik Eckardt
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 11, p e0143538 (2015)
PLoS ONE, Vol 10, Iss 11, p e0143538 (2015)
Rationale Central questions such as cardiomyocyte subtype emergence during cardiogenesis or the availability of cardiomyocyte subtypes for cell replacement therapy require selective identification and purification of atrial and ventricular cardiomyoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507c1541ca926886c56d6b9394ff0e76
https://doi.org/10.1371/journal.pone.0143538
https://doi.org/10.1371/journal.pone.0143538
Autor:
Michael I. Kotlikoff, Hans R. Schöler, Holm Zaehres, Wilhelm Röll, Christian Steinhäuser, Michael Hesse, Alexandra M. Klein, Christian Haberlandt, Magdalena Götz, Bernd K. Fleischmann, Alexandra Raulf, Christopher J. Fügemann, Jonel Trebicka, Katrin Zimmermann, Alexander Pfeifer, Armin Welz, Gregor-Alexander Pilz, Ronald Jabs
Publikováno v:
Nature Communications; Vol 3
Nature Communications
Nature Communications
Current approaches to monitor and quantify cell division in live cells, and reliably distinguish between acytokinesis and endoreduplication, are limited and complicate determination of stem cell pool identities. Here we overcome these limitations by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44be3779c0da4944b0d1bca5af712c03
Autor:
Laura Tarnawski, Bernd K. Fleischmann, Michael Hesse, Stefan Jovinge, Alexandra Raulf, Caroline Geisen, Annika Ottersbach, Wilhelm Röll, Hannes Horder
Publikováno v:
Basic Research in Cardiology
Even though the mammalian heart has been investigated for many years, there are still uncertainties in the fields of cardiac cell biology and regeneration with regard to exact fractions of cardiomyocytes (CMs) at different developmental stages, their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff65edd2df9006b15bd3c4453a2cd99