Toxicity Profile of eBAT, a Bispecific Ligand-Targeted Toxin Directed to EGFR and uPAR, in Mice and a Clinical Dog Model

Autor: Rose H. Dicovitsky, Jill T. Schappa, Ashley J. Schulte, Haeree P. Lang, Ellen Kuerbitz, Sarah Roberts, Taylor A. DePauw, Mitzi Lewellen, Amber L. Winter, Kathy Stuebner, Michelle Buettner, Kelly Reid, Kelly Bergsrud, Sara Pracht, Andrea Chehadeh, Caitlin Feiock, M. Gerard O’Sullivan, Tim Carlson, Alexandra R. Armstrong, Danielle Meritet, Michael S. Henson, Brenda J. Weigel, Jaime F. Modiano, Antonella Borgatti, Daniel A. Vallera

Publikováno v: Toxins, Vol 16, Iss 9, p 376 (2024)

EGFR-targeted therapies are efficacious, but toxicity is common and can be severe. Urokinase type plasminogen activator receptor (uPAR)-targeted drugs are only emerging, so neither their efficacy nor toxicity is fully established. Recombinant eBAT wa

Externí odkaz: https://doaj.org/article/6505ce6cd7b5471f92672f457ebc37f6

The effect of vitamin K insufficiency on histological and structural properties of knee joints in aging mice

Autor: M. Kyla Shea, Sarah L. Booth, Stephanie G. Harshman, Donald Smith, Cathy S. Carlson, Lindsey Harper, Alexandra R. Armstrong, Min Fang, M. Leonor Cancela, Márcio Simão, Richard F. Loeser

Publikováno v: Osteoarthritis and Cartilage Open, Vol 2, Iss 3, Pp 100078- (2020)

Summary: Objective: While a role for vitamin K in maintaining joint tissue homeostasis has been proposed based on the presence of vitamin K dependent proteins in cartilage and bone, it is not clear if low vitamin K intake is causally linked to joint

Externí odkaz: https://doaj.org/article/d10933dfac2842a89f31ef84237a99cd

Overexpression of Peroxiredoxin 3 in Cartilage Reduces the Severity of Age‐Related Osteoarthritis But Not Surgically Induced Osteoarthritis in Mice

Autor: Richard F. Loeser, Philip R. Coryell, Alexandra R. Armstrong, John A. Collins, Priya Gopalakrishnan, Katie A. McDermott, Qitao Ran, Cathy S. Carlson

Publikováno v: ACR Open Rheumatology. 4:441-446

The study objective was to determine whether overexpression of the mitochondrial antioxidant peroxidase, peroxiredoxin 3 (Prx3), reduces the severity of osteoarthritis (OA) in mice.Age-related OA (age 18 and 24 months) and OA induced by destabilizati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498a3d46b58bf69d4517981283f295ff
https://doi.org/10.1002/acr2.11420

Deletion of JNK Enhances Senescence in Joint Tissues and Increases the Severity of Age‐Related Osteoarthritis in Mice

Autor: Kathryn L. Kelley, Alexandra R. Armstrong, Cathy S. Carlson, John A. Collins, Richard F. Loeser, Brian O. Diekman

Publikováno v: Arthritis & Rheumatology. 72:1679-1688

Objective To determine the role of JNK signaling in the development of osteoarthritis (OA) induced by joint injury or aging in mice. Methods In the joint injury model, 12-week-old wild-type control, JNK1-/- , JNK2-/- , and JNK1fl/fl JNK2-/- aggecan-C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::79357512b7654a2e24eda8dde0c77f70
https://doi.org/10.1002/art.41312

Systemic versus free antibiotic delivery in preventing acute exogenous implant related infection in a rat model

Autor: Conrado Aparicio, Ramon B. Gustilo, Mats Bue, Andrew H. Schmidt, Richard F. Kyle, Ole Halfdan Larsen, Glen Hansen, Dean T. Tsukayama, Arick Sabin, Gudrun Mirick Mueller, Joan E. Bechtold, Scott B. Marston, Alexandra R. Armstrong, Bruce R. Lindgren

Publikováno v: Marston, S, Mueller, G M, Sabin, A, Hansen, G T, Lindgren, B, Aparicio, C, Armstrong, A R, Larsen, O H, Schmidt, A, Kyle, R, Gustilo, R, Tsukayama, D, Bechtold, J & Bue, M 2022, ' Systemic versus Free Antibiotic Delivery in Preventing Acute Exogenous Implant Related Infection in a Rat Model ', Journal of Orthopaedic Research, vol. 40, no. 2, pp. 429-438 . https://doi.org/10.1002/jor.25052

We studied systemic ceftriaxone, and free/local tobramycin and doxycycline in a controlled rat model representing a generic acute exogenous joint infection. We hypothesized that evidence of infection (quantitative colony forming units [CFU], qualitat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1c77ead22978bc055c741cda41b1798
https://pubmed.ncbi.nlm.nih.gov/33913540