Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Alexandra R, Lucas"'
Autor:
Liqiang Zhang, Yize Henry Li, Karen Kibler, Simona Kraberger, Arvind Varsani, Julie Turk, Nora Elmadbouly, Emily Aliskevich, Laurel Spaccarelli, Bereket Estifanos, Junior Enow, Isabela Rivabem Zanetti, Nicholas Saldevar, Efrem Lim, Jessika Schlievert, Kyle Browder, Anjali Wilson, Fernando Arcos Juan, Aubrey Pinteric, Aman Garg, Henna Monder, Rohan Saju, Savanah Gisriel, Bertram Jacobs, Timothy L Karr, Esther Borges Florsheim, Vivek Kumar, John Wallen, Masmudur Rahman, Grant McFadden, Brenda G Hogue, Alexandra R Lucas
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 9, Pp 1-19 (2023)
Abstract SARS‐CoV‐2 acute respiratory distress syndrome (ARDS) induces uncontrolled lung inflammation and coagulopathy with high mortality. Anti‐viral drugs and monoclonal antibodies reduce early COVID‐19 severity, but treatments for late‐s
Externí odkaz:
https://doaj.org/article/173774a4d3874632894de3a50c2ec7e5
Autor:
Marie‐Christine Bouton, Margarethe Geiger, William P Sheffield, James A Irving, David A Lomas, Sihong Song, Ritvik S Satyanarayanan, Liqiang Zhang, Grant McFadden, Alexandra R Lucas
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 6, Pp 1-5 (2023)
Abstract In the practice of medicine, many fundamental biological pathways that require tight on/off control, such as inflammation and circulatory homeostasis, are regulated by serine proteinases, but we rarely consider the unique protease inhibitors
Externí odkaz:
https://doaj.org/article/9884bec85769492f83aef84706a3bcf0
Autor:
Mostafa Hamada, Kyle Steven Varkoly, Omer Riyadh, Roxana Beladi, Ganesh Munuswamy-Ramanujam, Alan Rawls, Jeanne Wilson-Rawls, Hao Chen, Grant McFadden, Alexandra R. Lucas
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1167 (2024)
The urokinase-type plasminogen activator receptor (uPAR) is a unique protease binding receptor, now recognized as a key regulator of inflammation. Initially, uPA/uPAR was considered thrombolytic (clot-dissolving); however, recent studies have demonst
Externí odkaz:
https://doaj.org/article/4d7e62f3f3fc45fc8b1b9bc45bfb17e0
Autor:
Kyle Varkoly, Roxana Beladi, Mostafa Hamada, Grant McFadden, James Irving, Alexandra R. Lucas
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1393 (2023)
Serine protease inhibitors, SERPINS, are a highly conserved family of proteins that regulate serine proteases in the central coagulation and immune pathways, representing 2–10% of circulating proteins in the blood. Serine proteases form cascades of
Externí odkaz:
https://doaj.org/article/adea72af847940309edb1e7f02d8ebea
RNA Virus Gene Signatures Detected in Patients With Cardiomyopathy After Chemotherapy; A Pilot Study
Autor:
Kyle Varkoly, Shaoyuan Tan, Roxana Beladi, David Fonseca, Isabela Rivabem Zanetti, Simona Kraberger, Chintan Shah, Jordan R. Yaron, Liqiang Zhang, Michael Juby, Ayman Fath, Sriram Ambadapadi, Melanie House, Paul Maranian, Carl J. Pepine, Arvind Varsani, Jan Moreb, Stacey Schultz-Cherry, Alexandra R. Lucas
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
BackgroundViral infections are pervasive and leading causes of myocarditis. Immune-suppression after chemotherapy increases opportunistic infections, but the incidence of virus-induced myocarditis is unknown.ObjectiveAn unbiased, blinded screening fo
Externí odkaz:
https://doaj.org/article/286ff97e896540d9825a6b8182791a9a
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2022)
Externí odkaz:
https://doaj.org/article/70030d67d35b41538c29b1070046a79c
Autor:
Brent Ju, Owen Guo, Dathe Z. Benissan-Messan, McKinley H. Shawver, Peng Chen, Bingchuan Geng, Siqi Wei, Jordan R. Yaron, Alexandra R. Lucas, Hua Zhu
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Purpose: Chemical corneal injuries carry a high morbidity and commonly lead to visual impairment. Here, we investigate the role of Serp-1, a serine protease inhibitor, in corneal wound healing.Methods: An alkaline-induced corneal injury was induced i
Externí odkaz:
https://doaj.org/article/2a4c4e5e6d3341e9a7991eb8786abc95
Autor:
Jordan R. Yaron, Hao Chen, Sriram Ambadapadi, Liqiang Zhang, Amanda M. Tafoya, Barbara H. Munk, Dara N. Wakefield, Jorge Fuentes, Bruno J. Marques, Krishna Harripersaud, Mee Yong Bartee, Jennifer A. Davids, Donghang Zheng, Kenneth Rand, Lisa Dixon, Richard W. Moyer, William L. Clapp, Alexandra R. Lucas
Publikováno v:
Journal of Inflammation, Vol 16, Iss 1, Pp 1-9 (2019)
Abstract Background Ischemia-reperfusion injury (IRI) is an antigen-independent, innate immune response to arterial occlusion and ischemia with subsequent paradoxical exacerbation after reperfusion. IRI remains a critical problem after vessel occlusi
Externí odkaz:
https://doaj.org/article/2a583ac6ff0c40f1beb5e17e5a621f77
Autor:
Jacek M. Kwiecien, Wojciech Dabrowski, Barbara Marzec-Kotarska, Christian J. Kwiecien-Delaney, Jordan R. Yaron, Liqiang Zhang, Lauren Schutz, Alexandra R. Lucas
Publikováno v:
Folia Neuropathologica, Vol 57, Iss 1, Pp 41-50 (2019)
Spinal cord injury (SCI)-initiated inflammation was treated with anti-inflammatory reagents. We compared local spinal cord or intraperitoneal infusion of two Myxoma virus derived immune modulating proteins, Serp-1 and M-T7, with dexamethasone (DEX).
Externí odkaz:
https://doaj.org/article/d3fc00cdebe54fd1a23693816153ca8a
Autor:
Ayman R. Fath MD, Amro Aglan MBChB, Kyle S. Varkoly BS, Abdullah S. Eldaly MBChB, Roxana N. Beladi BA, Arnold Forlemu MD, Nawfal Mihyawi MD, Anup Solsi MD, Sharjeel Israr MD, Alexandra R. Lucas MD, FRCP
Publikováno v:
Journal of Investigative Medicine High Impact Case Reports, Vol 9 (2021)
In this article, we report a case of a 61-year-old male who was diagnosed with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), presenting with acute respiratory distress syndrome requiring intubation and hemodynamic support, marked D-Di
Externí odkaz:
https://doaj.org/article/6c62c426e1634b9d9bdeae590cde8c9d