Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Alexandra R, Grassian"'
Autor:
Scott A. Ribich, Heike Keilhack, Jesse J. Smith, Richard Chesworth, Robert A. Copeland, Peter Ho, John Campbell, Maria Roche, Kristy Kuplast-Barr, Sarah K. Knutson, Igor Feldman, Alexandra R. Grassian, Allison Drew, Kelli Armstrong, Elayne Chan-Penebre
The SWI/SNF complex is a major regulator of gene expression and is increasingly thought to play an important role in human cancer, as evidenced by the high frequency of subunit mutations across virtually all cancer types. We previously reported that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32f0193e841ebe292cdd7fd3a4087a01
https://doi.org/10.1158/1535-7163.c.6537771.v1
https://doi.org/10.1158/1535-7163.c.6537771.v1
Autor:
Scott A. Ribich, Heike Keilhack, Jesse J. Smith, Richard Chesworth, Robert A. Copeland, Peter Ho, John Campbell, Maria Roche, Kristy Kuplast-Barr, Sarah K. Knutson, Igor Feldman, Alexandra R. Grassian, Allison Drew, Kelli Armstrong, Elayne Chan-Penebre
PDF File -1 MB, Supplemental data is to further support the statements made it the main text. Captions: Supplemental Table 1: Cell Lines used in the CRISPR pooled screen. Supplemental Table 2: Table of ovarian lines screened for tazemetostat sensitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28078359a52e1425c550d2baf2f9465b
https://doi.org/10.1158/1535-7163.22504545
https://doi.org/10.1158/1535-7163.22504545
Autor:
Christian M. Metallo, Raymond Pagliarini, Anne N. Murphy, Matthew G. Vander Heiden, Joseph D. Growney, Christopher Straub, Erika D. Handly, Hong Yin, Franklin Chung, Carol Joud-Caldwell, Chad Vickers, Fallon Lin, Minying Pu, Kelly L. Slocum, Xiamei Zhang, Courtney R. Green, Ajit S. Divakaruni, Shawn M. Davidson, Seth J. Parker, Alexandra R. Grassian
PDF file - 348KB, Figure S1: Isogenic IDH1 mutation compromises metabolic reprogramming under hypoxia. Figure S2: Simulated and measured uncorrected MIDs. Figure S3: Compromised Reductive TCA Metabolism is specific to cells with mutant IDH1. Figure S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376c269450e5947866e21be024083aa0
https://doi.org/10.1158/0008-5472.22404444
https://doi.org/10.1158/0008-5472.22404444
Autor:
Christian M. Metallo, Raymond Pagliarini, Anne N. Murphy, Matthew G. Vander Heiden, Joseph D. Growney, Christopher Straub, Erika D. Handly, Hong Yin, Franklin Chung, Carol Joud-Caldwell, Chad Vickers, Fallon Lin, Minying Pu, Kelly L. Slocum, Xiamei Zhang, Courtney R. Green, Ajit S. Divakaruni, Shawn M. Davidson, Seth J. Parker, Alexandra R. Grassian
PDF file - 93KB, Estimates Fluxes for HCT116 Parental and IDH1 R132H/+ 2H1 cells under Normoxia and Hypoxia (2 percent Oxygen).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b28b49cb8efffcec5890dedaa06d63
https://doi.org/10.1158/0008-5472.22404438
https://doi.org/10.1158/0008-5472.22404438
Autor:
Christian M. Metallo, Raymond Pagliarini, Anne N. Murphy, Matthew G. Vander Heiden, Joseph D. Growney, Christopher Straub, Erika D. Handly, Hong Yin, Franklin Chung, Carol Joud-Caldwell, Chad Vickers, Fallon Lin, Minying Pu, Kelly L. Slocum, Xiamei Zhang, Courtney R. Green, Ajit S. Divakaruni, Shawn M. Davidson, Seth J. Parker, Alexandra R. Grassian
PDF file - 136KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c83526185c0fd14582306beb658d0d3
https://doi.org/10.1158/0008-5472.22404441.v1
https://doi.org/10.1158/0008-5472.22404441.v1
Autor:
Christian M. Metallo, Raymond Pagliarini, Anne N. Murphy, Matthew G. Vander Heiden, Joseph D. Growney, Christopher Straub, Erika D. Handly, Hong Yin, Franklin Chung, Carol Joud-Caldwell, Chad Vickers, Fallon Lin, Minying Pu, Kelly L. Slocum, Xiamei Zhang, Courtney R. Green, Ajit S. Divakaruni, Shawn M. Davidson, Seth J. Parker, Alexandra R. Grassian
Oncogenic mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in several types of cancer, but the metabolic consequences of these genetic changes are not fully understood. In this study, we performed 13C metabolic flux analysis on a panel of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e49274eaaaa28fa6411ec05c17088e
https://doi.org/10.1158/0008-5472.c.6506604.v1
https://doi.org/10.1158/0008-5472.c.6506604.v1
Autor:
Michael J Thomenius, Jennifer Totman, Darren Harvey, Lorna H Mitchell, Thomas V Riera, Kat Cosmopoulos, Alexandra R Grassian, Christine Klaus, Megan Foley, Elizabeth A Admirand, Haris Jahic, Christina Majer, Tim Wigle, Suzanne L Jacques, Jodi Gureasko, Dorothy Brach, Trupti Lingaraj, Kip West, Sherri Smith, Nathalie Rioux, Nigel J Waters, Cuyue Tang, Alejandra Raimondi, Michael Munchhof, James E Mills, Scott Ribich, Margaret Porter Scott, Kevin W Kuntz, William P Janzen, Mikel Moyer, Jesse J Smith, Richard Chesworth, Robert A Copeland, P Ann Boriack-Sjodin
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0197372 (2018)
A key challenge in the development of precision medicine is defining the phenotypic consequences of pharmacological modulation of specific target macromolecules. To address this issue, a variety of genetic, molecular and chemical tools can be used. A
Externí odkaz:
https://doaj.org/article/8d24a066e3c44272bf8a8c8842bb3428
Autor:
Satoshi Kawano, Alexandra R Grassian, Masumi Tsuda, Sarah K Knutson, Natalie M Warholic, Galina Kuznetsov, Shanqin Xu, Yonghong Xiao, Roy M Pollock, Jesse J Smith, Kevin W Kuntz, Scott Ribich, Yukinori Minoshima, Junji Matsui, Robert A Copeland, Shinya Tanaka, Heike Keilhack
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170539 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0158888.].
Externí odkaz:
https://doaj.org/article/794b53db2605483789c901bbe947d23f
Autor:
Satoshi Kawano, Alexandra R Grassian, Masumi Tsuda, Sarah K Knutson, Natalie M Warholic, Galina Kuznetsov, Shanqin Xu, Yonghong Xiao, Roy M Pollock, Jesse S Smith, Kevin K Kuntz, Scott Ribich, Yukinori Minoshima, Junji Matsui, Robert A Copeland, Shinya Tanaka, Heike Keilhack
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158888 (2016)
The catalytic activities of covalent and ATP-dependent chromatin remodeling are central to regulating the conformational state of chromatin and the resultant transcriptional output. The enzymes that catalyze these activities are often contained withi
Externí odkaz:
https://doaj.org/article/056beb7617a242fcb7ff5a42aa85f783
Autor:
Alexandra R. Grassian, Joseph Kim, Omar Ahmad, Kevin Barvian, Alison Davis, Tom Dineen, Wei Hu, Ebby Job, Ludivine Moine, Kate Newberry, Maria Roche, Doug Shorten, Yeon Sook Choi, Francis Wolenski, Sebastian Bauer, Cesar Serrano, Jonathan Trent, Suzanne George
Publikováno v:
Cancer Research. 82:LB565-LB565
Gastrointestinal stromal tumor (GIST) is the most common type of sarcoma, with approximately 5,000 patients diagnosed per year in the US. Approximately 80% of patients with GIST present with mutations in the c-KIT oncogene at exon 9 or 11, which lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab4d265fca2a9a3d94fcb15e6f55c1a6
https://doi.org/10.1158/1538-7445.am2022-lb565
https://doi.org/10.1158/1538-7445.am2022-lb565